Results 251 to 260 of about 1,044,819 (294)
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2006
T cell memory induced by prior infection or vaccination provides enhanced protection against subsequent microbial infections. The processes involved in generating and maintaining T cell memory are becoming better understood due to recent technological advances in identifying memory T cells and monitoring their behavior and function in vivo.
J T, Tan, C D, Surh
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T cell memory induced by prior infection or vaccination provides enhanced protection against subsequent microbial infections. The processes involved in generating and maintaining T cell memory are becoming better understood due to recent technological advances in identifying memory T cells and monitoring their behavior and function in vivo.
J T, Tan, C D, Surh
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Seminars in Immunology, 2004
CD4 T-cell memory is in some ways more enigmatic than CD8 T-cell memory. This is mostly due to the fact that CD4 T cells tend to expand far less in response to antigenic stimuli, thereby thwarting attempts at their detection during the course of an immune response.
Brigitta, Stockinger +2 more
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CD4 T-cell memory is in some ways more enigmatic than CD8 T-cell memory. This is mostly due to the fact that CD4 T cells tend to expand far less in response to antigenic stimuli, thereby thwarting attempts at their detection during the course of an immune response.
Brigitta, Stockinger +2 more
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Science, 1996
Viruses cause immediate induction of type I interferons (which include IFN-alpha and IFN-beta). These IFN I cytokines limit spread of the virus until antigen-specific responses can fully control the infection. A report by Tough et al . ( p.
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Viruses cause immediate induction of type I interferons (which include IFN-alpha and IFN-beta). These IFN I cytokines limit spread of the virus until antigen-specific responses can fully control the infection. A report by Tough et al . ( p.
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CD4 memory T cells on trial: immunological memory without a memory T cell
Trends in Immunology, 2008Immunological memory crucially depends on CD4 T cells. In contrast with B cells, we find no decisive evidence that CD4 T cells are permanently altered by antigen stimulation. We propose that the memory response is derived from an increase in frequency of resting naïve-like CD4 T cells with a half-life of years (or months in rodents), rather than the ...
Eric B, Bell, Jürgen, Westermann
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T cell-independent B cell memory
Current Opinion in Immunology, 2011Despite being unable to mount a bona fide recall antibody (Ab) response to secondary immunization, T cell-independent antigens (TI Ag) such as pneumococcal capsular polysaccharides (PS) can generate protective humoral immunity in adults. The concept of TI B cell memory after being iconoclastic for decades has now received experimental support from ...
Thierry, Defrance +2 more
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Nature, 2000
Memory is a long-recognized, crucial and poorly understood property of adaptive immunity. Jacob and Baltimore have designed an elegant genetic approach to marking memory T cells and their precursors irreversibly and have obtained intriguing results.
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Memory is a long-recognized, crucial and poorly understood property of adaptive immunity. Jacob and Baltimore have designed an elegant genetic approach to marking memory T cells and their precursors irreversibly and have obtained intriguing results.
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Journal of Theoretical Biology, 1994
A new mathematical model of T helper-cell activation and proliferation is investigated. The model incorporates recent data and theories about memory T cells. It accounts for the interacting population dynamics of resting, activated and memory T helper cells, interleukin 2 and replicating antigen, and is able to mimic a broad range of available data on ...
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A new mathematical model of T helper-cell activation and proliferation is investigated. The model incorporates recent data and theories about memory T cells. It accounts for the interacting population dynamics of resting, activated and memory T helper cells, interleukin 2 and replicating antigen, and is able to mimic a broad range of available data on ...
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1990
The immune response of the host to its environment necessitates a finely tuned network of feedback mechanisms designed to provide for an effective humoral and cellular response to potential pathogens without damage to self tissues. Therefore the maintenance of the immunological milieu interieur depends not only on counterbalances to regulate the extent
S, Adelstein +3 more
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The immune response of the host to its environment necessitates a finely tuned network of feedback mechanisms designed to provide for an effective humoral and cellular response to potential pathogens without damage to self tissues. Therefore the maintenance of the immunological milieu interieur depends not only on counterbalances to regulate the extent
S, Adelstein +3 more
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Current Opinion in Immunology, 2011
Memory CD4+ T cells specific for a given antigen are generated during the primary response from the effector lymphoblast progeny of naïve precursors. How memory CD4+ T cells differentiate from the effector population is not understood but new tools to assess transcription factor and cytokine expression are allowing for a more careful assessment of this
Justin J, Taylor, Marc K, Jenkins
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Memory CD4+ T cells specific for a given antigen are generated during the primary response from the effector lymphoblast progeny of naïve precursors. How memory CD4+ T cells differentiate from the effector population is not understood but new tools to assess transcription factor and cytokine expression are allowing for a more careful assessment of this
Justin J, Taylor, Marc K, Jenkins
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Current Opinion in Immunology, 2007
The observation that individuals living in malaria endemic areas fail to develop sterilizing immunity to malaria infection has led to the assumption that malaria-specific immune responses are sub-optimal. Recently, T cell receptor (TCR) transgenic mice specific for the sporozoite and blood stages of the malaria parasite have been developed.
Ian A, Cockburn, Fidel, Zavala
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The observation that individuals living in malaria endemic areas fail to develop sterilizing immunity to malaria infection has led to the assumption that malaria-specific immune responses are sub-optimal. Recently, T cell receptor (TCR) transgenic mice specific for the sporozoite and blood stages of the malaria parasite have been developed.
Ian A, Cockburn, Fidel, Zavala
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