Results 51 to 60 of about 2,473,220 (258)

The Involvement of Lactosylceramide in Central Nervous System Inflammation Related to Neurodegenerative Disease

Frontiers in Aging Neuroscience, 2021
Neurodegenerative diseases are a class of slow-progressing terminal illnesses characterized by neuronal lesions, such as multiple sclerosis [MS, Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS)]. Their incidence
Wen Yu, Wen Yu, Jun Ying, Jun Ying, Xifeng Wang, Xing Liu, Xing Liu, Tiancheng Zhao, Sungtae Yoon, Qingcui Zheng, Qingcui Zheng, Yang Fang, Yang Fang, Danying Yang, Danying Yang, Fuzhou Hua, Fuzhou Hua   +16 more
doaj   +1 more source

Membrane microdomains emergence through non-homogeneous diffusion [PDF]

BMC Biophysics, 2012
In the classical view, cell membrane proteins undergo isotropic random motion, that is a 2D Brownian diffusion that should result in an homogeneous distribution of concentration. It is, however, far from the reality: Membrane proteins can assemble into so-called microdomains (sometimes called lipid rafts) which also display a specific lipid composition.
Soula, Hédi, Coulon, Antoine, Beslon, Guillaume   +2 more
openaire   +5 more sources

Plasma membrane microdomains in aging and disease [PDF]

Geriatrics & Gerontology International, 2010
The plasma membrane of eukaryotic cells participates in signal transduction and many other cellular events to maintain the physiological state of cells. In recent decades, much attention has been paid to membrane microdomains, called lipid rafts or membrane rafts, as signaling platforms in the plasma membrane.
Yoshiko, Ohno-Iwashita, Yukiko, Shimada, Masami, Hayashi, Mitsushi, Inomata   +3 more
openaire   +2 more sources

Treatment with methyl-β-cyclodextrin prevents mechanical allodynia in resiniferatoxin neuropathy in a mouse model

Biology Open, 2019
Specialized microdomains which have cholesterol-rich membrane regions contain transient receptor potential vanilloid subtype 1 (TRPV1) are involved in pain development.
Chih-Lung Lin, Chin-Hong Chang, Ying-Shuang Chang, Shui-Chin Lu, Yu-Lin Hsieh   +4 more
doaj   +1 more source

Metabotropic Purinergic Receptors in Lipid Membrane Microdomains

Current Medicinal Chemistry, 2012
There is broad evidence that association of transmembrane receptors and signalling molecules with lipid rafts/caveolae provides an enriched environment for protein-protein interactions necessary for signal transduction, and a mechanism for the modulation of neurotransmitter and/or growth factor receptor function.
D' Ambrosi, N, Volonte, C
openaire   +4 more sources

Inferring Maps of Forces Inside Cell Membrane Microdomains [PDF]

Biophysical Journal, 2009
Mapping of the forces on biomolecules in cell membranes has spurred the development of effective labels, e.g. organic fluorophores and nanoparticles, to track trajectories of single biomolecules. Standard methods use particular statistics, namely the mean square displacement, to analyze the underlying dynamics.
Masson, J.-B., Casanova, Didier, Türkcan, Silvan, Voisinne, G., Popoff, Michel, Vergassola, M., Alexandrou, Antigoni   +6 more
openaire   +5 more sources

Membrane microdomains and cAMP compartmentation

The FASEB Journal, 2012
The role of different membrane domains in the compartmentation of cAMP signaling was investigated using the FRET‐based Epac2‐ camps biosensor. The MyrPalm sequence from Lyn kinase and the CAAX sequence from Rho GTPase were used to target this probe to lipid raft (Epac2‐MyrPalm) or non‐lipid raft (Epac2‐CAAX) membrane domains in HEK293 cells.
Shailesh Agarwal, Kacie Caldwell, Ashley Owens, Cherie Singer, Viacheslav Nikolaev, Martin Lohse, Robert Harvey   +6 more
openaire   +1 more source

CD317/Tetherin is an organiser of membrane microdomains [PDF]

Journal of Cell Science, 2013
The integral membrane protein tetherin has been associated with an eclectic mix of cellular processes, including restricting the release of a range of enveloped viruses from infected cells. The unusual topology of tetherin (it possesses both a conventional transmembrane domain and a glycosylphosphatidylinositol anchor), its localisation to membrane ...
Billcliff, Peter G., Rollason, Ruth, Prior, Ian, Owen, Dylan M., Gaus, Katharina, Banting, George   +5 more
openaire   +3 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Electroactive Liquid Crystal Elastomers as Soft Actuators

Advanced Functional Materials, EarlyView.
Electroactive liquid crystal elastomers (eLCEs) can be actuated via electromechanical, electrochemical, or electrothermal effects. a) Electromechanical effects include Maxwell stress, electrostriction, and the electroclinic effect. b) Electrochemical effects arise from electrode redox reactions.
Yakui Deng, Min‐Hui Li
wiley   +1 more source