The tetherin/BST-2 coiled-coil ectodomain mediates plasma membrane microdomain localization and restriction of particle release. [PDF]
J Virol, 2012 Hammonds J +7 more
europepmc +2 more sources
Host cell membrane microdomains and fungal infection [PDF]
Cellular Microbiology, 2021 Lipid microdomains or lipid rafts are dynamic and tightly ordered regions of the plasma membrane. In mammalian cells, they are enriched in cholesterol, glycosphingolipids, Glycosylphosphatidylinositol-anchored and signalling-related proteins. Several studies have suggested that mammalian pattern recognition receptors are concentrated or recruited to ...
Taiane N. Souza +6 more
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Lipid raft localization of TLR2 and its co-receptors is independent of membrane lipid composition [PDF]
PeerJ, 2018 Background Toll like receptors (TLRs) are an important and evolutionary conserved class of pattern recognition receptors associated with innate immunity. The recognition of Gram-positive cell wall constituents strongly depends on TLR2.
Christine Hellwing +4 more
doaj +2 more sources
Single-molecule microscopy reveals membrane microdomain organization of cells in a living vertebrate. [PDF]
Biophys J, 2009 Schaaf MJ +6 more
europepmc +2 more sources
Functional microdomains in bacterial membranes [PDF]
Genes & Development, 2010 The membranes of eukaryotic cells harbor microdomains known as lipid rafts that contain a variety of signaling and transport proteins. Here we show that bacterial membranes contain microdomains functionally similar to those of eukaryotic cells. These membrane microdomains from diverse bacteria harbor homologs of Flotillin-1, a eukaryotic protein found ...
López, Daniel, Kolter, Roberto
openaire +3 more sources
TrpML-mediated astrocyte microdomain Ca2+ transients regulate astrocyte–tracheal interactions
eLife, 2020 Astrocytes exhibit spatially-restricted near-membrane microdomain Ca2+transients in their fine processes. How these transients are generated and regulate brain function in vivo remains unclear. Here we show that Drosophila astrocytes exhibit spontaneous,
Zhiguo Ma, Marc R Freeman
doaj +1 more source
Platelet activating factor-induced ceramide micro-domains drive endothelial NOS activation and contribute to barrier dysfunction. [PDF]
PLoS ONE, 2013 The spatial and functional relationship between platelet activating factor-receptor (PAF-R) and nitric oxide synthase (eNOS) in the lateral plane of the endothelial plasma membrane is poorly characterized.
Sanda Predescu +5 more
doaj +1 more source
Tight junctions are membrane microdomains [PDF]
Journal of Cell Science, 2000 ABSTRACT Tight junctions (TJ) of polarized epithelial cells regulate barrier function at mucosal surfaces. Structural proteins of TJs include hyperphosphorylated occludin (HO) and the peripheral membrane protein, ZO-1. Since TJs are dynamically regulated, and lipid-modified signal transduction proteins localize to TJs, we considered the ...
A, Nusrat +7 more
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Membrane microdomains in immunoreceptor signaling [PDF]
FEBS Letters, 2014 Membrane microdomains denoted commonly as lipid rafts (or membrane rafts) have been implicated in T‐cell receptor (TCR), and more generally immunoreceptor, signaling for over 25 years. However, this area of research has been complicated by doubts about the real nature (and even existence) of these membrane entities, especially because of methodological
Horejsi, Vaclav, Hrdinka, Matous
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Membrane microdomains: from seeing to understanding [PDF]
Frontiers in Plant Science, 2014 The plasma membrane is a composite material, which forms a semi-permeable barrier and an interface for communication between the intracellular and extracellular environments. While the existence of membrane microdomains with nanoscale organization has been proved by the application of numerous biochemical and physical methods, direct observation of ...
Truong-Quang, Binh-An +1 more
openaire +3 more sources