Results 1 to 10 of about 314,978 (365)

Addressing the credibility crisis in Mendelian randomization

BMC Medicine
Background Genome-wide association studies have enabled Mendelian randomization analyses to be performed at an industrial scale. Two-sample summary data Mendelian randomization analyses can be performed using publicly available data by anyone who has ...
Stephen Burgess, Benjamin Woolf, Amy M. Mason, Mika Ala-Korpela, Dipender Gill   +4 more
doaj   +2 more sources

Association of insomnia and daytime sleepiness with low back pain: A bidirectional mendelian randomization analysis

Frontiers in Genetics, 2022
Purpose: Observational research has indicated the presence of a causal relationship between sleep disturbances and low back pain (LBP). However, the link may have been biased by confounding factors.
Peng Shu, Lixian Ji, Zichuan Ping, Zhibo Sun, Wei Liu   +4 more
doaj   +1 more source

Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR Statement.

Journal of the American Medical Association (JAMA), 2021
Importance Mendelian randomization (MR) studies use genetic variation associated with modifiable exposures to assess their possible causal relationship with outcomes and aim to reduce potential bias from confounding and reverse causation.
V. Skrivankova, R. Richmond, B. Woolf, J. Yarmolinsky, N. Davies, S. Swanson, T. VanderWeele, J. Higgins, N. Timpson, N. Dimou, C. Langenberg, Robert M. Golub, E. Loder, V. Gallo, A. Tybjaerg-hansen, G. Davey Smith, M. Egger, J. B. Richards   +17 more
semanticscholar   +1 more source

Is it possible to implement a rare disease case-finding tool in primary care? A UK-based pilot study

Orphanet Journal of Rare Diseases, 2022
Introduction This study implemented MendelScan, a primary care rare disease case-finding tool, into a UK National Health Service population. Rare disease diagnosis is challenging due to disease complexity and low physician awareness.
Orlando Buendia, Sneha Shankar, Hadley Mahon, Connor Toal, Lara Menzies, Pradeep Ravichandran, Jane Roper, Jag Takhar, Rudy Benfredj, Will Evans   +9 more
doaj   +1 more source

Genetic and karyotype divergence between parents affect clonality and sterility in hybrids

eLife, 2023
Asexual reproduction can be triggered by interspecific hybridization, but its emergence is supposedly rare, relying on exceptional combinations of suitable genomes.
Anatolie Marta, Tomáš Tichopád, Oldřich Bartoš, Jiří Klíma, Mujahid Ali Shah, Vendula Šlechtová Bohlen, Joerg Bohlen, Karel Halačka, Lukáš Choleva, Matthias Stöck, Dmitrij Dedukh, Karel Janko   +11 more
doaj   +1 more source

Mendelian randomization for cardiovascular diseases: principles and applications

European Heart Journal, 2023
Large-scale genome-wide association studies conducted over the last decade have uncovered numerous genetic variants associated with cardiometabolic traits and risk factors.
Susanna C. Larsson, A. Butterworth, Stephen Burgess   +2 more
semanticscholar   +1 more source

Unveiling the Mysteries of Non-Mendelian Heredity in Plant Breeding

Plants, 2023
Mendelian heredity is the cornerstone of plant breeding and has been used to develop new varieties of plants since the 19th century. However, there are several breeding cases, such as cytoplasmic inheritance, methylation, epigenetics, hybrid vigor, and ...
Mohsen Yoosefzadeh Najafabadi, Mohsen Hesami, Istvan Rajcan   +2 more
doaj   +1 more source

Causal role of immune cells in schizophrenia: Mendelian randomization (MR) study

BMC Psychiatry, 2023
Background Complex immune-brain interactions that affect neural development, survival and function might have causal and therapeutic implications for psychiatric illnesses.
Chengdong Wang, Dongdong Zhu, Dongjun Zhang, Xiaowei Zuo, Lei Yao, Teng Liu, Xiaodan Ge, Chenlu He, Yuan Zhou, Ziyuan Shen   +9 more
semanticscholar   +1 more source

Potential drug targets for multiple sclerosis identified through Mendelian randomization analysis

Brain : a journal of neurology, 2023
Multiple sclerosis is a complex autoimmune disease, and several therapies for multiple sclerosis have been developed and widely used. However, existing medications for multiple sclerosis were far from satisfactory due to their failure to suppress ...
Jianfeng Lin, Jiawei Zhou, Yan Xu
semanticscholar   +1 more source

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis [PDF]

, 2020
Background A non-invasive method to grade the severity of steatohepatitis and liver fibrosis is magnetic resonance imaging (MRI) based corrected T1 (cT1).
Banerjee, R, Banerjee, R, Bell, J.D., Bell, J.D., Hemingway, H., Hemingway, H., Hingorani, A.D., Hingorani, A.D., Kelly, M., Kelly, M., McGonigle, J., McGonigle, J., Neubauer, S., Neubauer, S., Nicholls, R.C., Nicholls, R.C., Parisinos, C.A., Parisinos, C.A., Patel, R.S., Patel, R.S., Thomas, E.L., Thomas, E.L., Wilman, H., Wilman, H., Yaghootkar, H., Yaghootkar, H.   +25 more
core   +3 more sources