Results 41 to 50 of about 419,747 (259)

A Case of Neisseria sicca Bacteremia Due to Eculizumab Therapy

Annals of Internal Medicine: Clinical Cases, 2023
Eculizumab is a monoclonal antibody indicated for the treatment of complement-mediated disorders. Despite its utility, eculizumab increases risk for infection with Neisseria species, owing to membrane attack complex inhibition.
Kelly A. Russo, Ted Louie
doaj   +1 more source

Premature Drug Release from Polyethylene Glycol (PEG)-Coated Liposomal Doxorubicin via Formation of the Membrane Attack Complex.

ACS Nano, 2020
Anti-polyethylene glycol (PEG) antibodies are present in many healthy individuals as well as in patients receiving polyethylene glycol-functionalized drugs.
Even Chen, Bing‐Mae Chen, Yu-Cheng Su, Yuan-Chih Chang, T. Cheng, Yechezekel Barenholz, S. Roffler   +6 more
semanticscholar   +1 more source

Clinical Isolates of Acinetobacter spp. Are Highly Serum Resistant Despite Efficient Recognition by the Complement System

Frontiers in Immunology, 2022
Gram-negative bacteria from the genus Acinetobacter are responsible for life-threating hospital-related infections such as pneumonia, septicemia, and meningitis, especially in immunocompromised patients.
Michal Magda, Serena Bettoni, Maisem Laabei, Derek Fairley, Thomas A. Russo, Kristian Riesbeck, Anna M. Blom   +6 more
doaj   +1 more source

Astrocyte- and Neuron-Derived Extracellular Vesicles from Alzheimer’s Disease Patients Effect Complement-Mediated Neurotoxicity

Cells, 2020
We have previously shown that blood astrocytic-origin extracellular vesicles (AEVs) from Alzheimer’s disease (AD) patients contain high complement levels.
Carlos J. Nogueras-Ortiz, Vasiliki Mahairaki, Francheska Delgado-Peraza, Debamitra Das, Konstantinos Avgerinos, Erden Eren, Matthew Hentschel, Edward J. Goetzl, Mark P. Mattson, Dimitrios Kapogiannis   +9 more
doaj   +1 more source

Complement-5 Inhibition Deters Progression of Fulminant Hepatitis to Acute Liver Failure in Murine ModelsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Acute liver failure (ALF) is a life-threatening condition with limited treatment alternatives. ALF pathogenesis seemingly involves the complement system. However, no complement-targeted intervention has been clinically applied.
Jiro Kusakabe, Koichiro Hata, Hidetaka Miyauchi, Tetsuya Tajima, Yi Wang, Ichiro Tamaki, Junya Kawasoe, Yusuke Okamura, Xiangdong Zhao, Tatsuya Okamoto, Tatsuaki Tsuruyama, Shinji Uemoto   +11 more
doaj   +1 more source

Requirements for membrane attack complex formation and anaphylatoxins binding to collagen-activated platelets. [PDF]

PLoS ONE, 2011
The activation of complement during platelet activation is incompletely understood.We sought to explore the formation of C5b-9 and anaphylatoxins binding to collagen-activated platelets.C5b-9, anaphylatoxins C3a, C4a and C5a, and anaphylatoxin receptors ...
Catherine Martel, Sylvie Cointe, Pascal Maurice, Saïd Matar, Marta Ghitescu, Pierre Théroux, Arnaud Bonnefoy   +6 more
doaj   +1 more source

Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models

Acta Neuropathologica Communications, 2022
Complement is involved in developmental synaptic pruning and pathological synapse loss in Alzheimer’s disease. It is posited that C1 binding initiates complement activation on synapses; C3 fragments then tag them for microglial phagocytosis. However, the
Sarah M. Carpanini, Megan Torvell, Ryan J. Bevan, Robert A. J. Byrne, Nikoleta Daskoulidou, Takashi Saito, Takaomi C. Saido, Philip R. Taylor, Timothy R. Hughes, Wioleta M. Zelek, B. Paul Morgan   +10 more
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Soluble MAC is primarily released from MAC-resistant bacteria that potently convert complement component C5

eLife, 2022
The membrane attack complex (MAC or C5b-9) is an important effector of the immune system to kill invading microbes. MAC formation is initiated when complement enzymes on the bacterial surface convert complement component C5 into C5b.
Dennis J Doorduijn, Marie V Lukassen, Marije FL van 't Wout, Vojtech Franc, Maartje Ruyken, Bart W Bardoel, Albert JR Heck, Suzan HM Rooijakkers   +7 more
doaj   +1 more source

Research progress of perforin 2 [PDF]

Jichu yixue yu linchuang
Perforin 2 (MPEG 1) is a member of the MACPF(membrane attack complex/PRF membrane attack complex/perforin) superfamily, which is mainly secreted by cytotoxic T lymphocytes, natural killer cells and macrophages Through the formation of active pores on the
DENG Zhiyuan, BAI Lu, YU Rong
doaj   +1 more source

Membrane attack complex inhibitor CD59a protects against focal cerebral ischemia in mice

Journal of Neuroinflammation, 2010
Background The complement system is a crucial mediator of inflammation and cell lysis after cerebral ischemia. However, there is little information about the exact contribution of the membrane attack complex (MAC) and its inhibitor-protein CD59.
Nietfeld Wilfried, Dirnagl Ulrich, Morgan B Paul, Stahel Philip F, Khojasteh Uldus, Harhausen Denise, Trendelenburg George   +6 more
doaj   +1 more source