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Virology, 2008 Infection by viruses having lipid-bilayer envelopes proceeds through fusion of the viral membrane with a membrane of the target cell. Viral 'fusion proteins' facilitate this process. They vary greatly in structure, but all seem to have a common mechanism of action, in which a ligand-triggered, large-scale conformational change in the fusion protein is ...
S. Harrison
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Current Opinion in Cell Biology, 2002 Fusion of biological membranes is governed by physical principles but it is unclear whether the transition states are primarily determined by lipid physics or by protein-lipid interactions. Recent advances in the field include the physical description of bilayer fusion, particularly new models beyond continuum models and the role of the SNARE proteins.
Jahn, R., Grubmueller, H.
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Membrane tension and membrane fusion [PDF]
Current Opinion in Structural Biology, 2015 Diverse cell biological processes that involve shaping and remodeling of cell membranes are regulated by membrane lateral tension. Here we focus on the role of tension in driving membrane fusion. We discuss the physics of membrane tension, forces that can generate the tension in plasma membrane of a cell, and the hypothesis that tension powers ...
Michael M, Kozlov +1 more
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From Population Averaging to Single Event Resolution: Evolution of Sensing Platforms for Membrane Fusion [PDF]
SensorsMembrane fusion is fundamental to intracellular transport and signal transduction, with its dysregulation implicated in various diseases. Deciphering its transient, microscale dynamics requires advanced sensing technologies.
Yazhuo Feng +4 more
doaj +2 more sources
Mechanisms of SNARE proteins in membrane fusion. [PDF]
Nat Rev Mol Cell Biol, 2023 Jahn R, Cafiso DC, Tamm LK.
europepmc +2 more sources
Control of artificial membrane fusion in physiological ionic solutions beyond the limits of electroformation [PDF]
Nature CommunicationsMembrane fusion, merging two lipid bilayers, is crucial for fabricating artificial membrane structures. Over the past 40 years, in contrast to precise and controllable membrane fusion in-vivo through specific molecules such as SNAREs, controlling the ...
Bong Kyu Kim +7 more
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Nature Structural & Molecular Biology, 2008 Subcellular compartmentalization, cell growth, hormone secretion and neurotransmission require rapid, targeted, and regulated membrane fusion. Fusion entails extensive lipid rearrangements by two apposed (docked) membrane vesicles, joining their membrane proteins and lipids and mixing their luminal contents without lysis.
William, Wickner, Randy, Schekman
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Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion
Science Advances, 2021 Prefusion human cytomegalovirus glycoprotein B structure reveals the structural basis for membrane fusion. Human cytomegalovirus (HCMV) causes congenital disease with long-term morbidity.
Yuhang Liu +7 more
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Simulation and prediction of membrane fusion dynamics
Theoretical and Applied Mechanics Letters, 2022 Membrane fusion is an important process by which biological membranes perform their life activities. Simulations show that the membrane fusion process happens mainly through three pathways, where the Stalk-Pore hypothesis, in which two membranes come ...
Zhi Zheng, Shouqin Lü, Mian Long
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Mechanism of Membrane Fusion: Interplay of Lipid and Peptide
Journal of Membrane Biology, 2022 Membrane fusion is an essential process for the survival of eukaryotes and the entry of enveloped viruses into host cells. A proper understanding of the mechanism of membrane fusion would provide us a handle to manipulate several biological pathways, and
Ankita Joardar +2 more
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