Results 71 to 80 of about 15,825 (230)

Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis [PDF]

, 2014
The NF-κB signaling pathway is implicated in various inflammatory diseases, including rheumatoid arthritis (RA); therefore, inhibition of this pathway has the potential to ameliorate an array of inflammatory diseases.
Agarwal, Antonina Akk, Christine T.N. Pham, Godl, Hua Pan, Hui-fang Zhou, Huimin Yan, J. Stacy Allen, Kirk K. Hou, Luke E. Springer, McInnes, Pan, Pan, Pham, Samuel A. Wickline, Sessa, Soenen, Soman, Szekanecz, Terato, Ying Hu   +20 more
core   +2 more sources

Exploring the Key Role of Nanotechnology on Intratumoral Microbiome Modulation for Cancer Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.
The review provides a comprehensive analysis of microbiome‐mediated oncogenic mechanisms in various cancers, emphasizing the unique therapeutic strategies facilitated by nanotechnology. It aims to fill this gap by systematically reviewing nanotechnology‐driven strategies for microbiome elimination, with a focus on their ability to improve the cold TME ...
Yumei Gan, Yan Zhang, Xia Dong, Feng Lv
wiley   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

SiO2–alginate–melittin nano-conjugates suppress the proliferation of ovarian cancer cells: a controlled release approach leveraging alginate lyase

Cancer Nanotechnology
Background Ovarian cancer treatment is challenged by resistance and off-target effects. Melittin shows promise against cancer but is limited by its instability and harmful cellular interactions. Our study introduces SiO2–alginate–melittin nano-conjugates
Lihui Si, Shuli Yang, Ruixin Lin, Shiyu Gu, Chuhan Yan, Jia Yan   +5 more
doaj   +1 more source

Liquid AP-UV-MALDI enables stable ion yields of multiply charged peptide and protein ions for sensitive analysis by mass spectrometry [PDF]

, 2013
In biological mass spectrometry (MS), two ionization techniques are predominantly employed for the analysis of larger biomolecules, such as polypeptides.
Cramer, Rainer, Dreisewerd, Klaus, Hillenkamp, Franz, Pirkl, Alexander   +3 more
core   +1 more source

Mechanism‐Driven Screening of Membrane‐Targeting and Pore‐Forming Antimicrobial Peptides

Advanced Science, Volume 13, Issue 9, 13 February 2026.
To combat antibiotic resistance, this study employs mechanism‐driven screening with machine learning to identify pore‐forming antimicrobial peptides from amphibian and human metaproteomes. Seven peptides are validated, showing minimal toxicity and membrane disruption.
Jiaxuan Li, Chenguang Yang, Ruihan Dong, Juan Francisco Bada Juarez, Lei Wang, Maximilian Emanuel Wettstein, Dali Wang, Chan Cao, Ying Lu, Chen Song   +9 more
wiley   +1 more source

Administration of Apis cerana cerana melittin gene-encapsulated pectin for breast cancer therapy: an investigation of a new anti-cancer agent

Cancer Nanotechnology
Purpose One intriguing therapy option for cancer is the peptide Melittin. This study assessed the in vitro anticancer effects of Melittin, Melittin-loaded pectin, and free pectin on mammary cell lines. Methods The “thin-layer hydration approach” produced
Esmaeil Alibeigi, Arsham Azari Dehkordi, Milad Asadian, Abbas Doosti, Tohid Piri-Gharaghie   +4 more
doaj   +1 more source

Peptide and Drug‐Protected Gold Nanoclusters as Promising Biomaterials: Synthesis, Properties, and Applications

Aggregate, Volume 7, Issue 2, February 2026.
The integration of atomically precise gold nanoclusters with peptides or drugs represents a cutting‐edge class of nanomaterials in the biomedical field, owing to their unique physicochemical properties such as water solubility, excellent biocompatibility, low toxicity, and good renal clearance.
Rebeca Garcia Moura, M. Terêsa Machini, Rongchao Jin   +2 more
wiley   +1 more source

A novel melittin nano-liposome exerted excellent anti-hepatocellular carcinoma efficacy with better biological safety

Journal of Hematology & Oncology, 2017
Melittin is the main effective component of bee venom and has extensive biological functions; however, serious side effects have restricted its clinical application.
Jie Mao, Shujun Liu, Min Ai, Zhuo Wang, Duowei Wang, Xianjing Li, Kaiyong Hu, Xinghua Gao, Yong Yang   +8 more
doaj   +1 more source

\u3cem\u3eRhizobium etli\u3c/em\u3e CE3 Bacteroid Lipopolysaccharides Are Structurally Similar but Not Identical to Those Produced by Cultured CE3 Bacteria [PDF]

, 2007
Rhizobium etli CE3 bacteroids were isolated from Phaseolus vulgaris root nodules. The lipopolysaccharide (LPS) from the bacteroids was purified and compared with the LPS from laboratory-cultured R.
Carlson, Russell W., D\u27Haeze, Wim, Freshour, Glenn, Leoff, Christine, Noel, K. Dale   +4 more
core   +1 more source