Results 21 to 30 of about 9,896,950 (388)

Cholesterol-Recognition Motifs in Membrane Proteins.

Advances in Experimental Medicine and Biology, 2019
The impact of cholesterol on the structure and function of membrane proteins was recognized several decades ago, but the molecular mechanisms underlying these effects have remained elusive.
J. Fantini, R. Epand, F. Barrantes
semanticscholar   +1 more source

Lipid–Protein Interactions Are Unique Fingerprints for Membrane Proteins

bioRxiv, 2017
Cell membranes contain hundreds of different proteins and lipids in an asymmetric arrangement. Understanding the lateral organization principles of these complex mixtures is essential for life and health.
V. Corradi, E. Mendez-Villuendas, H. Ingólfsson, Ruo-Xu Gu, Iwona Siuda, Manuel N. Melo, Anastassiia Moussatova, Lucien J. DeGagné, Besian I Sejdiu, Gurpreet Singh, T. Wassenaar, Karelia Delgado Magnero, S. Marrink, D. Tieleman   +13 more
semanticscholar   +1 more source

Evaluation of four different strategies to characterize plasma membrane proteins from banana roots [PDF]

, 2015
Plasma membrane proteins constitute a very important class of proteins. They are involved in the transmission of external signals to the interior of the cell and selective transport of water, nutrients and ions across the plasma membrane.
Carpentier, Sebastien C., García, S., Panis, B., Swennen, Rony L.   +3 more
core   +1 more source

Extragenic Suppression analysis of TS mutations using Sec61p [PDF]

, 2007
During synthesis, secretory and membrane proteins are cotranslationally translocated into the lumen of the endoplasmic reticulum through an aqueous gated channel.
Sterling Smith
core   +2 more sources

Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors [PDF]

, 2020
Detergents enable the purification of membrane proteins and are indispensable reagents instructural biology. Even though a large variety of detergents have been developed in the lastcentury, the challenge remains to identify guidelines that allowfine ...
Almeida, F., Bolla, J., Ehrmann, S., Gault, J., Haag, R., Hoi, K., Liko, I., Pagel, K., Robinson, C., Schweder, M., Shutin, D., Urner, L., Yen, H.   +12 more
core   +2 more sources

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

eLife, 2023
Allosteric modulation of G protein-coupled receptors (GPCRs) is a major paradigm in drug discovery. Despite decades of research, a molecular-level understanding of the general principles that govern the myriad pharmacological effects exerted by GPCR ...
Ziva Vuckovic, Jinan Wang, Vi Pham, Jesse I Mobbs, Matthew J Belousoff, Apurba Bhattarai, Wessel AC Burger, Geoff Thompson, Mahmuda Yeasmin, Vindhya Nawaratne, Katie Leach, Emma T van der Westhuizen, Elham Khajehali, Yi-Lynn Liang, Alisa Glukhova, Denise Wootten, Craig W Lindsley, Andrew Tobin, Patrick Sexton, Radostin Danev, Celine Valant, Yinglong Miao, Arthur Christopoulos, David M Thal   +23 more
doaj   +1 more source

NMR studies of membrane structure and dynamics [PDF]

, 1978
Over the past decade, there has been considerable interest in the motional state of the phospholipid bilayer membrane. The motivation underlying these efforts has been the contention that the phospholipid bilayer is the basic matrix in which membrane ...
Bocian, David F., Chan, Sunney I.
core   +1 more source

Fluorescently tagged nanobodies and NanoBRET to study ligand-binding and agonist-induced conformational changes of full-length EGFR expressed in living cells

Frontiers in Immunology, 2022
IntroductionThe Epidermal Growth Factor Receptor is a member of the Erb receptor tyrosine kinase family. It binds several ligands including EGF, betacellulin (BTC) and TGF-α, controls cellular proliferation and invasion and is overexpressed in various ...
Dehan Comez, Dehan Comez, Jacqueline Glenn, Jacqueline Glenn, Stephanie M. Anbuhl, Stephanie M. Anbuhl, Raimond Heukers, Raimond Heukers, Martine J. Smit, Stephen J. Hill, Stephen J. Hill, Laura E. Kilpatrick, Laura E. Kilpatrick   +12 more
doaj   +1 more source

Detergents and Chaotropes for Protein Solubilization before Two-Dimensional Electrophoresis [PDF]

, 2006
Because of the outstanding separating capabilities of two-dimensional electrophoresis for complete proteins, it would be advantageous to be able to apply it to all types of proteins.
Chevallet, Mireille, Luche, Sylvie, Rabilloud, Thierry, Santoni, Véronique   +3 more
core   +4 more sources

Sterol transporters at membrane contact sites regulate TORC1 and TORC2 signaling. [PDF]

, 2017
Membrane contact sites (MCSs) function to facilitate the formation of membrane domains composed of specialized lipids, proteins, and nucleic acids. In cells, membrane domains regulate membrane dynamics and biochemical and signaling pathways.
Murley, Andrew, Niles, Bradley J, Nunnari, Jodi, Powers, Ted, Prinz, William A, Toulmay, Alexandre, Yamada, Justin   +6 more
core   +1 more source