Results 51 to 60 of about 232,617 (270)
Frontiers in Aging Neuroscience, 2021 Neurodegenerative diseases are a class of slow-progressing terminal illnesses characterized by neuronal lesions, such as multiple sclerosis [MS, Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS)]. Their incidence
Wen Yu +16 more
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Presynaptic nanodomains : a tale of two synapses [PDF]
, 2015 © The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Frontiers in Cellular Neuroscience 8 (2015): 455, doi:10.3389/fncel.2014.00455.Here we summarize the ...
Augustine, George J., Wang, Lu-Yang
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Metabotropic Purinergic Receptors in Lipid Membrane Microdomains
Current Medicinal Chemistry, 2012 There is broad evidence that association of transmembrane receptors and signalling molecules with lipid rafts/caveolae provides an enriched environment for protein-protein interactions necessary for signal transduction, and a mechanism for the modulation of neurotransmitter and/or growth factor receptor function.
D' Ambrosi, N, Volonte, C
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Inferring Maps of Forces Inside Cell Membrane Microdomains [PDF]
Biophysical Journal, 2009 Mapping of the forces on biomolecules in cell membranes has spurred the development of effective labels, e.g. organic fluorophores and nanoparticles, to track trajectories of single biomolecules. Standard methods use particular statistics, namely the mean square displacement, to analyze the underlying dynamics.
Masson, J.-B. +6 more
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Biology Open, 2019 Specialized microdomains which have cholesterol-rich membrane regions contain transient receptor potential vanilloid subtype 1 (TRPV1) are involved in pain development.
Chih-Lung Lin +4 more
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Structural and functional glycosphingolipidomics by glycoblotting with aminooxy-functionalized gold nanoparticle [PDF]
, 2008 Glycosphingolipids (GSLs) synthesized in Golgi apparatus by sequential transfer of sugar residues to a ceramide lipid anchor are ubiquitously distributing on vertebrate plasma membranes.
Midori Abe +2 more
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Membrane microdomains and cAMP compartmentation
The FASEB Journal, 2012 The role of different membrane domains in the compartmentation of cAMP signaling was investigated using the FRET‐based Epac2‐ camps biosensor. The MyrPalm sequence from Lyn kinase and the CAAX sequence from Rho GTPase were used to target this probe to lipid raft (Epac2‐MyrPalm) or non‐lipid raft (Epac2‐CAAX) membrane domains in HEK293 cells.
Shailesh Agarwal +6 more
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CD317/Tetherin is an organiser of membrane microdomains [PDF]
Journal of Cell Science, 2013 The integral membrane protein tetherin has been associated with an eclectic mix of cellular processes, including restricting the release of a range of enveloped viruses from infected cells. The unusual topology of tetherin (it possesses both a conventional transmembrane domain and a glycosylphosphatidylinositol anchor), its localisation to membrane ...
Billcliff, Peter G. +5 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
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Pressure-dependent regulation of Ca2+ signaling in the vascular endothelium [PDF]
, 2015 The endothelium is an interconnected network upon which hemodynamic mechanical forces act to control vascular tone and remodeling in disease. Ca2+ signaling is central to the endothelium's mechanotransduction and networked activity.
Girkin, John M. +3 more
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