Polyene antibiotic that inhibits membrane transport proteins. [PDF]
Proc Natl Acad Sci U S A, 2012 The limited therapeutic arsenal and the increase in reports of fungal resistance to multiple antifungal agents have made fungal infections a major therapeutic challenge. The polyene antibiotics are the only group of antifungal antibiotics that directly target the plasma membrane via a specific interaction with the main fungal sterol, ergosterol, often ...
te Welscher YM +4 more
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Membrane transport proteins of the malaria parasite [PDF]
Molecular Microbiology, 2009 SummaryThe malaria parasite‐infected erythrocyte is a multi‐compartment structure, incorporating numerous different membrane systems. The movement of nutrients, metabolites and inorganic ions into and out of the intraerythrocytic parasite, as well as between subcellular compartments within the parasite, is mediated by transporters and channels ...
Hagai Ginsburg +3 more
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Activity assay of membrane transport proteins [PDF]
Acta Biochimica et Biophysica Sinica, 2008 Membrane transport proteins are integral membrane proteins and considered as potential drug targets. Activity assay of transport proteins is essential for developing drugs to target these proteins. Major issues related to activity assessment of transport proteins include availability of transporters, transport activity of transporters, and interactions
Hao Xie
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Exploring the Therapeutic Potential of Membrane Transport Proteins: Focus on Cancer and Chemoresistance. [PDF]
Cancers (Basel), 2020 Improving the therapeutic efficacy of conventional anticancer drugs represents the best hope for cancer treatment. However, the shortage of druggable targets and the increasing development of anticancer drug resistance remain significant problems ...
Almasi S, El Hiani Y.
europepmc +2 more sources
Microbial membrane transport proteins and their biotechnological applications. [PDF]
World J Microbiol BiotechnolBecause of the hydrophobic nature of the membrane lipid bilayer, the majority of the hydrophilic solutes require special transportation mechanisms for passing through the cell membrane.
Özkan M +4 more
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Phylogenetic profiles of all membrane transport proteins of the malaria parasite highlight new drug targets [PDF]
Microb Cell, 2016 In order to combat the on-going malaria epidemic, discovery of new drug targets remains vital. Proteins that are essential to survival and specific to malaria parasites are key candidates.
Weiner J, Kooij TW.
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SCMMTP: identifying and characterizing membrane transport proteins using propensity scores of dipeptides. [PDF]
BMC Genomics, 2015 BackgroundIdentifying putative membrane transport proteins (MTPs) and understanding the transport mechanisms involved remain important challenges for the advancement of structural and functional genomics.
Liou YF +8 more
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Prediction of membrane transport proteins and their substrate specificities using primary sequence information. [PDF]
PLoS One, 2014 Background Membrane transport proteins (transporters) move hydrophilic substrates across hydrophobic membranes and play vital roles in most cellular functions.
Mishra NK, Chang J, Zhao PX.
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Identification and analysis of cDNA clones encoding CD53. A pan-leukocyte antigen related to membrane transport proteins. [PDF]
Journal of Immunology, 1990 CD53 is a human cell-surface Ag expressed exclusively by nucleated cells of hemopoietic origin. In this work a cDNA clone encoding the CD53 Ag was isolated from a COS cell-expression library.
Martine Amiot
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Peroxisomal Metabolite and Cofactor Transport in Humans
Frontiers in Cell and Developmental Biology, 2021 Peroxisomes are membrane-bound organelles involved in many metabolic pathways and essential for human health. They harbor a large number of enzymes involved in the different pathways, thus requiring transport of substrates, products and cofactors ...
Serhii Chornyi +4 more
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