Results 121 to 130 of about 29,523 (243)

Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines

Exploration, EarlyView.
This review provides a comprehensive analysis of recent advancements in extracellular vesicle (EV)‐based messenger RNA (mRNA) applications for therapeutics and vaccines. It systematically outlines strategies for mRNA encapsulation within EVs and elucidates the challenges associated with this technology, offering insights into future research directions
Qi Li, Haonan Xing, Abid Naeem, Kaiyue Zhang, Aiping Zheng, Yuanyu Huang, Mei Lu   +6 more
wiley   +1 more source

Membrane microdomains in hepatocytes: potential target areas for proteins involved in canalicular bile secretion

Journal of Lipid Research, 2005
The formation of hepatic bile requires that water be transported across liver epithelia. Rat hepatocytes express three aquaporins (AQPs): AQP8, AQP9, and AQP0. Recognizing that cholesterol and sphingolipids are thought to promote the assembly of proteins
P. Tietz, J. Jefferson, R. Pagano, N.F. LaRusso   +3 more
doaj   +1 more source

Surface Symphony: Orchestrating DPPC/DOPC Monolayer Behavior

Microscopy Research and Technique, EarlyView.
Langmuir trough and atomic force microscopy reveals the physical nature of DPPC and DOPC mixed monolayers. ABSTRACT This study investigates the impact of environmental factors and lipid composition on the structural and morphological properties of DPPC/DOPC (1,2‐Dipalmitoyl‐sn‐glycero‐3‐phosphocholine/1,2‐dioleoyl‐sn‐glycero‐3‐phosphocholine ...
Wisnu Arfian A. Sudjarwo, Jose L. Toca‐Herrera   +1 more
wiley   +1 more source

Rafts defined: a report on the Keystone symposium on lipid rafts and cell function

Journal of Lipid Research, 2006
The recent Keystone Symposium on Lipid Rafts and Cell Function (March 23–28, 2006 in Steamboat Springs, CO) brought together biophysicists, biochemists, and cell biologists to discuss the structure and function of lipid rafts.
Linda J. Pike
doaj   +1 more source

Virus Assembly on a Membrane is Facilitated by Membrane Microdomains

, 2014
For many viruses assembly and budding occur simultaneously during virion formation. Understanding the mechanisms underlying this process could promote biomedical efforts to block viral propagation and enable use of capsids in nanomaterials applications.
Ruiz-Herrero, Teresa, Hagan, Michael F.
openaire   +2 more sources

Mallotus philippensis Extract‐Infused Locust Bean Gum‐Based Ternary Hydrogel: A Green Fabrication Approach for the Controlled Release of Levofloxacin

Macromolecular Bioscience, EarlyView.
A novel bio‐based hydrogel was developed using Mallotus philippensis extract, Lucast bean gum, and chitosan for controlled levofloxacin release. The hydrogel exhibited excellent swelling behavior, antimicrobial activity, and pH‐responsive drug release, demonstrating its potential for advanced wound healing and targeted drug delivery applications ...
Sehrish Jabeen, Atif Islam, Rafi Ullah Khan, Dirk W. Schubert   +3 more
wiley   +1 more source

Partitioning into ER membrane microdomains impacts autophagic protein turnover during cellular aging

Scientific Reports
Eukaryotic membranes are compartmentalized into distinct micro- and nanodomains that rearrange dynamically in response to external and internal cues. This lateral heterogeneity of the lipid bilayer and associated clustering of distinct membrane proteins ...
Simon Prokisch, Sabrina Büttner
doaj   +1 more source

Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity [PDF]

, 2009
L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role in the progression of human carcinoma. Overexpression promotes tumour-cell invasion and motility, growth in nude mice and tumour metastasis.
Altevogt, Peter, Bondong, Sandra, Gast, Daniela, Gutwein, Paul, Kiefel, Helena, Riedle, Svenja, Wolterink, Silke   +6 more
core  

Recent advances in mathematical modeling and statistical analysis of exocytosis in endocrine cells [PDF]

, 2016
open5noMost endocrine cells secrete hormones as a result of Ca(2+)-regulated exocytosis, i.e., fusion of the membranes of hormone-containing secretory granules with the cell membrane, which allows the hormone molecules to escape to the extracellular ...
Cortese, Giuliana, Montefusco, Francesco, Pedersen, Morten Gram, Riz, Michela, Tagliavini, Alessia   +4 more
core   +1 more source

The Dual Role of Exosomes in the Tumor Microenvironment: From Pro‐Tumorigenic Signaling to Immune Modulation

Med Research, EarlyView.
Tumor‐derived exosomes influence proliferation, invasion, angiogenesis, metabolic adaptation, and resistance to therapy. They also shape the immune landscape by modulating antigen presentation, suppressing cytotoxic lymphocyte activity, and promoting the expansion of immunosuppressive cell populations. Although frequently associated with immune evasion,
Jiale Li, Jun Peng, Jiachong Wang, Zigui Chen   +3 more
wiley   +1 more source