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Isolation of Plasma Membrane and Plasma Membrane Microdomains
2016The plasma membrane surrounds the cytoplasm of a cell and functions as a barrier to separate the intracellular compartment from the extracellular environment. Protein and lipid components distribute nonuniformly and the components form clusters with various functions in the plasma membrane.
Daisuke Takahashi +3 more
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DETECTING MICRODOMAINS IN INTACT CELL MEMBRANES
Annual Review of Physical Chemistry, 2005▪ Abstract Current models for cellular plasma membranes focus on spatial heterogeneity and how this heterogeneity relates to cell function. In particular, putative lipid raft membrane domains have been postulated to exist based in large part on the results that a significant fraction of the membrane is detergent insoluble and that molecules ...
B. Christoffer Lagerholm +3 more
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Membrane microdomains and the regulation of HDL biogenesis
Current Opinion in Lipidology, 2018Purpose of review The major cardio-protective function of HDL is to remove excess cellular cholesterol in the process of HDL particle formation and maturation. The HDL biogenic procedure requiring protein–lipid interactions has been incompletely understood, and here we discuss recent progress and insights into the mechanism of ...
Hong Y. Choi +2 more
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Budded membrane microdomains as tension regulators
Physical Review E, 2006We propose a mechanism by which changes of the mechanical tension of a composite lipid membrane are buffered by the invagination of membrane domains. We show that domain invagination, driven by differences in chemical composition, is a first-order transition controlled by membrane tension.
Pierre Sens +2 more
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Role of the Membrane Skeleton in Creation of Microdomains
2004The membrane skeleton is a specialized part of the cytoskeleton that is in close proximity to the cell membrane with a protein composition and structure that differs from that of the bulk cytoskeleton. The membrane skeleton and various transmembrane proteins bound to it form a mosaic of compartments in the membrane that is responsible for the temporary
Akihiro Kusumi, Ken Ritchie
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T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains
Science, 1999Although dispensable, costimulation through CD28 facilitates activation of naı̈ve T lymphocytes. CD28 engagement led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements.
Viola, A +3 more
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Lipid-Based Membrane Microdomains in T Cell Activation
Current Immunology Reviews, 2005The immune system is able to mount an immune response against antigens present in the body at very low concentrations and, at the same time, to discriminate precisely between an infectious stimulus and a non-infectious one. During T cell activation, this sensitivity and specificity are achieved by mechanisms of sustained interactions with antigen ...
PIZZO, PAOLA, VIOLA A.
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Visualization of PKA activity in plasma membrane microdomains
Mol. BioSyst., 2011Membrane rafts are sphingolipid- and cholesterol-rich microdomains that contain dynamic arrangements of signaling proteins. Notably, various components of the ubiquitous cAMP/Protein Kinase A (PKA) pathway, including β-adrenergic receptors (β-ARs), G proteins, and adenylyl cyclases (ACs), have been shown to localize differentially between membrane ...
Jin Zhang +3 more
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Presence of detergent-resistant microdomains in lysosomal membranes
Biochemical and Biophysical Research Communications, 2002We examined the association of acetyl-CoA:alpha-glucosaminide N-acetyltransferase, a lysosomal enzyme participating in the degradation of heparan sulfate with other components of the lysosomal membrane. We prepared lysosomal membranes from human placenta and treated them with zwitterionic and non-ionic detergents.
Antje Taute +5 more
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Membrane microdomains: lessons from microscopy
Proceedings, annual meeting, Electron Microscopy Society of America, 1995Specialized regions of plasma membranes displaying lateral heterogeneity are the focus of this Symposium. Specialized membrane domains are known for certain cell types such as differentiated epithelial cells where lateral heterogeneity in lipids and proteins exists between the apical and basolateral portions of the plasma membrane.
J.M Oliver, J.M. Robinson
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