Results 1 to 10 of about 854,659 (323)
Virology, 2015 Infection by viruses having lipid-bilayer envelopes proceeds through fusion of the viral membrane with a membrane of the target cell. Viral 'fusion proteins' facilitate this process. They vary greatly in structure, but all seem to have a common mechanism of action, in which a ligand-triggered, large-scale conformational change in the fusion protein is ...
Stephen C. Harrison
openalex +4 more sources
Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion [PDF]
eLife, 2012 The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle–vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence of ...
Jiajie Diao +13 more
doaj +3 more sources
SARS-CoV-2 spike fusion peptide trans interaction with phosphatidylserine lipid triggers membrane fusion for viral entry [PDF]
mBioSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike is the fusion machine for host cell entry. Still, the mechanism by which spike protein interacts with the target lipid membrane to facilitate membrane fusion during entry is not fully ...
Puspangana Singh +6 more
doaj +2 more sources
Tracking the protein conformational motions driving HIV-1 membrane fusion [PDF]
Scientific ReportsHIV-1 Env (trimeric gp120/gp41) is the surface protein responsible for membrane fusion. The Env binds to the receptor proteins, which induces gp120 shedding leading to conformational changes of gp41 from the pre-fusion to post-fusion state, allowing its ...
Ilona C. Unarta +2 more
doaj +2 more sources
Control of artificial membrane fusion in physiological ionic solutions beyond the limits of electroformation [PDF]
Nature CommunicationsMembrane fusion, merging two lipid bilayers, is crucial for fabricating artificial membrane structures. Over the past 40 years, in contrast to precise and controllable membrane fusion in-vivo through specific molecules such as SNAREs, controlling the ...
Bong Kyu Kim +7 more
doaj +2 more sources
Nature Structural & Molecular Biology, 2008 Subcellular compartmentalization, cell growth, hormone secretion and neurotransmission require rapid, targeted, and regulated membrane fusion. Fusion entails extensive lipid rearrangements by two apposed (docked) membrane vesicles, joining their membrane proteins and lipids and mixing their luminal contents without lysis.
William, Wickner, Randy, Schekman
+7 more sources
Secretory vesicles are preferentially targeted to areas of low molecular SNARE density [PDF]
, 2012 Intercellular communication is commonly mediated by the regulated fusion, or exocytosis, of vesicles with the cell surface. SNARE (soluble N-ethymaleimide sensitive factor attachment protein receptor) proteins are the catalytic core of the secretory ...
Dun, Alison +8 more
core +17 more sources
A broadly neutralizing antibody confers cross-genus protection against alphaherpesviruses by inhibiting gB-mediated membrane fusion. [PDF]
Nat CommunWang G +27 more
europepmc +3 more sources
Simulation and prediction of membrane fusion dynamics
Theoretical and Applied Mechanics Letters, 2022 Membrane fusion is an important process by which biological membranes perform their life activities. Simulations show that the membrane fusion process happens mainly through three pathways, where the Stalk-Pore hypothesis, in which two membranes come ...
Zhi Zheng, Shouqin Lü, Mian Long
doaj +1 more source
Cell, 2003 Membrane fusion, one of the most fundamental processes in life, occurs when two separate lipid membranes merge into a single continuous bilayer. Fusion reactions share common features, but are catalyzed by diverse proteins. These proteins mediate the initial recognition of the membranes that are destined for fusion and pull the membranes close together
Jahn, R., Lang, T., Suedhof, T.
openaire +3 more sources