Results 61 to 70 of about 29,208 (221)

Lck, membrane microdomains and TCR triggering machinery: defining the new rules of engagement

Frontiers in Immunology, 2012
In spite of a comprehensive understanding of the schematics of T cell receptor (TCR) signaling, the mechanisms regulating compartmentalization of signaling molecules, their transient interactions and rearrangement of membrane structures initiated upon ...
Dominik eFilipp, Ondřej eBallek, Jasper eManning   +2 more
doaj   +1 more source

Rethinking Extracellular Vesicle Signaling

Advanced Materials, EarlyView.
Extracellular vesicles enable cell communication beyond intracellular cargo delivery. This perspective highlights two plausible surface‐based signaling modes: “bind‐and‐stay” and “bind‐and‐leave.” Transient binding to multiple cells challenges the one‐vesicle‐one‐cell model.
Wojciech Chrzanowski, Joy Wolfram
wiley   +1 more source

A novel biotinylated lipid raft reporter for electron microscopic imaging of plasma membrane microdomains

Journal of Lipid Research, 2012
The submicroscopic spatial organization of cell surface receptors and plasma membrane signaling molecules is readily characterized by electron microscopy (EM) via immunogold labeling of plasma membrane sheets.
Kimberly J. Krager, Mitul Sarkar, Erik C. Twait, Nancy L. Lill, John G. Koland   +4 more
doaj   +1 more source

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

Human Immunodeficiency Virus Type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains

Retrovirology, 2007
Background The Nef protein of Human Immunodeficiency Viruses optimizes viral spread in the infected host by manipulating cellular transport and signal transduction machineries.
Geyer Matthias, Breuer Sebastian, Glass Bärbel, Leibrecht Iris, Rauch Susanne, Munte Claudia E, Tibroni Nadine, Krautkrämer Ellen, Brügger Britta, Kräusslich Hans-Georg, Kalbitzer Hans, Wieland Felix T, Fackler Oliver T   +12 more
doaj   +1 more source

Raft microdomain localized in the luminal leaflet of inner membrane complex of living Toxoplasma gondii

European Journal of Cell Biology, 2021
Membrane microdomains or rafts, sterol- and sphingolipid-rich microdomains in the plasma membrane have been studied extensively in mammalian cells. Recently, rafts were found to mediate virulence in a variety of parasites, including Toxoplasma gondii ...
Rikako Konishi, Yuna Kurokawa, Kanna Tomioku, Tatsunori Masatani, Xuenan Xuan, Akikazu Fujita   +5 more
doaj   +1 more source

Lipid microdomains in cell surface membranes

Current Opinion in Structural Biology, 1997
Lipid microdomains within cell membranes are detected by a variety of experimental techniques, each of which characterizes microdomains on a different time and spatial scale. The sum of the data on lipid microdomains has yet to be integrated into a single model of cell membrane structure.
openaire   +2 more sources

Super‐Enhancer‐Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression

Advanced Science, EarlyView.
Chronic myeloid leukemia blast phase (CML‐BP) poses a severe therapeutic challenge. This study reveals that the super‐enhancer‐driven transcription factors SOX4 and SMAD3 form a cooperative axis critical for disease progression. They co‐activate the oncogenic kinase AXL and promote phospholipid remodeling via LPCAT1 to facilitate its signaling ...
Enzhe Lou, Peilong Lai, Guanjie Peng, Bo Lu, Lizhen Jiang, Xinyue Li, Jinghong Chen, Ladi Mo, Qiong Mao, Haichuan Zhang, Jinxin Fang, Yi Meng, Aochu Liu, Yingyin Gao, Andong Huang, Wenhui Lin, Shiwen Hu, Zerong Guan, Xiaolan Ye, Zhenguo Liu, Liling Jiang, Yueyuan Zheng, Xianping Shi   +22 more
wiley   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Receptor Tyrosine Kinases — Expanding Horizons

Cells, 2014
This Special Issue of Cells on receptor tyrosine kinases (RTKs) is a timely and unique assemblage of scholarly insights into topics that have relatively recently entered the spotlight in relation to this class of molecules. The review by Julien et al. [1]
Sassan Hafizi
doaj   +1 more source