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Brazilian Journal of Nephrology, 2023 Membranous nephropathy is a glomerulopathy, which main affected target is the podocyte, and has consequences on the glomerular basement membrane. It is more common in adults, especially over 50 years of age.
Márcio Dantas +5 more
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Rituximab in Membranous Nephropathy [PDF]
Kidney International Reports, 2021 Membranous nephropathy (MN) is the most common cause of primary nephrotic syndrome among adults. The identification of phospholipase A2 receptor (PLA2R) as target antigen in most patients changed the management of MN dramatically, and provided a rationale for B-cell depleting agents such as rituximab. The efficacy of rituximab in inducing remission has
Philipp Gauckler +77 more
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Journal of the Royal College of Physicians of London, 1997 link_to_subscribed_fulltext
Simon C Satchell, Peter W Mathieson
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Advances in Membranous Nephropathy [PDF]
Journal of Clinical Medicine, 2021 Membranous nephropathy (MN) is a rare auto-immune disease where the glomerulus is targeted by circulating auto-antibodies mostly against podocyte antigens, which results in the formation of electron-dense immune complexes, activation of complement and massive proteinuria.
Ronco, Pierre +2 more
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Treatment of membranous nephropathy [PDF]
Nephrology Dialysis Transplantation, 2001 Several therapeutic approaches have been tried in patients with membranous nephropathy. Corticosteroids have been largely used, but a meta-analysis of the available controlled trials did not show any benefit of corticosteroids either in favouring remission of the nephrotic syndrome or in preventing renal dysfunction.
Passerini Patrizia, Ponticelli Claudio
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IMMUNODIAGNOSIS IN MEMBRANOUS NEPHROPATHY
Wiadomości Lekarskie, 2020 One of the diseases leading to chronic end-stage renal disease is membranous nephropathy (MN). The main cause of this disease is the formation of antibodies to foreign and native antigens. Membranous nephropathy can be conventionally divided into 2 types: primary form (when the primary disease is unknown) and secondary form.
Magdalena, Ratajczak +2 more
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Lupus Membranous Nephropathy [PDF]
Glomerular Diseases, 2021 <b><i>Background:</i></b> Lupus membranous nephropathy (LMN) is a rare disease, usually associated with nephrotic syndrome. <b><i>Methods:</i></b> We reviewed the literature by searching for the following terms on Pubmed.gov: lupus nephritis, membranous nephropathy (MN), lupus membranous nephropathy ...
Ponticelli, Claudio +2 more
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Immunology of membranous nephropathy [PDF]
F1000Research, 2019 Accounting for about 20 to 50% of cases of primary nephrotic syndrome, membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults. A rat model created nearly 60 years ago to research the primary MN disorder, Heymann nephritis, has provided us with a plethora of important information.
Shin'ichi Akiyama +2 more
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Perspectives in membranous nephropathy [PDF]
Cell and Tissue Research, 2021 AbstractThe identification of the phospholipase A2 receptor 1 (PLA2R) and thrombospondin type-1 domain-containing protein 7A (THSD7A) as podocyte antigens in adult patients with membranous nephropathy (MN) has strongly impacted both experimental and clinical research on this disease. Evidence has been furnished that podocyte-directed autoantibodies can
Nicola M. Tomas +2 more
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Frontiers in Immunology, 2022 Thrombotic microangiopathy (TMA) is characterized by microangiopathic hemolytic anemia, thrombocytopenia and organ injury occurring due to endothelial cell damage and microthrombi formation in small vessels.
Maryam Saleem +4 more
doaj +1 more source