Results 21 to 30 of about 666,510 (287)
Inter-organelle membrane contact sites: implications for lipid metabolism
Biology Direct, 2020 This article supplements a recent Perspective by Scorrano et al. in Nature Communications [10 [ (1)]:1287] in which the properties and functions of inter-organelle membrane contact sites were summarized.
Jean E. Vance
doaj +1 more source
Plant Endoplasmic Reticulum–Plasma Membrane Contact Sites [PDF]
Trends in Plant Science, 2017 The endoplasmic reticulum (ER) acts as a superhighway with multiple sideroads that connects the different membrane compartments including the ER to the plasma membrane (PM). ER-PM contact sites (EPCSs) are a common feature in eukaryotic organisms, but have not been studied well in plants owing to the lack of molecular markers and to the difficulty in ...
Wang, P., Hawes, C., Hussey, P.J.
openaire +3 more sources
A morphological view on mitochondrial protein targeting [PDF]
, 1994 Mitochondrial protein targeting includes both intramitochondrial sorting of proteins encoded by the organellar genome and import and subsequent sorting of nuclear encoded precursor proteins. Only a few proteins are encoded by the mitochondrial genome and
Ades +55 more
core +1 more source
Sterol transporters at membrane contact sites regulate TORC1 and TORC2 signaling. [PDF]
, 2017 Membrane contact sites (MCSs) function to facilitate the formation of membrane domains composed of specialized lipids, proteins, and nucleic acids. In cells, membrane domains regulate membrane dynamics and biochemical and signaling pathways.
Murley, Andrew +6 more
core +1 more source
Membrane contact sites, gateways for lipid homeostasis [PDF]
Current Opinion in Cell Biology, 2015 Maintaining the proper lipid composition of cellular membranes is critical for numerous cellular processes but mechanisms of membrane lipid homeostasis are not well understood. There is growing evidence that membrane contact sites (MCSs), regions where two organelles come in close proximity to one another, play major roles in the regulation of ...
Sujoy, Lahiri +2 more
openaire +2 more sources
Endoplasmic Reticulum–Plasma Membrane Contact Sites
Annual Review of Biochemistry, 2017 The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms direct physical contacts with all other classes of membranous organelles, including the plasma membrane (PM). A number of protein tethers that mediate these contacts have been identified, and study of these protein tethers has revealed a multiplicity of roles in cell
Saheki, Yasunori, De Camilli, Pietro
openaire +4 more sources
Nature Communications, 2020 Interorganelle membrane contact sites between the endoplasmic reticulum and the endolysosome. Here, the authors show that ER-endolysosome membrane contact sites are promoted by the proteins protrudin and PDZD8 and may contribute to lipid extraction at ...
Michiko Shirane +10 more
doaj +1 more source
Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts. [PDF]
, 2015 Organelle contact sites perform fundamental functions in cells, including lipid and ion homeostasis, membrane dynamics, and signaling. Using a forward proteomics approach in yeast, we identified new ER-mitochondria and ER-vacuole contacts specified by an
Murley, Andrew +5 more
core +2 more sources
Frontiers in Cell and Developmental Biology, 2021 The endoplasmic reticulum (ER) forms direct membrane contact sites with the plasma membrane (PM) in eukaryotic cells. These ER-PM contact sites play essential roles in lipid homeostasis, ion dynamics, and cell signaling, which are carried out by protein ...
Chenlu Li +5 more
doaj +1 more source
Organelle remodeling at membrane contact sites [PDF]
Journal of Structural Biology, 2016 Cellular organelles must execute sophisticated biological processes to persist, and often communicate with one another to exchange metabolites and information. Recent studies suggest inter-organelle membrane contact sites (MCSs) are hubs for this cellular cross-talk.
openaire +2 more sources