Results 71 to 80 of about 666,510 (287)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Import pathways of precursor proteins into mitochondria [PDF]

, 1988
The precursor of porin, a mitochondrial outer membrane protein, competes for the import of precursors destined for the three other mitochondrial compartments, including the Fe/S protein of the bc1- complex (intermembrane space), the ADP/ATP carrier ...
Neupert, Walter, Pfaller, Rupert, Pfanner, Nikolaus, Rassow, Joachim, Steger, Heinrich F.   +4 more
core  

A dynamic model of the mitochondrial protein import machinery [PDF]

, 1992
Many proteins are translocated into or across two mem-branes in order to reach their functional destination; these include many nuclear-encoded mitochondrial and chloro-plast proteins, as well as proteins transported into or across the outer membrane of ...
Baker, Bayer, Brdiczka, Filloux, Glick, Hackenbrock, Hartl, Hwang, Hwang, Kellems, Kiebler, Koronakis, Lill, Martin, Pfanner, Pugsley, Rassow, Rassow, Schleyer, Schwaiger, Sen, Söllner, Söllner, Van Venetie, Vestweber   +24 more
core   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Stable Integration of Inducible SPLICS Reporters Enables Spatio-Temporal Analysis of Multiple Organelle Contact Sites upon Modulation of Cholesterol Traffic

Cells, 2022
The study of organelle contact sites has received a great impulse due to increased interest in the understanding of their involvement in many disease conditions. Split-GFP-based contact sites (SPLICS) reporters emerged as essential tools to easily detect
Flavia Giamogante, Lucia Barazzuol, Elena Poggio, Marta Tromboni, Marisa Brini, Tito Calì   +5 more
doaj   +1 more source

Making the connection: How membrane contact sites have changed our view of organelle biology. [PDF]

Cell
Voeltz GK, Sawyer EM, Hajnóczky G, Prinz WA.   +3 more
europepmc   +2 more sources

Mitochondrial behaviour throughout the lytic cycle of Toxoplasma gondii [PDF]

, 2017
Mitochondria distribution in cells controls cellular physiology in health and disease. Here we describe the mitochondrial morphology and positioning found in the different stages of the lytic cycle of the eukaryotic single-cell parasite Toxoplasma gondii.
Lemgruber, Leandro, Ovciarikova, Jana, Sheiner, Lilach, Stilger, Krista L., Sullivan, William J.   +4 more
core   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Lipid Transfer Proteins and Membrane Contact Sites in Human Cancer

Frontiers in Cell and Developmental Biology, 2020
Lipid-transfer proteins (LTPs) were initially discovered as cytosolic factors that facilitate lipid transport between membrane bilayers in vitro. Since then, many LTPs have been isolated from bacteria, plants, yeast, and mammals, and extensively studied ...
Diego Peretti, SoHui Kim, Roberta Tufi, Sima Lev   +3 more
doaj   +1 more source

Two ancient membrane pores mediate mitochondrial-nucleus membrane contact sites. [PDF]

J Cell Biol
Coordination between nucleus and mitochondria is essential for cell survival, and thus numerous communication routes have been established between these two organelles over eukaryotic cell evolution. One route for organelle communication is via membrane contact sites, functional appositions formed by molecular tethers.
Ovciarikova J, Shikha S, Lacombe A, Courjol F, McCrone R, Hussain W, Maclean A, Lemgruber L, Martins-Duarte ES, Gissot M, Sheiner L.   +10 more
europepmc   +4 more sources