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Microdomains of SNARE Proteins in the Plasma Membrane
2013Exocytosis is catalyzed by the engagement of SNARE proteins embedded in the plasma membrane with complementary SNAREs in the membrane of trafficking vesicles undergoing exocytosis. In most cells studied so far, SNAREs are not randomly distributed across the plasma membrane but are clustered and segregated in discrete membrane domains of defined size ...
van den Bogaart, G., Lang, T., Jahn, R.
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Functional imaging of microdomains in cell membranes
European Biophysics Journal, 2008The presence of microdomains or rafts within cell membranes is a topic of intense study and debate. The role of these structures in cell physiology, however, is also not yet fully understood with many outstanding problems. This problem is partly based on the small size of raft structures that presents significant problems to their in vivo study, i.e ...
Duggan, James +8 more
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Role of the Membrane Skeleton in Creation of Microdomains
2004The membrane skeleton is a specialized part of the cytoskeleton that is in close proximity to the cell membrane with a protein composition and structure that differs from that of the bulk cytoskeleton. The membrane skeleton and various transmembrane proteins bound to it form a mosaic of compartments in the membrane that is responsible for the temporary
Ken, Ritchie, Akihiro, Kusumi
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PROTEOMICS, 2006
AbstractBiological membranes are compartmentalized into microdomains that exhibit particular lipid and protein compositions. Membrane microdomains, such as tetraspanin‐enriched microdomains and lipid rafts, have been suggested to play a role in a variety of physiological and pathological processes.
François, Le Naour +3 more
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AbstractBiological membranes are compartmentalized into microdomains that exhibit particular lipid and protein compositions. Membrane microdomains, such as tetraspanin‐enriched microdomains and lipid rafts, have been suggested to play a role in a variety of physiological and pathological processes.
François, Le Naour +3 more
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Molecular principles of membrane microdomain targeting in plants
Trends in Plant Science, 2015Plasma membranes (PMs) are heterogeneous lipid bilayers comprising diverse subdomains. These sites can be labeled by various proteins in vivo and may serve as hotspots for signal transduction. They are found at apical, basal, and lateral membranes of polarized cells, at cell equatorial planes, or almost isotropically distributed throughout the PM ...
Konrad, Sebastian S. A., Ott, Thomas
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Membrane raft microdomains in chemokine receptor function
Seminars in Immunology, 2001Cell chemotaxis requires the acquisition and maintenance of both spatial and functional asymmetry between initially equivalent cell parts. In leukocytes one becomes the leading edge and the other, the rear edge or uropod. The acquisition of this cell polarity is controlled by an array of chemoattractants, including those of the chemokine family.
S, Mañes +5 more
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Lipid microdomains – plant membranes get organized
Trends in Plant Science, 2005The plant plasma membrane is now known to be a more sophisticated structure than was previously thought. Sebastien Mongrand et al. and Georg Borner et al. have isolated specific plasma membrane microdomains ('lipid rafts') that are enriched in sterols and sphingolipids.
Stephen W, Martin +2 more
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Visualization of PKA activity in plasma membrane microdomains
Molecular BioSystems, 2010Abstract Membrane rafts are sphingolipid- and cholesterol-rich microdomains that contain dynamic arrangements of signalingproteins. Notably, various components of the ubiquitous cAMP/Protein Kinase A (PKA) pathway, including β-adrenergic receptors (β-ARs), G proteins, and adenylyl cyclases (ACs), have been shown to localize ...
Charlene, Depry +2 more
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The amplification of TCR signaling by dynamic membrane microdomains
Trends in Immunology, 2001Modulation of T-cell receptor (TCR) signaling is essential for the regulation of T-cell responses to infectious agents. Recently, many laboratories have suggested that TCR triggering might be compartmentalized in plasma membrane microdomains called rafts.
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