Results 61 to 70 of about 2,473,220 (258)

Fish oil increases raft size and membrane order of B cells accompanied by differential effects on function

Journal of Lipid Research, 2012
Fish oil (FO) targets lipid microdomain organization to suppress T-cell and macrophage function; however, little is known about this relationship with B cells, especially at the animal level. We previously established that a high FO dose diminished mouse
Benjamin Drew Rockett, Heather Teague, Mitchel Harris, Mark Melton, Justin Williams, Stephen R. Wassall, Saame Raza Shaikh   +6 more
doaj   +1 more source

Adenosine receptors and membrane microdomains

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011
Adenosine receptors are a member of the large family of seven transmembrane spanning G protein coupled receptors. The four adenosine receptor subtypes-A(1), A(2a), A(2b), A(3)-exert their effects via the activation of one or more heterotrimeric G proteins resulting in the modulation of intracellular signaling. Numerous studies over the past decade have
openaire   +2 more sources

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β2AR-cAMP Responsiveness in Murine Hearts

Cell Reports, 2018
Summary: Cardiomyocytes from the apex but not the base of the heart increase their contractility in response to β2-adrenoceptor (β2AR) stimulation, which may underlie the development of Takotsubo cardiomyopathy.
Peter T. Wright, Navneet K. Bhogal, Ivan Diakonov, Laura M.K. Pannell, Ruwan K. Perera, Nadja I. Bork, Sophie Schobesberger, Carla Lucarelli, Giuseppe Faggian, Anita Alvarez-Laviada, Manuela Zaccolo, Timothy J. Kamp, Ravi C. Balijepalli, Alexander R. Lyon, Sian E. Harding, Viacheslav O. Nikolaev, Julia Gorelik   +16 more
doaj   +1 more source

Sphingolipids: membrane microdomains in brain development, function and neurological diseases [PDF]

Open Biology, 2017
Sphingolipids are highly enriched in the nervous system where they are pivotal constituents of the plasma membranes and are important for proper brain development and functions. Sphingolipids are not merely structural elements, but are also recognized as
Anne S. B. Olsen, Nils J. Færgeman
doaj   +1 more source

Membrane microdomain components of Histoplasma capsulatum yeast forms, and their role in alveolar macrophage infectivity.

Biochimica et Biophysica Acta, 2012
Analysis of membrane lipids of Histoplasma capsulatum showed that ~40% of fungal ergosterol is present in membrane microdomain fractions resistant to treatment with non-ionic detergent at 4°C.
Loriane Tagliari, M. Toledo, Tanil G Lacerda, E. Suzuki, A. H. Straus, Hélio K. Takahashi   +5 more
semanticscholar   +1 more source

Bioinspired Polypeptide Dendrimer‐Modified Thin‐Film Composite Membranes for Selective Lithium‐Magnesium Separation with DFT Insights

Advanced Functional Materials, EarlyView.
We fabricated a biomimetic dendrimer‐modified thin‐film nanocomposite membrane with a coordination‐assisted ion‐selective interface. pH‐responsive polypeptide sites preferentially bind Mg2+ and promote Li+ permeation, as predicted by density functional theory calculations of metal‐ligand interactions.
Mehrasa Yassari, Seyedeh Fatemeh Seyedpour, Bamlak Setegne, Amir Aghaei, Behzad Ahvazi, Mostafa Dadashi Firouzjaei, Mark Elliott, Mohtada Sadrzadeh   +7 more
wiley   +1 more source

Membrane Associated RNA‐Containing Vesicles Regulate Cortical Astrocytic Microdomain Calcium Transients in Awake Ischemic Stroke Mice

Advanced Science
Astrocytic processes minutely regulate neuronal activity via tripartite synaptic structures. The precision‐tuning of the function of astrocytic processes is garnering increasing attention because of its significance in promoting brain repair following ...
Zhongqiu Zhou, Ying Bai, Xiaochun Gu, Hui Ren, Wen Xi, Yu Wang, Liang Bian, Xue Liu, Ling Shen, Xianyuan Xiang, Wenhui Huang, Zhuojuan Luo, Bing Han, Honghong Yao   +13 more
doaj   +1 more source

Nernst–Planck–Gaussian finite element modelling of Ca2+ electrodiffusion in amphibian striated muscle transverse tubule–sarcoplasmic reticular triadic junctional domains

Frontiers in Physiology
IntroductionIntracellular Ca2+ signalling regulates membrane permeabilities, enzyme activity, and gene transcription amongst other functions. Large transmembrane Ca2+ electrochemical gradients and low diffusibility between cell compartments potentially ...
Marco D. Rodríguez, Joshua A. Morris, Oliver J. Bardsley, Hugh R. Matthews, Christopher L.-H. Huang, Christopher L.-H. Huang   +5 more
doaj   +1 more source

Microdomain Protein Nce102 Is a Local Sensor of Plasma Membrane Sphingolipid Balance

Microbiology Spectrum, 2022
Sphingolipids are essential building blocks of eukaryotic membranes and important signaling molecules that are regulated tightly in response to environmental and physiological inputs.
Jakub Zahumenský, Caroline Mota Fernandes, Petra Veselá, Maurizio Del Poeta, James B. Konopka, Jan Malínský   +5 more
doaj   +1 more source