Correction: Membrane microdomains and cytoskeleton organization shape and regulate the IL-7 receptor signalosome in human CD4 T-cells. [PDF]
J Biol Chem, 2019 Tamarit B +8 more
europepmc +1 more source
Redox signals and oxidative stress in the control of mitochondrial protein import
Protein Science, Volume 35, Issue 7, July 2026.Abstract Mitochondrial protein import is essential for organelle biogenesis and cellular homeostasis. It operates in an environment that is intrinsically shaped by redox chemistry. Mitochondria are major sources of reactive oxygen species (ROS), which arise as by‐products of oxidative phosphorylation. Cells therefore maintain sophisticated ROS‐handling
Lidwina Hasberg +3 more
wiley +1 more source
Unraveling the role of membrane microdomains during microbial infections. [PDF]
Cell Biol Toxicol, 2017 Bagam P, Singh DP, Inda ME, Batra S.
europepmc +1 more source
Defining AV2‐1 as a novel pharmacological probe to target human and rodent TRPV2
British Journal of Pharmacology, Volume 183, Issue 13, Page 3538-3557, July 2026.Abstract Background and Purpose Transient receptor potential vanilloid 2 (TRPV2) is a non‐selective cation channel implicated in immune cell functions. However, progress in understanding TRPV2 has been limited by a lack of potent and selective pharmacological tools, particularly those targeting the human variant. We aimed to identify and characterise a
Andrea Leipe +6 more
wiley +1 more source
HaloTag Fusion Enables Dynamic Analysis of Prion Protein Biosynthesis, Turnover, and Misfolding
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Prion protein (PrP) misfolding underlies fatal neurodegenerative diseases. We developed a HaloTag‐based PrP fusion enabling spatiotemporal labeling of distinct PrP populations in living cells. This system recapitulates native PrP biology, reveals early misfolding events in disease‐associated mutants, and allows mechanistic interrogation of PrP‐lowering
Antonio Masone +2 more
wiley +1 more source
A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley +1 more source
Matrix Rigidity-Dependent Regulation of Ca2+ at Plasma Membrane Microdomains by FAK Visualized by Fluorescence Resonance Energy Transfer. [PDF]
Adv Sci (Weinh), 2019 Kim TJ +8 more
europepmc +1 more source
Bioconjugation Strategies for Revealing the Roles of Glycerophospholipids in Cells
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Glycerophospholipids are the main class of phospholipids, essential for membrane structure, compartmentalization, and cellular signaling. To study their roles, innovative probes and advanced bioconjugation strategies have been developed, including by de novo lipid synthesis and bioorthogonal conjugation chemistry.
Brice Beauvais +5 more
wiley +1 more source