T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells. [PDF]
PLoS ONE, 2013 Memory T cells are composed of effector, central, and memory stem cells. Previous studies have implicated that both T-bet and Eomes are involved in the generation of effector and central memory CD8 T cells.
Gang Li +6 more
doaj +10 more sources
B cells negatively regulate the establishment of CD49b+T-bet+ resting memory T helper cells in the bone marrow [PDF]
Frontiers in Immunology, 2016 During an immune reaction, some antigen-experienced CD4 T cells relocate from secondary lymphoid organs (SLOs) to the bone marrow (BM) in a CD49b-dependent manner and reside and rest there as professional memory CD4 T cells.
Shintaro eHojyo +11 more
doaj +4 more sources
Development and function of protective and pathologic memory CD4 T cells [PDF]
, 2015 Immunological memory is one of the defining features of the adaptive immune system. As key orchestrators and mediators of immunity, CD4 T cells are central to the vast majority of adaptive immune responses.
Jaigirdar, Shafqat Ahrar +1 more
core +9 more sources
Human CD4 memory T cells can become CD4+IL-9+ T cells. [PDF]
PLoS ONE, 2010 IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-beta directs mouse CD4(+)CD25(-)CD62L(+) T cells to commit to inflammatory IL-9 producing CD4(+) T cells.Here we show that human ...
Prabhakar Putheti +4 more
doaj +1 more source
Memory regulatory T cells in pregnancy
Frontiers in Immunology, 2023 Pregnancy requires the process of maternal immune tolerance to semi-allogeneic embryos. In contrast, an overreactive maternal immune system to embryo-specific antigens is likely to result in the rejection of embryos while damaging the invading placenta ...
Zeyang Chen +5 more
doaj +1 more source
Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection. [PDF]
, 2020 The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than others to infection by HIV is not well understood.
Cavrois, Marielle +16 more
core +1 more source
Sepsis-induced changes in differentiation, maintenance, and function of memory CD8 T cell subsets
Frontiers in Immunology, 2023 Formation of long-lasting memory lymphocytes is one of the foundational characteristics of adaptive immunity and the basis of many vaccination strategies.
Mohammad Heidarian +4 more
doaj +1 more source
CD4(+)CD62L(+) central memory T cells can be converted to Foxp3(+) T cells. [PDF]
PLoS ONE, 2013 The peripheral Foxp3(+) Treg pool consists of naturally arising Treg (nTreg) and adaptive Treg cells (iTreg). It is well known that naive CD4(+) T cells can be readily converted to Foxp3(+) iTreg in vitro, and memory CD4(+) T cells are resistant to ...
Xiaolong Zhang +5 more
doaj +1 more source
Liposome-coupled peptides induce long-lived memory CD8 T cells without CD4 T cells. [PDF]
PLoS ONE, 2010 CD8(+) T cells provide broad immunity to viruses, because they are able to recognize all types of viral proteins. Therefore, the development of vaccines capable of inducing long-lived memory CD8(+) T cells is desired to prevent diseases, especially those
Maiko Taneichi +3 more
doaj +1 more source
Memory T follicular helper CD4 T cells
Frontiers in Immunology, 2015 T follicular helper (Tfh) cells are the subset of CD4 T helper cells that are required for generation and maintenance of germinal center reactions and the generation of long-lived humoral immunity.
J. Scott eHale, Rafi eAhmed
doaj +1 more source