Results 51 to 60 of about 666,510 (287)

Nuclear Interactions: A Spotlight on Nuclear Mitochondrial Membrane Contact Sites

Contact, 2022
Membrane contact sites (MCS) are critical for cellular functions of eukaryotes, as they enable communication and exchange between organelles. Research over the last decade unravelled the function and composition of MCS between a variety of organelles ...
Jana Ovciarikova, Shikha Shikha, Lilach Sheiner   +2 more
doaj   +1 more source

Protein folding causes an arrest of preprotein translocation into mitochondria in vivo [PDF]

, 1991
With vital yeast cells, a hybrid protein consisting of the amino- terminal third of the precursor to cytochrome b2 and of the entire dihydrofolate reductase was arrested on the import pathway into mitochondria.
Becker, Karin, Guiard, Bernard, Horwich, Arthur, Neupert, Walter, Pfanner, Nikolaus, Schleyer, Manfred, Tropschug, Maximilian, Wienhues, Ulla   +7 more
core   +3 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Pex3 promotes formation of peroxisome-peroxisome and peroxisome-lipid droplet contact sites

Scientific Reports
Peroxisomes are ubiquitous organelles that mediate central metabolic functions, such as fatty acid β-oxidation, as well as diverse tissue- and organism-specific processes.
Lucía Amado, Louis Percifull, Rico Franzkoch, Vico Flatemersch, Eleni Joana Brüggemann, Olympia Ekaterini Psathaki, Maya Schuldiner, Maria Bohnert, Margret H. Bülow, Ayelén González Montoro   +9 more
doaj   +1 more source

Ultrastructural analysis of prostate cancer tissue provides insights into androgen-dependent adaptations to membrane contact site establishment

Frontiers in Oncology, 2023
Membrane trafficking and organelle contact sites are important for regulating cell metabolism and survival; processes often deregulated in cancer. Prostate cancer is the second leading cause of cancer-related death in men in the developed world.
Lisa M. Butler, Lisa M. Butler, Emma Evergren   +2 more
doaj   +1 more source

Translocation arrest by reversible folding of a precursor protein imported into mitochondria [PDF]

, 1989
Passage of precursor proteins through translocation contact sites of mitochondria was investigated by studying the import of a fusion protein consisting of the NH2-terminal 167 amino acids of yeast cytochrome b2 precursor and the complete mouse ...
Guiard, Bernard, Hartl, Franz-Ulrich, Herzog, Volker, Neupert, Walter, Rassow, Joachim, Wienhues, Ulla   +5 more
core  

The Arabidopsis Synaptotagmin1 is enriched in endoplasmic reticulum-plasma membrane contact sites and confers cellular resistance to mechanical stresses [PDF]

, 2015
Eukaryotic endoplasmic reticulum (ER)-plasma membrane (PM) contact sites are evolutionarily conserved microdomains that have important roles in specialized metabolic functions such as ER-PM communication, lipid homeostasis, and Ca2+ influx.
Botella, Miguel A, Esteban del Valle, Alicia, Friml, Jiri, Lee, Eunkyoung, McFarlane, Heather E, Pérez-Sancho, Jessica, Rosado, Abel, Valpuesta, Victoriano, Vanneste, Steffen   +8 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The Drosophila photoreceptor as a model system for studying signalling at membrane contact sites [PDF]

, 2016
Several recent studies have demonstrated the existence of membrane contact sites (MCS) between intracellular organelles in eukaryotic cells. Recent exciting studies have also demonstrated the existence of biomolecular interactions at these contact sites ...
Cockcroft, S, Raghu, P, Yadav, S
core   +1 more source