Results 291 to 300 of about 178,051 (334)

Membrane targeting of a folded and cofactor‐containing protein

European Journal of Biochemistry, 2003
Targeting of proteins to and translocation across the membranes is a fundamental biological process in all organisms. In bacteria, the twin arginine translocation (Tat) system can transport folded proteins. Here, we demonstrate in vivo that the high potential iron‐sulfur protein (HiPIP) from Allochromatium vinosum is translocated into the periplasmic ...
Thomas, Brüser, Takahiro, Yano, Daniel C, Brune, Fevzi, Daldal   +3 more
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Membrane Cofactor Protein and Factor I: Mutations and Transplantation

Seminars in Thrombosis and Hemostasis, 2006
Mutations in the genes for three complement regulators-complement factor H (CFH), membrane cofactor protein (MCP), and factor I (IF)-have now been described in patients with atypical HUS. The functional effects of these mutations have been studied in detail and have been shown to affect secretion, expression, and regulatory function. Genotype-phenotype
Kavanagh D, Goodship THJ
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Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa

Molecular Reproduction and Development, 2000
AbstractMembrane cofactor protein (MCP; CD46) is a complement regulator widely expressed as four isoforms that arise via alternative splicing. On human spermatozoa, MCP is expressed on the inner acrosomal membrane and alterations of spermatozoa MCP may be associated with infertility.
Rebecca C, Riley, Claudia, Kemper, Marilyn, Leung, John P, Atkinson   +3 more
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Decay-Accelerating Factor and Membrane Cofactor Protein

1990
Cells exposed to plasma proteins are frequently under attack from the complement system. This can arise either as a bystander process to the classical or alternative pathways of activation initiated during the immune response to foreign particles and organisms or from the constant tick-over of the alternative pathway.
D M, Lublin, J P, Atkinson
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Human membrane cofactor protein (MCP, CD46): multiple isoforms and functions

The International Journal of Biochemistry & Cell Biology, 1999
Human membrane cofactor protein (MCP, CD46) is a 45-70 kDa protein with genetic and tissue-specific heterogeneity, and is expressed on all nucleated cells. MCP consists from N-terminus of 4 short consensus repeats (SCRs), 1-3 serine/threonine-rich (ST) domains, a transmembrane domain (TM) and a cytoplasmic tail (CYT). More than 8 isoforms are generated
T, Seya, A, Hirano, M, Matsumoto, M, Nomura, S, Ueda   +4 more
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Soluble CD46 (membrane cofactor protein, MCP) in human reproductive tract fluids

Journal of Reproductive Immunology, 1996
CD46 (membrane cofactor protein, MCP) is a cell surface complement regulatory protein which may have an additional role in human sperm-egg interaction. A soluble form (sCD46) has also been detected in a number of biological fluids, most notably seminal plasma.
P J, McLaughlin, S J, Holland, C T, Taylor, K S, Olah, D I, Lewis-Jones, T, Hara, T, Seya, P M, Johnson   +7 more
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Ontogeny of membrane cofactor protein: phenotypic divergence in the fetal heart

Lupus, 1995
Human adult cells are protected from complement-induced damage in part by membrane cofactor protein (MCP, CD46). To examine fetal characteristics which might influence autoantibody-mediated diseases acquired in utero, such as heart block in neonatal lupus, the tissue expression of MCP was studied.
A, Gorelick, T, Oglesby, W, Rashbaum, J, Atkinson, J P, Buyon   +4 more
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Identification and characterization of membrane cofactor protein of human spermatozoa.

The Journal of Immunology, 1992
Abstract Membrane cofactor protein (MCP) regulates C activation by serving as a cofactor for the cleavage of C3b and C4b by the serine protease factor I. An MCP-like molecule on the inner acrosomal membrane of human spermatozoa has been characterized. Three mAb and a rabbit polyclonal antibody against MCP recognized the sperm protein. On
F, Cervoni, T J, Oglesby, E M, Adams, C, Milesifluet, M, Nickells, P, Fenichel, J P, Atkinson, B L, Hsi   +7 more
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Human astrocytes express membrane cofactor protein (CD46), a regulator of complement activation

Journal of Neuroimmunology, 1992
Expression of membrane cofactor protein (CD46) on cultured human astrocytes was demonstrated by indirect immunofluorescence microscopy and flow cytometry following staining with a monoclonal antibody specific for CD46. Western transfer and immunoblotting detected a doublet of Mr 66,000 and 56,000.
D L, Gordon, T A, Sadlon, S L, Wesselingh, S M, Russell, R W, Johnstone, D F, Purcell   +5 more
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Identification and characterization of membrane cofactor protein (CD46) in the human kidneys

European Journal of Immunology, 1994
AbstractMembrane cofactor protein (MCP, CD46) is an integral protein that serves as a cofactor for factor I in inactivating C3b/C4b deposited on the same cell‐membrane as C3bi/C4c+C4d. This C3b/C4b inactivation is closely associated with self‐protection of host cells from autologous complement attack.
Isao Nakanishi, Abdelhakim Moutabarrik, Tomoko Hara, Michiyo Hatanaka, Terumasa Hayashi, Tatsuya Syouji, Noriyuki Okada, Eisaku Kitamura, Yoshiharu Tsubakihara, Misako Matsumoto, Tsukasa Seya   +10 more
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