Results 161 to 170 of about 314,978 (365)

Causal effects of B vitamins and homocysteine on obesity and musculoskeletal diseases: A Mendelian randomization study

, 2022
Liwan Fu, Yuquan Wang, Yue‐Qing Hu
openalex   +1 more source

The serum lipid profiles in immune thrombocytopenia: Mendelian randomization analysis and a retrospective study [PDF]

, 2023
Pengcheng Xu, Shouqing Han, Ming Hou, Yajing Zhao, Miao Xu   +4 more
openalex   +1 more source

Assessing the causal relationship between the plasma proteome and epilepsy: A Mendelian randomization study

Epilepsia Open, EarlyView.
Abstract Objective Understanding the role of plasma proteins in the pathophysiology of epilepsy is crucial for uncovering novel biological mechanisms and therapeutic targets. Mendelian randomization (MR) provides a valuable tool for dissecting potentially causal associations between circulating proteins and disease risk.
Jingfeng Fu, Wei Wu, Shangren Shen
wiley   +1 more source

Causal and mediating effects of lipid and facial aging: association study integrating GWAS, eQTL, mQTL, and pQTL data

Lipids in Health and Disease
Background Increasing evidence suggests a potential causal association between lipid levels and facial aging. The aim of this study was to investigate the relationship between levels of specific lipids and facial aging via Mendelian randomization methods.
Mingjian Zhao, Zhanchen He, Lukuan Liu, Yichen Wang, LinQi Gao, Yuxuan Shang, Mengru Zhu   +6 more
doaj   +1 more source

Causal Effect of Relative Carbohydrate Intake on Hypertension through Psychological Well-Being and Adiposity: A Mendelian Randomization Study [PDF]

, 2023
Chaojie Ye, Lijie Kong, Yiying Wang, Chun Dou, Min Xu, Jie Zheng, Ruizhi Zheng, Yu Xu, Mian Li, Zhiyun Zhao, Jieli Lu, Yuhong Chen, Weiqing Wang, Yufang Bi, Tiange Wang, Guang Ning   +15 more
openalex   +1 more source

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Promise and Peril of a Genotype‐First Approach to Mendelian Cardiovascular Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Precision medicine, which among other aspects includes an individual's genomic data in diagnosis and management, has become the standard‐of‐care for Mendelian cardiovascular disease (CVD).
Babken Asatryan, Brittney Murray, Rafik Tadros, Marina Rieder, Ravi A. Shah, Ghaith Sharaf Dabbagh, Andrew P. Landstrom, Stephan Dobner, Patricia B. Munroe, Christopher M. Haggerty, Argelia Medeiros‐Domingo, Anjali T. Owens, Iftikhar J. Kullo, Christopher Semsarian, Tobias Reichlin, Andreas S. Barth, Dan M. Roden, Cynthia A. James, James S. Ware, C. Anwar A. Chahal   +19 more
doaj   +1 more source

Genetic markers as instrumental variables: an application to child fat mass and academic achievement [PDF]

The use of genetic markers as instrumental variables (IV) is receiving increasing attention from economists. This paper examines the conditions that need to be met for genetic variants to be used as instruments.
Carol Propper, Debbie A. Lawlor, Frank Windmeijer, George Davey Smith, Stephanie von Hinke Kessler Scholder   +4 more
core  

Interleukin-6 signaling effects on ischemic stroke and other cardiovascular outcomes: a Mendelian Randomization study [PDF]

, 2019
Marios K. Georgakis, Rainer Malik, Dipender Gill, Nora Franceschini, Cathie Sudlow, Martin Dichgans   +5 more
openalex   +1 more source

Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: a within-family Mendelian randomization study [PDF]

, 2021
Amanda Hughes, Eleanor Sanderson, Tim Morris, Ziada Ayorech, Martin Tesli, Helga Ask, Ted Reichborn‐Kjennerud, Ole A. Andreassen, Per Magnus, Øyvind Helgeland, Stefan Johansson, Pål R. Njølstad, George Davey Smith, Alexandra Havdahl, Laura D. Howe, Neil M Davies   +15 more
openalex   +1 more source