Results 161 to 170 of about 29,208 (221)
Toxic mechanisms of amyloid oligomers and therapeutic strategies
Protein Science, Volume 35, Issue 4, April 2026.Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova +2 more
wiley +1 more source
Identification of an amphipathic peptide sensor of the Bacillus subtilis fluid membrane microdomains. [PDF]
Commun Biol, 2019 Jiang Y, Dai X, Qin M, Guo Z.
europepmc +1 more source
Pravastatin Corrects Endothelial Dysfunction in Ex Vivo Uterine Radial Arteries in Preeclampsia
Acta Physiologica, Volume 242, Issue 4, April 2026.ABSTRACT Aim Endothelium‐dependent relaxation in isolated uterine radial arteries from normotensive (NT) and preeclamptic (PE) pregnancies, and the acute effects of pravastatin in the latter vessels were assessed. Pravastatin is hypothesized to alleviate endothelial dysfunction in PE via modulating aspects of NO and endothelium‐derived ...
Nathan M. Luque +11 more
wiley +1 more source
Targeting Cellular Lipid Rafts for Dynamic Nuclear Polarization Nuclear Magnetic Resonance
ChemBioChem, Volume 27, Issue 5, 13 March 2026.Illuminating lipid rafts within intact cells using dynamic nuclear polarization (DNP). Targeting lipid rafts with the protein ostreolysin A allows the selective delivery of DNP‐compatible radicals, generating hyperpolarization of nuclear spins in the lipid raft. Lipid rafts serve as important platforms for membrane and signaling proteins.
Sarah A. Overall +7 more
wiley +1 more source
Laurdan: Clarifying Photophysics and Advancing the Characterization of Extracellular Vesicles
ChemPhysChem, Volume 27, Issue 5, 13 March 2026.Biophysical properties of extracellular vesicles (EVs) reflect their composition and membrane organization. We introduce a novel approach using time‐resolved emission spectra (TRES) phasor analysis of the polarity‐sensitive probe Laurdan to characterize membranes with complex compositions.
Petra Riegerová +8 more
wiley +1 more source
FUNCTIONS OF MICRODOMAINS OF VACUOLAR MEMBRANE [PDF]
Book of proceedings of The Second All-Russian Scientific Conference with international participation "Regulation Mechanisms of Eukariotic Cell Organelle Functions", 2018 I.S. Nesterkina +5 more
openaire +1 more source
Structural and Functional Characterization of EXPO‐Derived Extracellular Vesicles in Plants
Advanced Science, Volume 13, Issue 14, 9 March 2026.In this study, 3D electron tomography (ET), cryo‐ET, and immunogold transmission electron microscopy (TEM) are employed to characterize plant extracellular vesicles (EVs) under physiological conditions. EVs are classified into three distinct categories according to their size, content, and molecular‐marker profiles. Furthermore, Exo70E2‐positive medium
Jiayang Gao +12 more
wiley +1 more source
Advanced Science, Volume 13, Issue 14, 9 March 2026.Inspired by epithelial tissue, epithelium‐like structure hydrogels are synthesized. The as‐prepared hydrogels exhibit ultrahigh toughness, ultralow hysteresis, and ultrahigh compressibility, which can be utilized as self‐powered and visual strain sensors.
Yutang Zhou +4 more
wiley +1 more source
Plant Hormones Differentially Control the Sub-Cellular Localization of Plasma Membrane Microdomains during the Early Stage of Soybean Nodulation. [PDF]
Genes (Basel), 2019 Qiao Z, Zogli P, Libault M.
europepmc +1 more source
Advanced Science, Volume 13, Issue 14, 9 March 2026.A mechanically robust, ROS‐responsive hydrogel is engineered to treat intervertebral disc degeneration by targeting the NF‐κB–LCN2 inflammatory feedback loop. By delivering wedelolactone specifically within oxidative niches, this system disrupts macrophage–disc cell crosstalk.
Zimei Wu +10 more
wiley +1 more source