Results 161 to 170 of about 29,523 (243)

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Phospholipase D2: functional interaction with caveolin in low‐density membrane microdomains [PDF]

, 2000
Malgorzata Czarny, Giusy Fiucci, Yaakov Lavie, Yoshiko Banno, Y. Nozawa, Mordechai Liscovitch   +5 more
openalex   +1 more source

Missense Variants in the Second Transmembrane Domain of TMEM17 Disrupt Its Stability and Function and Lead to a Wide Phenotypic Spectrum of Ciliopathies

Clinical Genetics, EarlyView.
Missense variants in TMEM17 disrupt its localization and function at the ciliary transition zone, leading to a wide range of ciliopathy phenotypes, from OFD6 and Joubert syndromes to Meckel syndrome. ABSTRACT Ciliopathies are rare genetic disorders characterized by significant genetic and phenotypic variability.
Lucile Boutaud, Chunmei Li, Candice Moncler, Laure Verlin, Meriem Garfa‐Traoré, Nicolas Bourgon, Dhruvin Akbari, Jeanne Porée, Valentina Serpieri, Marine Panza, Lynda Haddad, Patrick Nitschké, Jacqueline Aziza, Cristina Matt, Enza Maria Valente, Patricia Gargallo, Charlotte Dubucs, Tania Attié‐Bitach, Michel R. Leroux, Sophie Thomas   +19 more
wiley   +1 more source

Ellagic Acid‐Loaded sEVs Encapsulated in GelMA Hydrogel Accelerate Diabetic Wound Healing by Activating EGFR on Skin Repair Cells

Cell Proliferation, EarlyView.
Ellagic acid (EA) was loaded in small extracellular vehicles (sEVs) derived from chorionic plate‐mesenchymal stem cells (CP‐MSCs) and then encapsulated in GelMA to construct Gel‐EA‐sEVs, which can be a promising treatment approach for diabetic wounds by improving biological functions of skin repair cells.
Lige Tian, Zihao Wang, Shengqiu Chen, Kailu Guo, Yaying Hao, Liqian Ma, Kui Ma, Junli Chen, Xi Liu, Linlin Li, Xiaobing Fu, Cuiping Zhang   +11 more
wiley   +1 more source

Lipid Rafts in Signalling, Diseases, and Infections: What Can Be Learned from Fluorescence Techniques?

Membranes
Lipid rafts are dynamic microdomains in the membrane, rich in cholesterol and sphingolipids, that are critical for biological processes like cell signalling, membrane trafficking, and protein organization.
Sara Anselmo, Elisa Bonaccorso, Chiara Gangemi, Giuseppe Sancataldo, Valeria Conti Nibali, Giovanna D’Angelo   +5 more
doaj   +1 more source

Primary Cilia Orchestrate Cardiac Pathogenesis: A Central Nexus of Remodeling, Signaling, and Repair

Cell Proliferation, EarlyView.
Roles of primary cilia and the signals they transmit in the development of myocardial fibrogenesis, cardiac hypertrophy, and atrial fibrillation. Left, Fibroblasts can differentiate into myofibroblasts in response to TGF‐β1. TGF‐β1 stimulation via both paracrine action in the heart and exogenous action on primary cultured fibroblasts activated the ...
Yang Yang, Kaidi Ren, Xingjuan Shi, Yi Luan   +3 more
wiley   +1 more source

Clostridium difficile Toxins Disrupt Epithelial Barrier Function by Altering Membrane Microdomain Localization of Tight Junction Proteins [PDF]

, 2001
Asma Nusrat, C. von Eichel-Streiber, Jerrold R. Turner, Paul Verkade, James Madara, Charles A. Parkos   +5 more
openalex   +1 more source

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

The FEBS Journal, EarlyView.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman, Valeria Pane, Rania Safadi‐Safa, Meir Solomon, Varda Lev‐Ram, Mohammad Aboraya, Anwar Dakwar, Daniela Bertinetti, Andrew Hoy, Merel O. Mol, John van Swieten, Rodrigo Maillard, Friedrich W. Herberg, Ronit Ilouz   +13 more
wiley   +1 more source

Overlooked aspects of CrRLK1L–RALF signaling

New Phytologist, EarlyView.
Summary Plant development relies on the ability of cells to coordinate growth with the cell wall's biomechanical status. Rapid alkalinization factors (RALFs) and their Catharanthus roseus RLK1‐like (CrRLK1L) kinase receptors form a dynamic signaling system linking wall sensing to growth regulation.
Sébastjen Schoenaers, Kris Vissenberg
wiley   +1 more source

Mapping the transcriptional landscape of algal resistance to viral infection reveals a core expression program

New Phytologist, EarlyView.
Summary Algal blooms and their demise by viruses drive global‐scale ecological processes in the ocean. These blooms form the foundation of marine food webs, regulate microbial communities, and shape biogeochemical cycles. Although algal populations are constantly infected by viruses, resistant subpopulations frequently emerge after the infection.
Talia S. Shaler, Amir Fromm, Daniella Schatz, Shifra Ben‐Dor, Ester Feldmesser, Assaf Vardi   +5 more
wiley   +1 more source