Results 91 to 100 of about 2,473,220 (258)

A novel soluble analog of the HIV-1 fusion cofactor, globotriaosylceramide (Gb3), eliminates the cholesterol requirement for high affinity gp120/Gb3 interaction

Journal of Lipid Research, 2002
We have analyzed the interaction of adamantyl Gb3 (adaGb3), a semi-synthetic soluble analog of Gb3, with HIV-1 surface envelope glycoprotein gp120. In this analog, which was orginally designed to inhibit verotoxin binding to its glycolipid receptor, Gb3,
Radhia Mahfoud, Murugesapillai Mylvaganam, Clifford A. Lingwood, Jacques Fantini   +3 more
doaj   +1 more source

Caveolin limits membrane microdomain mobility and integrin-mediated uptake of fibronectin-binding pathogens

Journal of Cell Science, 2010
Staphylococcus aureus, which is a leading cause of hospital-acquired infections, binds via fibronectin to integrin α5β1, a process that can promote host colonization in vivo.
C. Hoffmann, Anne D. Berking, F. Agerer, Alexander Buntru, F. Neske, G. S. Chhatwal, K. Ohlsen, C. Hauck   +7 more
semanticscholar   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Molecular dynamics exploration of poration and leaking caused by Kalata B1 in HIV-infected cell membrane compared to host and HIV membranes

Scientific Reports, 2017
The membrane disruption activities of kalata B1 (kB1) were investigated using molecular dynamics simulations with membrane models. The models were constructed to mimic the lipid microdomain formation in membranes of HIV particle, HIV-infected cell, and ...
Wanapinun Nawae, Supa Hannongbua, Marasri Ruengjitchatchawalya   +2 more
doaj   +1 more source

Label‐Free Molecular Characterization of Protein Aggregates in Differentiated Astrocytes

Advanced Science, EarlyView.
Mid‐infrared photothermal microscopy enables label‐free structural, molecular, and functional imaging of protein aggregates in astrocyte cells. The processes of astrocytes differentiated on a nanomaterial interface are characterized by α‐helical signatures combined with enhanced interfacial thermal resistance properties, while the cell soma of non ...
Panagis D. Samolis, Chiara Lazzarini, Rahmetullah Durgun, Barbara Barile, Giorgia Conte, Tamara Posati, Marco Caprini, Grazia Paola Nicchia, Valentina Benfenati, Michelle Y. Sander   +9 more
wiley   +1 more source

Coordination of bilayer properties by an inward-rectifier K+ channel is a cooperative process driven by protein-lipid interaction

Journal of Structural Biology: X
Physical properties of biological membranes directly or indirectly govern biological processes. Yet, the interplay between membrane and integral membrane proteins is difficult to assess due to reciprocal effects between membrane proteins, individual ...
Evan J. van Aalst, Maryam Yekefallah, Roy A. M. van Beekveld, Eefjan Breukink, Markus Weingarth, Benjamin J. Wylie   +5 more
doaj   +1 more source

Contributions of quantitative proteomics to understanding membrane microdomains

Journal of Lipid Research, 2009
Membrane microdomains, e.g., lipid rafts and caveolae, are crucial cell surface organelles responsible for many cellular signaling and communication events, which makes the characterization of their proteomes both interesting and valuable. They are large
Yu Zi Zheng, Leonard J. Foster
doaj   +1 more source

Analysis of acid-tolerance mechanism based on membrane microdomains in Saccharomyces cerevisiae

Microbial Cell Factories, 2023
Background Saccharomyces cerevisiae has been used in the biosynthesis of acid products such as organic acids owing to its acid tolerance. Improving the acid tolerance of S. cerevisiae is beneficial for expanding its application range.
Xueqin Lv, Ke Jin, Yu Yi, Lingang Song, Xiang Xiu, Yanfeng Liu, Jianghua Li, Guocheng Du, Jian Chen, Long Liu   +9 more
doaj   +1 more source

Lipid rafts: The enigmatic membrane microdomain [PDF]

The Biochemist, 2009
In the field of membrane biology, perhaps one of the most controversial concepts in recent years has been the enigmatic membrane microdomain, the cholesterol- and glycosphingolipid-rich lipid raft.
David R. Taylor, Nigel M. Hooper
openaire   +1 more source

Insulin Signaling in Microdomains of the Plasma Membrane [PDF]

Traffic, 2003
Although the effects of insulin on glucose and lipid metabolism are well documented, gaps remain in our understanding of the precise molecular mechanisms of signal transduction. Recent evidence suggests that compartmentalization of signaling molecules and metabolic enzymes may explain the unique cellular effects of the hormone.
Saltiel, Alan R., Pessin, Jeffrey E.
openaire   +3 more sources