Results 241 to 250 of about 56,803 (290)

Anterior-enriched filopodia create the appearance of asymmetric membrane microdomains in polarizing <i>C. elegans</i> zygotes.

J Cell Sci, 2019
Hirani N, Illukkumbura R, Bland T, Mathonnet G, Suhner D, Reymann AC, Goehring NW.   +6 more
europepmc   +1 more source

PREDICTOR: A Non‐Enzymatic Catalytic Cascade Tool for in Situ Visualization of Small Extracellular Vesicle Surface glycoRNAs

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
PREDICTOR, a non‐enzymatic catalytic circuit for imaging trace glycoRNAs on sEVs, reveals that glycoRNAs abundance negatively correlates with tumour malignancy and is functionally important for sEVs uptake by macrophages ABSTRACT Glycosylated RNAs (glycoRNAs) are membrane‐displayed RNA‐glycan conjugates, but quantitative in situ analysis of low ...
Shuang Xie, Ben Niu, Ruijia Deng, Liu Feng, Zuowei Xie, Shuang Zhao, Hongzhao Yang, Meilin Gong, Jing Sheng, Ligai Zhang, Yan Pi, Ningtao Cheng, Ming Chen, Kai Chang   +13 more
wiley   +1 more source

Ultracentrifugation and Ultrafiltration Differentially Alter the Composition and Functionality of the Biomolecular Corona of Extracellular Vesicles

Journal of Extracellular Biology, Volume 5, Issue 4, April 2026.
ABSTRACT While extracellular vesicles (EVs) are increasingly recognized for their diagnostic and therapeutic potential, many unknowns remain. An emerging and important concept in EV biology is the EV biomolecular corona, a dynamic layer of absorbed biomolecules to the EV membrane that influences EV behaviour, cellular uptake, biodistribution and ...
Frederic St‐Denis‐Bissonnette, Hala Halabi, Marybeth Creskey, Melanie Kirkby, Xu Zhang, Dylan Burger, Lisheng Wang, Jessie R. Lavoie   +7 more
wiley   +1 more source

The importance of membrane microdomains for bile salt-dependent biliary lipid secretion.

J Cell Sci, 2018
Eckstein J, Holzhütter HG, Berndt N.
europepmc   +1 more source

Liquid–Liquid Phase Separation in Viral Infection and Immunology

MedComm, Volume 7, Issue 4, April 2026.
LLPS organizes viral replication and antiviral immunity. Viruses hijack LLPS to form replication factories and evade immune sensors, while hosts assemble LLPS‐driven signaling hubs (e.g., MAVS, RIG‐I, and SGs) to amplify interferon responses. Targeting these condensate interfaces offers novel therapeutic strategies against infectious diseases ...
Jiuzhi Xu, Lan Bai, Bin Wang, Hai Song, Long Zhang, Fangfang Zhou   +5 more
wiley   +1 more source

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 4, April 2026.
The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song, Lin Yuan, Weiguo Yang, Wen Li, Jia‐Yi Li   +4 more
wiley   +1 more source

Toxic mechanisms of amyloid oligomers and therapeutic strategies

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

Pharmacological Separation of Mechanosensory Mechanisms in Rat Urinary Bladder Ex Vivo

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT The local response of the bladder wall to stretch is believed to result from the coordinated activation of mechanosensitive ion channels located in the plasma membrane of the cells that form the wall's urothelial and detrusor smooth muscle (DSM) layers.
Igor B. Philyppov, Ganna V. Sotkis, Semen I. Yelyashov, Valeri G. Naidenov, Yaroslav M. Shuba   +4 more
wiley   +1 more source

DNA Origami Assembly Inside Liposomes via Nanopore‐Mediated DNA Transportation

Small Structures, Volume 7, Issue 4, April 2026.
DNA origami assembly inside giant unilamellar vesicles (GUVs) using externally supplied staple strands is demonstrated. Scaffold DNA is pre‐encapsulated inside GUVs, and staple strands are transported via a pore‐forming membrane protein. Subsequent addition of CaCl2 closes the pores.
Shoji Iwabuchi, Kengo Kurematsu, Kazuya Yokoo, Yusuke Sakai, Yoshihiro Shimizu, Ryuji Kawano   +5 more
wiley   +1 more source

Engineering Yeast Extracellular Vesicle Biogenesis Through Rewiring Membrane Trafficking Pathways

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
Engineered Saccharomyces cerevisiae reveals how cell wall remodelling and membrane trafficking coordinate extracellular vesicle biogenesis. Interferon overexpression and chs3 deletion enhance EV secretion and reshape SNARE‐, Rab‐ and ESCRT‐associated pathways, establishing yeast as a versatile platform for EV engineering and therapeutic cargo loading ...
Yueyan Li, XiaoRan Ma, Lichao Zhang, Ning Cao, Zhibo Li, Ruixin Khoo, Mei Wang, Changyan Li, Deping Hua, Xintian Zheng, Jinhai Huang, Lilin Zhang   +11 more
wiley   +1 more source