Results 81 to 90 of about 666,510 (287)
Distinct steps in the import of ADP/ATP carrier into mitochondria [PDF]
, 1987 Transport of the precursor to the ADP/ATP carrier from the cytosol into the mitochondrial inner membrane was resolved into several consecutive steps. The precursor protein was trapped at distinct stages of the import pathway and subsequently chased to ...
Neupert, Walter, Pfanner, Nikolaus
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Lipid Dynamics at Membrane Contact Sites
Annual Review of BiochemistryIn eukaryotes, lipid building blocks for cellular membranes are made largely in the endoplasmic reticulum and then redistributed to other organelles. Lipids are transported between organelles by vesicular trafficking or else by proteins located primarily at sites where different organelles are closely apposed.
Karin M, Reinisch +2 more
openaire +2 more sources
The Organization and Function of the Phagophore-ER Membrane Contact Sites
Contact, 2023 Macroautophagy is characterized by the de novo formation of double-membrane vesicles termed autophagosomes. The precursor structure of autophagosomes is a membrane cistern called phagophore, which elongates through a massive acquisition of lipids until ...
Prado Vargas Duarte, Fulvio Reggiori
doaj +1 more source
Characterization of AtDGK2 in relation to Contact Sites [PDF]
, 2019 Contact Sites are conserved cellular regions where two membranes of different organelles are very close but not merged. Contact sites between the endoplasmic reticulum (ER) and the plasma membrane (ER-PM CS) play important roles in metabolic functions ...
Botella-Mesa, Miguel Angel +2 more
core
The different facets of organelle interplay - an overview of organelle interactions [PDF]
, 2015 ReviewThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.Membrane-bound organelles such as mitochondria, peroxisomes, or the endoplasmic reticulum (ER) create distinct ...
Costello, JC +3 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Plant organelle dynamics: cytoskeletal control and membrane contact sites [PDF]
New Phytologist, 2018 Contents Summary 381 I. Introduction 381 II. Basic movement characteristics 382 III. Actin and associated motors, myosins, play a primary role in plant organelle movement and positioning 382 IV. Mechanisms of myosin recruitment: a tightly regulated system? 384 V. Microtubules, associated motors and interplay with actin 386 VI.
Perico, Chiara, Sparkes, Imogen
openaire +4 more sources
eLife, 2019 The voltage-gated K+ channel Kv2.1 serves a major structural role in the soma and proximal dendrites of mammalian brain neurons, tethering the plasma membrane (PM) to endoplasmic reticulum (ER). Although Kv2.1 clustering at neuronal ER-PM junctions (EPJs)
Nicholas C Vierra +4 more
doaj +1 more source