Results 31 to 40 of about 232,617 (270)
Membrane microdomains and insulin resistance [PDF]
FEBS Letters, 2009 A new concept, that “metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides”, has arisen. By examining this working hypothesis, we demonstrate the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and gangliosides ...
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A compact, multifunctional fusion module directs cholesterol-dependent homomultimerization and syncytiogenic efficiency of reovirus p10 FAST proteins. [PDF]
PLoS Pathogens, 2014 The homologous p10 fusion-associated small transmembrane (FAST) proteins of the avian (ARV) and Nelson Bay (NBV) reoviruses are the smallest known viral membrane fusion proteins, and are virulence determinants of the fusogenic reoviruses.
Tim Key, Roy Duncan
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Journal of Lipid Research, 2015 α-Tocopherol (vitamin E) has attracted considerable attention as a potential protective or palliative agent. In vitro, its free radical-scavenging antioxidant action has been widely demonstrated.
Sterenn Davis +6 more
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Fats and function:protein lipid modifications in plant cell signalling [PDF]
, 2017 The post-translational lipid modifications N-myristoylation, prenylation and S-acylation are traditionally associated with increasing protein membrane affinity.
Adjobo-Hermans +54 more
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Tracking microdomain dynamics in cell membranes
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2009 Studies of the diffusion of proteins and lipids in the plasma membrane of cells have long pointed to the presence of membrane domains. A major challenge in the field of membrane biology has been to characterize the various cellular structures and mechanisms that impede free diffusion in cell membranes and determine the consequences that membrane ...
Day, Charles A., Kenworthy, Anne K.
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Multiple Kv1.5 targeting to membrane surface microdomains [PDF]
Journal of Cellular Physiology, 2008 AbstractSurface expression of voltage‐dependent K+ channels (Kv) has a pivotal role in leukocyte physiology. Although little is known about the physiological role of lipid rafts, these microdomains concentrate signaling molecules and their ion channel substrates. Kv1.3 associates with Kv1.5 to form functional channels in macrophages.
Martinez-Marmol, Ramon +6 more
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Membrane Microdomains and Vascular Biology [PDF]
Circulation, 2003 The classic model of cell plasma membrane organization is that of a uniform, fluid environment in which protein and lipid constituents diffuse rapidly in an unrestricted fashion. Recent experimental evidence, however, reveals a far more complex membrane organization consisting of microdomains assembled from lipid constituents that have distinct ...
R Preston, Mason, Robert F, Jacob
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Role of MCC/Eisosome in Fungal Lipid Homeostasis
Biomolecules, 2019 One of the best characterized fungal membrane microdomains is the MCC/eisosome. The MCC (membrane compartment of Can1) is an evolutionarily conserved ergosterol-rich plasma membrane domain.
Jakub Zahumensky, Jan Malinsky
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Ca2+ tunnelling through the ER lumen as a mechanism for delivering Ca2+ entering via store-operated Ca2+ channels to specific target sites [PDF]
, 2017 Ca2+ signaling is perhaps the most universal and versatile mechanism regulating a wide range of cellular processes. Because of the many different calcium-binding proteins distributed throughout cells, signaling precision requires localized rises in the ...
Courjaret, Raphael +2 more
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A Localized Complex of Two Protein Oligomers Controls the Orientation of Cell Polarity
mBio, 2017 Signaling hubs at bacterial cell poles establish cell polarity in the absence of membrane-bound compartments. In the asymmetrically dividing bacterium Caulobacter crescentus, cell polarity stems from the cell cycle-regulated localization and turnover of ...
Adam M. Perez +5 more
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