Membrane Microdomain Disassembly Inhibits MRSA Antibiotic Resistance. [PDF]
Cell, 2017 A number of bacterial cell processes are confined functional membrane microdomains (FMMs), structurally and functionally similar to lipid rafts of eukaryotic cells. How bacteria organize these intricate platforms and what their biological significance is remain important questions.
García-Fernández E +10 more
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Animal Cell Cytokinesis: The Rho-Dependent Actomyosin-Anilloseptin Contractile Ring as a Membrane Microdomain Gathering, Compressing, and Sorting Machine [PDF]
Frontiers in Cell and Developmental Biology, 2020 Cytokinesis is the last step of cell division that partitions the cellular organelles and cytoplasm of one cell into two. In animal cells, cytokinesis requires Rho-GTPase-dependent assembly of F-actin and myosin II (actomyosin) to form an equatorial ...
Sabrya C. Carim +3 more
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Detergent-resistant plasma membrane proteomes for elucidating microdomain functions in plant cells [PDF]
Frontiers in Plant Science, 2013 Although proteins and lipids have been assumed to be distributed homogeneously in the plasma membrane (PM), recent studies suggest that the PM is non-uniform, forming a structure that includes a number of lateral domains enriched in specific components ...
Daisuke eTakahashi +4 more
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The cytosolic N-terminus of CD317/tetherin is a membrane microdomain exclusion motif [PDF]
Biology Open, 2013 Summary The integral membrane protein CD317/tetherin has been associated with a plethora of biological processes, including restriction of enveloped virus release, regulation of B cell growth, and organisation of membrane microdomains.
Peter G. Billcliff +3 more
doaj +2 more sources
Fluorescent probes for the visualization of membrane microdomain, deformation, and fusion [PDF]
Smart MoleculesThe cell membrane, a fluid interface composed of self‐assembled phospholipid molecules, is a vital component of biological systems that maintains cellular stability and prevents the invasion of foreign toxins.
Pei‐Hong Tong +6 more
doaj +2 more sources
Molecular mechanisms of flotillin complexes in organizing membrane microdomains [PDF]
Nature CommunicationsFlotillin-1 and flotillin-2 form hetero-oligomers to create flotillin membrane microdomains essential for endocytosis and protein sorting. However, the mechanisms of flotillin oligomerization and microdomain organization remain incompletely understood ...
Ming-Ao Lu +7 more
doaj +2 more sources
Structural basis for membrane microdomain formation by a human Stomatin complex [PDF]
Nature CommunicationsBiological membranes are not just passive barriers—they actively sense and respond to mechanical forces, in part through specialized proteins embedded within them.
Jack Stoner, Shufang Li, Ziao Fu
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Host cell membrane microdomains and fungal infection [PDF]
Cellular Microbiology, 2021 Lipid microdomains or lipid rafts are dynamic and tightly ordered regions of the plasma membrane. In mammalian cells, they are enriched in cholesterol, glycosphingolipids, Glycosylphosphatidylinositol-anchored and signalling-related proteins. Several studies have suggested that mammalian pattern recognition receptors are concentrated or recruited to ...
Taiane N. Souza +6 more
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Lipid raft localization of TLR2 and its co-receptors is independent of membrane lipid composition [PDF]
PeerJ, 2018 Background Toll like receptors (TLRs) are an important and evolutionary conserved class of pattern recognition receptors associated with innate immunity. The recognition of Gram-positive cell wall constituents strongly depends on TLR2.
Christine Hellwing +4 more
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Functional microdomains in bacterial membranes [PDF]
Genes & Development, 2010 The membranes of eukaryotic cells harbor microdomains known as lipid rafts that contain a variety of signaling and transport proteins. Here we show that bacterial membranes contain microdomains functionally similar to those of eukaryotic cells. These membrane microdomains from diverse bacteria harbor homologs of Flotillin-1, a eukaryotic protein found ...
López, Daniel, Kolter, Roberto
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