Results 91 to 100 of about 666,510 (287)

The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites [PDF]

, 2001
Background Following cleavage by caspase 8, the C-terminus of Bid translocates from the cytosol to the mitochondria that is dependent upon structures formed by the mitochondrial-specific lipid cardiolipin. Once associated with mitochondria, truncated Bid
Michael Lutter, Guy A Perkins, Xiaodong Wang   +2 more
core   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Glycerolipid transfer for the building of membranes in plant cells. [PDF]

, 2007
Membranes of plant organelles have specific glycerolipid compositions. Selective distribution of lipids at the levels of subcellular organelles, membrane leaflets and membrane domains reflects a complex and finely tuned lipid homeostasis.
Block, Maryse, Jouhet, Juliette, Maréchal, Eric   +2 more
core   +3 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Lysosome-Mitochondrial Crosstalk in Cellular Stress and Disease

Antioxidants
The perception of lysosomes and mitochondria as entirely separate and independent entities that degrade material and produce ATP, respectively, has been challenged in recent years as not only more complex roles for both organelles, but also an ...
Szilvia Kiraly, Jack Stanley, Emily R. Eden   +2 more
doaj   +1 more source

Get Closer to the World of Contact Sites: A Beginner's Guide to Proximity-Driven Fluorescent Probes

Contact, 2022
To maintain cellular homeostasis and to coordinate the proper response to a specific stimulus, information must be integrated throughout the cell in a well-organized network, in which organelles are the crucial nodes and membrane contact sites are the ...
Elena Poggio, Marisa Brini, Tito Calì
doaj   +1 more source

Transport into mitochondria and intramitochondrial sorting of the Fe/S protein of ubiquinol-cytochrome c reductase [PDF]

, 1986
The Fe/S protein of complex III is encoded by a nuclear gene, synthesized in the cytoplasm as a precursor with a 32 residue amino-terminal extension, and transported to the outer surface of the inner mitochondrial membrane. Our data suggest the following
Beinert, Bell, Bradford, Böhni, Conboy, Daum, Dowhan, Dumont, Edwards, Fujiki, Gabellini, Gabellini, Gasser, Gasser, Guiard, Hallermayer, Harmey, Harnisch, Hauska, Hay, Hennig, Hennig, Horwich, Horwich, Hurt, Hurt, Hurt, Kaput, Karlsson, Kolansky, Korb, Laemmli, Lewin, Li, Li, McAda, Miura, Ohashi, Pelham, Pfanner, Ploegh, Rieske, Sadler, Schatz, Schleyer, Schleyer, Schmidt, Schmidt, Schnaitman, Sidhu, Taniuchi, Teintze, Tomita, Trumpower, van Loon, van Loon, von Jagow, Wachter, Zimmermann, Zwizinski, Zwizinski   +60 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions

eLife
Cell motility processes highly depend on the membrane distribution of Phosphoinositides, giving rise to cytoskeleton reshaping and membrane trafficking events. Membrane contact sites serve as platforms for direct lipid exchange and calcium fluxes between
Hugo Siegfried, Georges Farkouh, Rémi Le Borgne, Catherine Pioche-Durieu, Thaïs De Azevedo Laplace, Agathe Verraes, Lucien Daunas, Jean-Marc Verbavatz, Mélina L Heuzé   +8 more
doaj   +1 more source

Current and Emerging Approaches for Studying Inter-Organelle Membrane Contact Sites

Frontiers in Cell and Developmental Biology, 2020
Inter-organelle membrane contact sites (MCSs) are classically defined as areas of close proximity between heterologous membranes and established by specific proteins (termed tethers).
Xue Huang, Chen Jiang, Lihua Yu, Aimin Yang   +3 more
doaj   +1 more source