Results 161 to 170 of about 236,698 (345)
ESC Heart Failure, EarlyView.Abstract Aims Gut dysbiosis is proven to be involved in the pathogenesis and progression of heart failure (HF). Hindering the detrimental effects of gut‐heart axis is an emerging trend. Our goal is to investigate the causal relationship between gut microbiota and HF, with the aim of facilitating future exploration of microbiome‐targeted approaches to ...
Liyan Huang +8 more
wiley +1 more source
Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023 The incidence of acute pancreatitis is increasing over years especially in western countries, but the etiologies of acute pancreatitis have not been well understood. And it is unclear whether the reported possible risk factors are real causes of acute pancreatitis.
Qiu‐Yi Tang +8 more
wiley +1 more source
Leveraging Local Distributions in Mendelian Randomization: Uncertain Opinions are Invalid [PDF]
arXivMendelian randomization (MR) considers using genetic variants as instrumental variables (IVs) to infer causal effects in observational studies. However, the validity of causal inference in MR can be compromised when the IVs are potentially invalid. In this work, we propose a new method, MR-Local, to infer the causal effect in the existence of possibly ...
arxiv
Integrating summarized data from multiple genetic variants in Mendelian randomization: bias and coverage properties of inverse-variance weighted methods [PDF]
arXiv, 2015 Mendelian randomization is the use of genetic variants as instrumental variables to assess whether a risk factor is a cause of a disease outcome. Increasingly, Mendelian randomization investigations are conducted on the basis of summarized data, rather than individual-level data.
arxiv
The chemical interpretation of some Mendelian factors for flower-colour [PDF]
, 1914 M. Wheldale, H. Ll. Bassett
openalex +1 more source
ESC Heart Failure, EarlyView.Systematic approach to dilated cardiomyopathy diagnosis. Dilated cardiomyopathy is a clinical diagnosis characterized by the presence of left ventricular dilatation and systolic disfunction unexplained by abnormal loading conditions or coronary artery disease.
Kristian Galanti +14 more
wiley +1 more source
Using reported pathogenic variants to identify therapeutic opportunities for genetic diseases
Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023 The increase in size of publicly available variant annotation and Mendelian disease databases have allowed for novel approaches to identify the likely direction of effect of genetic mutations. Specifically, we found a simple ratio of missense mutations is capable of identifying genes likely to cause disease through a gain‐of‐function mechanism ...
Andrew K. Ressler, David B. Goldstein
wiley +1 more source
Multiomics insight into the role of glucagon‐like peptide‐1 receptor agonists in heart failure
ESC Heart Failure, EarlyView.Graphical abstract of the multiomics insight into the role of GLP1Ra in cardiovascular diseases and the underlying pathway. GLP1Ra, glucagon‐like peptide‐1 receptor agonist. Abstract Aims Cardiovascular diseases, such as atrial fibrillation, coronary artery disease, heart failure (HF) and ischaemic stroke, are leading causes of death globally and exert
Yuhang Tao +6 more
wiley +1 more source