Results 21 to 30 of about 8,472,722 (389)
In vitro reconstitution of substrate S-acylation by the zDHHC family of protein acyltransferases
Open Biology, 2022 Protein S-acylation, more commonly known as protein palmitoylation, is a biological process defined by the covalent attachment of long chain fatty acids onto cysteine residues of a protein, effectively altering the local hydrophobicity and influencing ...
R. Elliot Murphy, Anirban Banerjee
doaj +1 more source
Membrane shape deformation induced by curvature-inducing proteins consisting of chiral crescent binding and intrinsically disordered domains [PDF]
J. Chem. Phys. 157, 034901 (2022), 2022 Curvature-inducing proteins containing a Bin/Amphiphysin/Rvs domain often have intrinsically disordered domains. Recent experiments have shown that these disordered chains enhance curvature sensing and generation. Here, we report on the modification of protein-membrane interactions by disordered chains using meshless membrane simulations.
arxiv +1 more source
Binding of anisotropic curvature-inducing proteins onto membrane tubes [PDF]
Soft Matter 18, 3384-3394 (2022), 2022 Bin/Amphiphysin/Rvs superfamily proteins and other curvature-inducing proteins have anisotropic shapes and anisotropically bend biomembrane. Here, we report how the anisotropic proteins bind the membrane tube and are orientationally ordered using mean-field theory including an orientation-dependent excluded volume.
arxiv +1 more source
EMBO Journal, 2018 Proteolytic removal of membrane protein ectodomains (ectodomain shedding) is a post‐translational modification that controls levels and function of hundreds of membrane proteins.
S. Lichtenthaler +2 more
semanticscholar +1 more source
eLife, 2023 Allosteric modulation of G protein-coupled receptors (GPCRs) is a major paradigm in drug discovery. Despite decades of research, a molecular-level understanding of the general principles that govern the myriad pharmacological effects exerted by GPCR ...
Ziva Vuckovic +23 more
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The mystery of membrane organization: composition, regulation and roles of lipid rafts
Nature Reviews Molecular Cell Biology, 2017 Erdinc Sezgin +2 more
exaly +2 more sources
Kinetics and Thermodynamics of Membrane Protein Folding [PDF]
Biomolecules 2014, 4(1), 354-373, 2014 Understanding protein folding has been one of the great challenges in biochemistry and molecular biophysics. Over the past 50 years, many thermodynamic and kinetic studies have been performed addressing the stability of globular proteins. In comparison, advances in the membrane protein folding field lag far behind. Although membrane proteins constitute
arxiv +1 more source
Frontiers in Immunology, 2022 IntroductionThe Epidermal Growth Factor Receptor is a member of the Erb receptor tyrosine kinase family. It binds several ligands including EGF, betacellulin (BTC) and TGF-α, controls cellular proliferation and invasion and is overexpressed in various ...
Dehan Comez +12 more
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Lipid–Protein Interactions Are Unique Fingerprints for Membrane Proteins
bioRxiv, 2017 Cell membranes contain hundreds of different proteins and lipids in an asymmetric arrangement. Understanding the lateral organization principles of these complex mixtures is essential for life and health.
V. Corradi +13 more
semanticscholar +1 more source
Bilayer-thickness-mediated interactions between integral membrane proteins [PDF]
Phys. Rev. E 93, 042410 (2016), 2016 Hydrophobic thickness mismatch between integral membrane proteins and the surrounding lipid bilayer can produce lipid bilayer thickness deformations. Experiment and theory have shown that protein-induced lipid bilayer thickness deformations can yield energetically favorable bilayer-mediated interactions between integral membrane proteins, and large ...
arxiv +1 more source