MeMAGEN: A Phase IIa/IIb open‐label trial of memantine testing safety and tolerability in sickle cell patients [PDF]
HemaSphereAdministration of memantine, an antagonist of the N‐methyl‐ d‐aspartate receptor, prevents Ca2+ overload and dehydration of red blood cells (RBCs) in patients with sickle cell disease (SCD).
Ariel Koren +7 more
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Pharmaceuticals, 2022 Glutamate is an excitatory neurotransmitter in the nervous system. Excessive glutamate transmission can lead to increased calcium ion expression, related to increased neurotoxicity.
Radoslav Chayrov +7 more
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The Highs and Lows of Memantine—An Autophagy and Mitophagy Inducing Agent That Protects Mitochondria
Cells, 2023 Memantine is an FDA-approved, non-competitive NMDA-receptor antagonist that has been shown to have mitochondrial protective effects, improve cell viability and enhance clearance of Aβ42 peptide.
Sholto de Wet +7 more
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Ibrain, 2023 Memantine is a noncompetitive moderate‐affinity strong voltage‐dependent N‐methyl‐D‐aspartate receptor antagonist. It has been used to treat Alzheimer's disease (AD) since 1989.
Bin‐Can Tang, Ya‐Ting Wang, Jie Ren
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BMC Neurology, 2022 Background Mild cognitive impairment in Parkinson’s disease (PD-MCI) is associated with an increased risk of cognitive decline. PD-MCI is characterized by impairments in executive function and visuospatial recognition.
Shoji Kawashima +2 more
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Nootropics use in the workplace. Psychiatric and ethical aftermath towards the new frontier of bioengineering [PDF]
, 2020 OBJECTIVE: The authors have sought to expound upon and shed a light on the rise of nootropics, which have gradually taken on a more and more relevant role in workplaces and academic settings.
Bersani, G +5 more
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The cytotoxic effect of memantine and its effect on cytoskeletal proteins expression in metastatic breast cancer cell line [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s):Breast cancer is an important leading cause of death from cancer. Stathmin and tau proteins are regulators of cell motility, and their overexpression is associated with the progression and bad prognosis of breast cancer.
Sima Seifabadi +5 more
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The Effect of Memantine on the Expression of Dopamine Receptors in the Striatum of Male Rats With Morphine Addiction [PDF]
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2023 Background and Objectives: Studies have indicated that the chronic use of morphine can result in physical and psychological dependence. Morphine dependence is associated with several cellular and molecular alterations in the mesocorticolimbic system, and
Sahar Khalili Samani +5 more
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Effect of memantine, an anti-Alzheimer’s drug, on rodent microglial cells in vitro
Scientific Reports, 2021 The pathophysiology of Alzheimer’s disease (AD) is related to neuroinflammatory responses mediated by microglia. Memantine, an antagonist of N-methyl-d-aspartate (NMDA) receptors used as an anti-Alzheimer’s drug, protects from neuronal death accompanied ...
Toru Murakawa-Hirachi +4 more
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Pharmacokinetic Drug-Drug Interaction and Responsible Mechanism between Memantine and Cimetidine
Pharmaceutics, 2018 A sensitive and simple chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to evaluate memantine in rat plasma. Memantine and propranolol (internal standard) in rat plasma was extracted using a methanol precipitation method.
Young A. Choi +2 more
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