Results 21 to 30 of about 1,039,467 (200)

T cell memory [PDF]

Seminars in Immunology, 2009
There is perhaps no more important function of the adaptive immune system than to confer protection from reinfection by pathogens previously encountered and defeated. Within the T cell lineage, this property of remembering past antigenic threats resides in the small subset of memory cells which persist long after the disappearance of the short-lived ...
openaire   +2 more sources

Vaccination Expands Antigen-Specific CD4+ Memory T Cells and Mobilizes Bystander Central Memory T Cells.

PLoS ONE, 2015
CD4+ T helper memory (Thmem) cells influence both natural and vaccine-boosted immunity, but mechanisms for their maintenance remain unclear. Pro-survival signals from the common gamma-chain cytokines, in particular IL-7, appear important.
Eleonora Li Causi, Suraj C Parikh, Lindsey Chudley, David M Layfield, Christian H Ottensmeier, Freda K Stevenson, Gianfranco Di Genova   +6 more
doaj   +1 more source

Memory T Cells in Flavivirus Vaccination

Vaccines, 2018
Flaviviruses include many medically important viruses, such as Dengue virus (DENV), Japanese encephalitis (JEV), tick-borne encephalitis (TBEV), West Nile (WNV), yellow fever (YFV), and Zika viruses (ZIKV).
Guangyu Li, Cody Teleki, Tian Wang
doaj   +1 more source

Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels [PDF]

, 2017
Characterising the longevity of immunological memory requires establishing the rules underlying the renewal and death of peripheral T cells. However, we lack knowledge of the population structure and how self-renewal and de novo influx contribute to ...
Asquith, Asquith, Asquith, Beura, Bingaman, Bjorkdahl, Bonhoeffer, Borghans, Bruno, Chao, Choo, De Boer, De Boer, De Boer, De Boer, Debacq, Ganusov, Ganusov, Grossman, Hogan, Hogan, Hogan, Hogan, Homann, Kassiotis, Le Campion, Leignadier, Lenz, Macallan, Min, Mohri, Mohri, Nelson, Parretta, Pepper, Pitcher, Purton, Restifo, Ribeiro, Robertson, Seddon, Surh, Tough, Vezys, Vrisekoop, Westera, Yates, Younes   +47 more
core   +4 more sources

Metabolic features of naïve and memory CD4⁺T cells in quiescence and during proliferation

Acta Biomedica Scientifica, 2022
Background. Memory CD4+ T cells proliferation is the basis for accelerated secondary immune response. The characteristics of memory CD4+ T cells providing their faster division compared to naive CD4+ T lymphocytes are poorly understood.
V. V. Vlasova, E. V. Saidakova, L. B. Korolevskaya, N. G. Shmagel, K. V. Shmagel   +4 more
doaj   +1 more source

Adenovirus vector-specific T cells demonstrate a unique memory phenotype with high proliferative potential and coexpression of CCR5 and integrin α\(_4\)β\(_7\) [PDF]

, 2009
Background: The Step Study was a randomized trial to reduce HIV infection through vaccination with an adenovirus type 5-based gag/pol/nef construct; analysis following early cessation of the trial revealed an excess of HIV seroconversion in Ad5 ...
Chakupurakal, Geothy, Cobbold, Mark, Mautner, Vivien, Moss, Paul AH, Onion, David   +4 more
core   +1 more source

Distinct CD4−CD8− (Double-Negative) Memory T-Cell Subpopulations Are Associated With Indeterminate and Cardiac Clinical Forms of Chagas Disease

Frontiers in Immunology, 2021
CD4−CD8− (double-negative, DN) T cells are critical orchestrators of the cytokine network associated with the pathogenic inflammatory response in one of the deadliest cardiomyopathies known, Chagas heart disease, which is caused by Trypanosoma cruzi ...
Livia Silva Araújo Passos, Livia Silva Araújo Passos, Carolina Cattoni Koh, Luísa Mourão Dias Magalhães, Luísa Mourão Dias Magalhães, Maria do Carmo Pereira Nunes, Kenneth John Gollob, Kenneth John Gollob, Walderez Ornelas Dutra, Walderez Ornelas Dutra, Walderez Ornelas Dutra   +10 more
doaj   +1 more source

Transcriptional repressor ZEB2 promotes terminal differentiation of CD8⁺ effector and memory T cell populations during infection [PDF]

, 2015
ZEB2 is a multi-zinc-finger transcription factor known to play a significant role in early neurogenesis and in epithelial-mesenchymal transition-dependent tumor metastasis.
Agata Stryjewska, Alexander Weidemann, Ananda W. Goldrath, Best, Bingfei Yu, Brabletz, Cannarile, Christiane Zweier, Conidi, Danny Huylebroeck, Engel, Eve Seuntjens, Garavelli, Gattinoni, Goldrath, Goossens, Goossens, Grégoire, Gründemann, Hand, Haring, Harney, Harney, Harty, Higashi, Higashi, Hikono, Hikono, Hisato Kondoh, J. Adam Best, Jessica V. Nguyen, Jody Haigh, Joshi, Kaech, Kaech, Kaech, Kaech, Kallies, Knell, Kyla D. Omilusik, Larabee, Lin, Luca Gattinoni, Lynne M. Bird, Massari, Masson, Mowat, Murre, Olson, Postigo, Postigo, Rahul Roychoudhuri, Remacle, Rice, Rubinstein, Sarkar, Sawada, Sekido, Seuntjens, Steven Goossens, Takemoto, Van de Putte, van den Berghe, van Grunsven, Verschueren, Verstappen, Voehringer, Williams, Wirth, Yang, Yasui, Yujiro Higashi, Zweier   +72 more
core   +3 more sources

Apoptotic epitope-specific CD8+ T cells and interferon signaling intersect in chronic hepatitis C virus infection [PDF]

, 2015
CD8(+) T cells specific to caspase-cleaved antigens derived from apoptotic T cells represent a principal player in chronic immune activation (CIA). Here, we found that both apoptotic epitope (AE)-specific and hepatitis C virus (HCV)-specific CD8(+) T ...
Accapezzato, Daniele, Barnaba, Vincenzo, Calvo, Ludovica, Cavallari, EUGENIO NELSON, Citro, Alessandra, Coccia, Eliana M, D'Ettorre, Gabriella, DE MARZIO, Paolo, DI FILIPPO, Simona, Grazi, Gian Luca, Labbadia, Giancarlo, Martini, Helene, Martire, Carmela, Piconese, Silvia, Rizzo, Fabiana, Sette, Alessandro, Severa, Martina, Sidney, John, Vullo, Vincenzo   +18 more
core   +1 more source

T cell aging: A review of the transcriptional changes determined from genome-wide analysis

Frontiers in Immunology, 2013
Age carries a detrimental impact on T cell function. In the past decade, analyses of the genome-scale transcriptional changes of T cells during aging have yielded a large amount of data and provided a global view of gene expression changes in T cells ...
Guobing eChen, Ana eLustig, Nan-ping eWeng   +2 more
doaj   +1 more source