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Membrane microdomains: Structural and signaling platforms for establishing membrane polarity

Plant Physiology, 2023
AbstractCell polarity results from the asymmetric distribution of cellular structures, molecules, and functions. Polarity is a fundamental cellular trait that can determine the orientation of cell division, the formation of particular cell shapes, and ultimately the development of a multicellular body.
Ruili Li   +4 more
openaire   +2 more sources

Membrane microdomains: lessons from microscopy

Proceedings, annual meeting, Electron Microscopy Society of America, 1995
Specialized regions of plasma membranes displaying lateral heterogeneity are the focus of this Symposium. Specialized membrane domains are known for certain cell types such as differentiated epithelial cells where lateral heterogeneity in lipids and proteins exists between the apical and basolateral portions of the plasma membrane.
J.M. Robinson, J.M Oliver
openaire   +1 more source

Isolation of Plasma Membrane and Plasma Membrane Microdomains

2016
The plasma membrane surrounds the cytoplasm of a cell and functions as a barrier to separate the intracellular compartment from the extracellular environment. Protein and lipid components distribute nonuniformly and the components form clusters with various functions in the plasma membrane.
Anzu, Minami   +3 more
openaire   +2 more sources

Membrane raft microdomains in chemokine receptor function

Seminars in Immunology, 2001
Cell chemotaxis requires the acquisition and maintenance of both spatial and functional asymmetry between initially equivalent cell parts. In leukocytes one becomes the leading edge and the other, the rear edge or uropod. The acquisition of this cell polarity is controlled by an array of chemoattractants, including those of the chemokine family.
S, Mañes   +5 more
openaire   +2 more sources

Functional imaging of microdomains in cell membranes

European Biophysics Journal, 2008
The presence of microdomains or rafts within cell membranes is a topic of intense study and debate. The role of these structures in cell physiology, however, is also not yet fully understood with many outstanding problems. This problem is partly based on the small size of raft structures that presents significant problems to their in vivo study, i.e ...
Duggan, James   +8 more
openaire   +2 more sources

White Matter Rafting––Membrane Microdomains in Myelin

Neurochemical Research, 2006
The myelin membrane comprises a plethora of regions that are compositionally, ultrastructurally, and functionally distinct. Biochemical dissection of oligodendrocytes, Schwann cells, and central and peripheral nervous system myelin by means such as cold-detergent extraction and differential fractionation has led to the identification of a variety of ...
Lillian S, Debruin, George, Harauz
openaire   +2 more sources

Visualization of PKA activity in plasma membrane microdomains

Mol. BioSyst., 2011
Membrane rafts are sphingolipid- and cholesterol-rich microdomains that contain dynamic arrangements of signaling proteins. Notably, various components of the ubiquitous cAMP/Protein Kinase A (PKA) pathway, including β-adrenergic receptors (β-ARs), G proteins, and adenylyl cyclases (ACs), have been shown to localize differentially between membrane ...
Charlene, Depry   +2 more
openaire   +2 more sources

Microdomains of SNARE Proteins in the Plasma Membrane

2013
Exocytosis is catalyzed by the engagement of SNARE proteins embedded in the plasma membrane with complementary SNAREs in the membrane of trafficking vesicles undergoing exocytosis. In most cells studied so far, SNAREs are not randomly distributed across the plasma membrane but are clustered and segregated in discrete membrane domains of defined size ...
van den Bogaart, G., Lang, T., Jahn, R.
openaire   +5 more sources

Presence of detergent-resistant microdomains in lysosomal membranes

Biochemical and Biophysical Research Communications, 2002
We examined the association of acetyl-CoA:alpha-glucosaminide N-acetyltransferase, a lysosomal enzyme participating in the degradation of heparan sulfate with other components of the lysosomal membrane. We prepared lysosomal membranes from human placenta and treated them with zwitterionic and non-ionic detergents.
Antje, Taute   +5 more
openaire   +2 more sources

Syndecans: proteoglycan regulators of cell-surface microdomains?

Nature Reviews Molecular Cell Biology, 2003
John R Couchman
exaly  

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