LPS- or Pseudomonas aeruginosa-mediated activation of the macrophage TLR4 signaling cascade depends on membrane lipid composition [PDF]
PeerJ, 2016 It is well known that PUFA impede the LPS-mediated activation of the transcription factor NFkappaB. However, the underlying mode of action has not been clarified yet. To address this issue in a comprehensive approach, we used the monocyte/macrophage cell
Axel Schoeniger +2 more
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Journal of Lipid Research, 2005 The formation of hepatic bile requires that water be transported across liver epithelia. Rat hepatocytes express three aquaporins (AQPs): AQP8, AQP9, and AQP0. Recognizing that cholesterol and sphingolipids are thought to promote the assembly of proteins
P. Tietz +3 more
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Analysis of lipid-composition changes in plasma membrane microdomains[S]
Journal of Lipid Research, 2015 Sphingolipids accumulate in plasma membrane microdomain sites, such as caveolae or lipid rafts. Such microdomains are considered to be important nexuses for signal transduction, although changes in the microdomain lipid components brought about by ...
Hideo Ogiso +2 more
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Reversible Dissolution of Microdomains in Detergent-Resistant Membranes at Physiological Temperature. [PDF]
PLoS ONE, 2015 The formation of lipid microdomains ("rafts") is presumed to play an important role in various cellular functions, but their nature remains controversial.
Andrea Cremona +4 more
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Stepping between Membrane Microdomains [PDF]
Biophysical Journal, 2015 Lateral membrane microdomains are postulated to be involved in a number of important functions in mammalian cells, such as membrane trafficking, exocytosis, endocytosis, signal transduction, and protein activity (1,2). These putative cell microdomains have been the subject of extensive research using a variety of biophysical and biochemical techniques,
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Biological and Cellular Functions of the Microdomain-Associated FWL/CNR Protein Family in Plants
Plants, 2020 Membrane microdomains/nanodomains are sub-compartments of the plasma membrane enriched in sphingolipids and characterized by their unique protein composition.
Sandra Thibivilliers +2 more
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Detergent-resistant plasma membrane proteomes for elucidating microdomain functions in plant cells
Frontiers in Plant Science, 2013 Although proteins and lipids have been assumed to be distributed homogeneously in the plasma membrane (PM), recent studies suggest that the PM is non-uniform, forming a structure that includes a number of lateral domains enriched in specific components ...
Daisuke eTakahashi +4 more
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Structure and function of the membrane microdomains in osteoclasts
Bone Research, 2023 The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed in the clinic and is an important target to the development of therapeutic strategies for these diseases.
Jialong Hou +8 more
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Journal of Lipid Research, 2015 α-Tocopherol (vitamin E) has attracted considerable attention as a potential protective or palliative agent. In vitro, its free radical-scavenging antioxidant action has been widely demonstrated.
Sterenn Davis +6 more
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A compact, multifunctional fusion module directs cholesterol-dependent homomultimerization and syncytiogenic efficiency of reovirus p10 FAST proteins. [PDF]
PLoS Pathogens, 2014 The homologous p10 fusion-associated small transmembrane (FAST) proteins of the avian (ARV) and Nelson Bay (NBV) reoviruses are the smallest known viral membrane fusion proteins, and are virulence determinants of the fusogenic reoviruses.
Tim Key, Roy Duncan
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