Results 41 to 50 of about 1,039,467 (200)
Sustained Id2 regulation of E proteins is required for terminal differentiation of effector CD8+ T cells. [PDF]
, 2018 CD8+ T cells responding to infection differentiate into a heterogeneous population composed of progeny that are short-lived and participate in the immediate, acute response and those that provide long-lasting host protection.
Goldrath, Ananda W +5 more
core +1 more source
Transcript-indexed ATAC-seq for precision immune profiling. [PDF]
, 2018 T cells create vast amounts of diversity in the genes that encode their T cell receptors (TCRs), which enables individual clones to recognize specific peptide-major histocompatibility complex (MHC) ligands. Here we combined sequencing of the TCR-encoding
Buenrostro, Jason D +21 more
core +1 more source
Early Investigations and Recent Advances in Intraperitoneal Immunotherapy for Peritoneal Metastasis. [PDF]
, 2018 Peritoneal metastasis (PM) is an advanced stage malignancy largely refractory to modern therapy. Intraperitoneal (IP) immunotherapy offers a novel approach for the control of regional disease of the peritoneal cavity by breaking immune tolerance.
Bowne, Wilbur B. +5 more
core +2 more sources
Biology of Blood and Marrow Transplantation, 2008 Memory. is the diary that we all carry about with us. Oscar Wilde, ‘‘The Importance of Being Earnest’’ And so it is with the immune system. Memory T cells are a critical component of the adaptive immune system. Our ability to respond rapidly to antigens/ pathogens that we have been exposed to previously is at the heart of the adaptive immune system. In
openaire +2 more sources
PLoS ONE, 2017 IntroductionHIV causes defects in memory B cells in children, but the mechanisms of those defects have not been fully elucidated. One possible mechanism is the lack of T-cell help to B cells during immune reactions. However, few studies have assessed the
Daniel M Muema +7 more
doaj +1 more source
Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1. [PDF]
, 2017 The expansion of CD8+CD28- T cells, a population of terminally differentiated memory T cells, is one of the most consistent immunological changes in humans during aging.
Fei, Mingjian +11 more
core +1 more source
Tissue‐resident memory T cells [PDF]
Immunological Reviews, 2013 SummaryTissues such as the genital tract, skin, and lung act as barriers against invading pathogens. To protect the host, incoming microbes must be quickly and efficiently controlled by the immune system at the portal of entry. Memory is a hallmark of the adaptive immune system, which confers long‐term protection and is the basis for efficacious ...
Haina, Shin, Akiko, Iwasaki
openaire +2 more sources
Role of Immunological Memory Cells as a Therapeutic Target in Multiple Sclerosis
Brain Sciences, 2017 Pharmacological targeting of memory cells is an attractive treatment strategy in various autoimmune diseases, such as psoriasis and rheumatoid arthritis.
Tanima Bose
doaj +1 more source
Regulatory T cells in melanoma revisited by a computational clustering of FOXP3+ T cell subpopulations [PDF]
, 2015 CD4+ T cells that express the transcription factor FOXP3 (FOXP3+ T cells) are commonly regarded as immunosuppressive regulatory T cells (Treg). FOXP3+ T cells are reported to be increased in tumour-bearing patients or animals, and considered to suppress ...
Fujii, H +5 more
core +3 more sources
The TreaT-Assay: A Novel Urine-Derived Donor Kidney Cell-Based Assay for Prediction of Kidney Transplantation Outcome [PDF]
, 2019 Donor-reactive immunity plays a major role in rejection after kidney transplantation, but analysis of donor-reactive T-cells is not applied routinely. However, it has been shown that this could help to identify patients at risk of acute rejection.
Babel, Nina +15 more
core +1 more source