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Membranous nephropathy is a glomerulopathy, which main affected target is the podocyte, and has consequences on the glomerular basement membrane. It is more common in adults, especially over 50 years of age.
Márcio Dantas +5 more
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Rituximab in Membranous Nephropathy [PDF]
Membranous nephropathy (MN) is the most common cause of primary nephrotic syndrome among adults. The identification of phospholipase A2 receptor (PLA2R) as target antigen in most patients changed the management of MN dramatically, and provided a rationale for B-cell depleting agents such as rituximab. The efficacy of rituximab in inducing remission has
Philipp Gauckler +77 more
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Advances in Membranous Nephropathy [PDF]
Membranous nephropathy (MN) is a rare auto-immune disease where the glomerulus is targeted by circulating auto-antibodies mostly against podocyte antigens, which results in the formation of electron-dense immune complexes, activation of complement and massive proteinuria.
Ronco, Pierre +2 more
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Simon C Satchell, Peter W Mathieson
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Treatment of membranous nephropathy [PDF]
Several therapeutic approaches have been tried in patients with membranous nephropathy. Corticosteroids have been largely used, but a meta-analysis of the available controlled trials did not show any benefit of corticosteroids either in favouring remission of the nephrotic syndrome or in preventing renal dysfunction.
Passerini Patrizia, Ponticelli Claudio
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IMMUNODIAGNOSIS IN MEMBRANOUS NEPHROPATHY
One of the diseases leading to chronic end-stage renal disease is membranous nephropathy (MN). The main cause of this disease is the formation of antibodies to foreign and native antigens. Membranous nephropathy can be conventionally divided into 2 types: primary form (when the primary disease is unknown) and secondary form.
Magdalena, Ratajczak +2 more
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Lupus Membranous Nephropathy [PDF]
<b><i>Background:</i></b> Lupus membranous nephropathy (LMN) is a rare disease, usually associated with nephrotic syndrome. <b><i>Methods:</i></b> We reviewed the literature by searching for the following terms on Pubmed.gov: lupus nephritis, membranous nephropathy (MN), lupus membranous nephropathy ...
Ponticelli, Claudio +2 more
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Hyperlipidemia in membranous nephropathy. [PDF]
ABSTRACT Membranous nephropathy (MN) is a common glomerular disease leading to nephrotic syndrome in adults, clinically characterized by massive proteinuria, hypoalbuminemia, and prominent hyperlipidemia. Growing evidence suggests that hyperlipidemia is not merely a secondary consequence of MN, but may also play a critical role in the
Zhang M, Liu WL, Xu G, Dong L.
europepmc +4 more sources
Immunology of membranous nephropathy [PDF]
Accounting for about 20 to 50% of cases of primary nephrotic syndrome, membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults. A rat model created nearly 60 years ago to research the primary MN disorder, Heymann nephritis, has provided us with a plethora of important information.
Shin'ichi Akiyama +2 more
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The Mayo Clinic consensus report on membranous nephropathy; a promising step toward better treating the disease [PDF]
Membranous nephropathy is an immune complex disease caused by subepithelial deposits. The pathological manifestations of membranous nephropathy are considered by the creation of immune complexes in the epithelial cells of the glomerular basement membrane.
Samaneh Zandifar +3 more
doaj +1 more source

