Results 21 to 30 of about 2,550,973 (230)

Physical limits to membrane curvature sensing by a single protein [PDF]

open access: yesPhys. Rev. E 108, 064407 (2023), 2022
Membrane curvature sensing is essential for a diverse range of biological processes. Recent experiments have revealed that a single nanometer-sized septin protein can distinguish between membrane-coated glass beads of one micron and three micron diameters, even though the septin is orders of magnitude smaller than the beads.
arxiv   +1 more source

Development of a membrane-based Gi-CASE biosensor assay for profiling compounds at cannabinoid receptors

open access: yesFrontiers in Pharmacology, 2023
Introduction: The cannabinoid receptor (CBR) subtypes 1 (CB1R) and 2 (CB2R) are key components of the endocannabinoid system (ECS), playing a central role in the control of peripheral pain, inflammation and the immune response, with further roles in the ...
Morgan Scott-Dennis   +18 more
doaj   +1 more source

Super-Resolution Imaging Approaches for Quantifying F-Actin in Immune Cells

open access: yesFrontiers in Cell and Developmental Biology, 2021
Immune cells comprise a diverse set of cells that undergo a complex array of biological processes that must be tightly regulated. A key component of cellular machinery that achieves this is the cytoskeleton.
Evelyn Garlick   +5 more
doaj   +1 more source

In vitro reconstitution of substrate S-acylation by the zDHHC family of protein acyltransferases

open access: yesOpen Biology, 2022
Protein S-acylation, more commonly known as protein palmitoylation, is a biological process defined by the covalent attachment of long chain fatty acids onto cysteine residues of a protein, effectively altering the local hydrophobicity and influencing ...
R. Elliot Murphy, Anirban Banerjee
doaj   +1 more source

Membrane shape deformation induced by curvature-inducing proteins consisting of chiral crescent binding and intrinsically disordered domains [PDF]

open access: yesJ. Chem. Phys. 157, 034901 (2022), 2022
Curvature-inducing proteins containing a Bin/Amphiphysin/Rvs domain often have intrinsically disordered domains. Recent experiments have shown that these disordered chains enhance curvature sensing and generation. Here, we report on the modification of protein-membrane interactions by disordered chains using meshless membrane simulations.
arxiv   +1 more source

Rampant exchange of the structure and function of extramembrane domains between membrane and water soluble proteins. [PDF]

open access: yes, 2013
Of the membrane proteins of known structure, we found that a remarkable 67% of the water soluble domains are structurally similar to water soluble proteins of known structure. Moreover, 41% of known water soluble protein structures share a domain with an
Bowie, James U   +3 more
core   +3 more sources

Binding of anisotropic curvature-inducing proteins onto membrane tubes [PDF]

open access: yesSoft Matter 18, 3384-3394 (2022), 2022
Bin/Amphiphysin/Rvs superfamily proteins and other curvature-inducing proteins have anisotropic shapes and anisotropically bend biomembrane. Here, we report how the anisotropic proteins bind the membrane tube and are orientationally ordered using mean-field theory including an orientation-dependent excluded volume.
arxiv   +1 more source

The Bacterial Photosynthetic Reaction Center as a Model for Membrane Proteins [PDF]

open access: yes, 1989
Membrane proteins participate in many fundamental cellular processes. Until recently, an understanding of the function and properties of membrane proteins was hampered by an absence of structural information at the atomic level.
Allen, J. P.   +4 more
core   +1 more source

Evaluation of four different strategies to characterize plasma membrane proteins from banana roots [PDF]

open access: yes, 2015
Plasma membrane proteins constitute a very important class of proteins. They are involved in the transmission of external signals to the interior of the cell and selective transport of water, nutrients and ions across the plasma membrane.
Carpentier, Sebastien C.   +3 more
core   +1 more source

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

open access: yeseLife, 2023
Allosteric modulation of G protein-coupled receptors (GPCRs) is a major paradigm in drug discovery. Despite decades of research, a molecular-level understanding of the general principles that govern the myriad pharmacological effects exerted by GPCR ...
Ziva Vuckovic   +23 more
doaj   +1 more source

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