Results 91 to 100 of about 15,825 (230)

A hope for ineffective antibiotics to return to treatment: investigating the anti-biofilm potential of melittin alone and in combination with penicillin and oxacillin against multidrug resistant-MRSA and -VRSA

Frontiers in Microbiology
BackgroundThe emergence and rapid spread of multi-drug resistant (MDR) bacterial strains, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant S.
Saba Jalalifar, Saba Jalalifar, Shabnam Razavi, Shabnam Razavi, Rasoul Mirzaei, Gholamreza Irajian, Gholamreza Irajian, Kamran Pooshang Bagheri   +7 more
doaj   +1 more source

AP-UV-MALDI mit flüssigen Matrizes: stabile Ionenausbeuten von mehrfach geladenen Peptid- und Proteinionen für die empfindliche Massenspektrometrie [PDF]

, 2013
In der biologischen Massenspektrometrie (MS) werden überwiegend zwei Ionisationstechniken für die Analyse von grçßeren Biomolekfürlen wie Polypeptiden eingesetzt.
Cramer, Cramer, Cramer, Drancourt, Glish, Inutan, Karas, Karas, Konermann, Kononikhin, König, Körner, Loo, Palmblad, Rohlfing, Schneider, Seeley, Sterling, Sterling, Towers, Trimpin, Wiesner, Wilm   +22 more
core   +1 more source

Payload‐Driven Design of Polymeric Carriers for Nucleic Acid Delivery: Insights from Structure–Function Relationships

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Polymeric carriers provide versatile platforms for nucleic acid delivery. This review introduces a novel perspective inspired by protein structural organization to explore structure–function relationships of polymeric carriers, highlighting requirements of different nucleic acid payloads.
Hanieh Moradian, Charlotte Maeve Dunne, Manfred Gossen, Matthias Hartlieb   +3 more
wiley   +1 more source

The membrane effects of melittin on gastric and colorectal cancer.

PLoS ONE, 2019
The cytotoxic effects of melittin, a bee-venom peptide, have been widely studied towards cancer cells. Typically, these studies have examined the effect of melittin over extended-time courses (6-24 hours), meaning that immediate cellular interactions ...
Caroline Soliman, Sarah Eastwood, Vi Khanh Truong, Paul A Ramsland, Aaron Elbourne   +4 more
doaj   +1 more source

Chemical characterization and bioactive properties of bee venom samples from Northeast of Portugal [PDF]

, 2017
O veneno de abelha (VA) ou apitoxina é um produto apícola que tem sido utilizado desde os tempos ancestrais para múltiplas finalidades, nomeadamente em medicina tradicional na apiterapia.
Calhelha, Ricardo C., Falcão, Soraia, Ferreira, Isabel C.F.R., Sobral, Filipa, Vilas-Boas, Miguel   +4 more
core   +1 more source

Pore formation and translocation of melittin

Biophysical Journal, 1997
Melittin, a bee venom, is a basic amphiphilic peptide, which mainly acts on the lipid matrix of membranes, lysing various cells. To elucidate the molecular mechanism, we investigated its interactions with phospholipid vesicles. The peptide formed a pore with a short lifetime in the membrane, as revealed by the release of an anionic fluorescent dye ...
Matsuzaki, K., Yoneyama, S., Miyajima, K.   +2 more
openaire   +2 more sources

The Novel Fusion Protein Melittin‐MIL‐2 Exhibits Strong Antitumor Immune Effect in Lung Adenocarcinoma Cell A549

The Clinical Respiratory Journal
In previous studies, we developed a novel fusion protein named “melittin‐MIL‐2” which exhibited more anti‐tumor activity. However, it remains unclear whether melittin‐MIL‐2 possesses antitumor immune effect on lung adenocarcinoma.
Weize Gao, Wenshuai Li, Zhan Wang, Yongxin Li, Mingjun Liu   +4 more
doaj   +1 more source

Coupling hydrophobic, dispersion, and electrostatic contributions in continuum solvent models [PDF]

, 2005
Recent studies of the hydration of micro- and nanoscale solutes have demonstrated a strong {\it coupling} between hydrophobic, dispersion and electrostatic contributions, a fact not accounted for in current implicit solvent models.
H. S. Ashbaugh, J. A. McCammon, J. Dzubiella, J. M. J. Swanson, P. Kralchevsky   +4 more
core   +1 more source

The structure of melittin in membranes

Biophysical Journal, 1986
The conformation of the polypeptide melittin in lipid membranes as determined by Raman spectroscopy is a bent alpha-helix formed by the mainly hydrophobic residues 1-21, and a nonhelical COOH-terminal segment of the hydrophilic residues 22-26. Fluorescence quenching experiments on residue Trp19 reveal that all COOH-termini are located on that side of a
Vogel, H., Jähnig, F.
openaire   +2 more sources

Effects of Melittin Treatment in Cholangitis and Biliary Fibrosis in a Model of Xenobiotic-Induced Cholestasis in Mice

Toxins, 2015
Cholangiopathy is a chronic immune-mediated disease of the liver, which is characterized by cholangitis, ductular reaction and biliary-type hepatic fibrosis. There is no proven medical therapy that changes the course of the disease.
Kyung-Hyun Kim, Hyun-Jung Sung, Woo-Ram Lee, Hyun-Jin An, Jung-Yeon Kim, Sok Cheon Pak, Sang-Mi Han, Kwan-Kyu Park   +7 more
doaj   +1 more source