Results 41 to 50 of about 2,473,220 (258)
Membrane microdomains and insulin resistance [PDF]
FEBS Letters, 2009 A new concept, that “metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides”, has arisen. By examining this working hypothesis, we demonstrate the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and gangliosides ...
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Tracking microdomain dynamics in cell membranes
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2009 Studies of the diffusion of proteins and lipids in the plasma membrane of cells have long pointed to the presence of membrane domains. A major challenge in the field of membrane biology has been to characterize the various cellular structures and mechanisms that impede free diffusion in cell membranes and determine the consequences that membrane ...
Day, Charles A., Kenworthy, Anne K.
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Multiple Kv1.5 targeting to membrane surface microdomains [PDF]
Journal of Cellular Physiology, 2008 AbstractSurface expression of voltage‐dependent K+ channels (Kv) has a pivotal role in leukocyte physiology. Although little is known about the physiological role of lipid rafts, these microdomains concentrate signaling molecules and their ion channel substrates. Kv1.3 associates with Kv1.5 to form functional channels in macrophages.
Martinez-Marmol, Ramon +6 more
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Role of MCC/Eisosome in Fungal Lipid Homeostasis
Biomolecules, 2019 One of the best characterized fungal membrane microdomains is the MCC/eisosome. The MCC (membrane compartment of Can1) is an evolutionarily conserved ergosterol-rich plasma membrane domain.
Jakub Zahumensky, Jan Malinsky
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Membrane Microdomains and Vascular Biology [PDF]
Circulation, 2003 The classic model of cell plasma membrane organization is that of a uniform, fluid environment in which protein and lipid constituents diffuse rapidly in an unrestricted fashion. Recent experimental evidence, however, reveals a far more complex membrane organization consisting of microdomains assembled from lipid constituents that have distinct ...
R Preston, Mason, Robert F, Jacob
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Overexpression of BAX INHIBITOR-1 Links Plasma Membrane Microdomain Proteins to Stress1[OPEN]
Plant Physiology, 2015 Overexpression of a cell death suppressor modulates sphingolipid and protein composition of plasma membrane microdomains, leading to enhanced tolerance to stress.
T. Ishikawa +4 more
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A Localized Complex of Two Protein Oligomers Controls the Orientation of Cell Polarity
mBio, 2017 Signaling hubs at bacterial cell poles establish cell polarity in the absence of membrane-bound compartments. In the asymmetrically dividing bacterium Caulobacter crescentus, cell polarity stems from the cell cycle-regulated localization and turnover of ...
Adam M. Perez +5 more
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The membrane-associated form of α(s1)-casein interacts with cholesterol-rich detergent-resistant microdomains. [PDF]
PLoS ONE, 2014 Caseins, the main milk proteins, interact with colloidal calcium phosphate to form the casein micelle. The mesostructure of this supramolecular assembly markedly influences its nutritional and technological functionalities.
Annabelle Le Parc +5 more
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A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
eLife, 2022 Activating mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease, and previously we showed that activated LRRK2 phosphorylates a subset of Rab GTPases (Steger et al., 2017).
Edmundo G Vides +10 more
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Immunity, 1998 The linker molecule LAT is a critical substrate of the tyrosine kinases activated upon TCR engagement. Phosphorylated LAT binds Grb2, PLC-gamma1, and other signaling molecules.
Weiguo Zhang, R. Trible, L. Samelson
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