Results 191 to 200 of about 314,978 (365)
Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.ABSTRACT Background Understanding the genetic links between acute pancreatitis (AP) and its infectious comorbidities is crucial for prognosis and therapy, yet remains underexplored. Methods We conducted a comprehensive post‐GWAS analysis using large‐scale summary statistics for AP and 16 infectious diseases. To pinpoint pleiotropic genes, we integrated
Bo Zou +6 more
wiley +1 more source
Journal of Periodontology, EarlyView.Abstract Background To examine whether the associations between periodontitis and multiple systemic conditions increase with increasing severity of periodontitis using a multi‐center electronic health record (EHR) repository. Methods A cross‐sectional analysis was conducted using EHR data from 9 dental schools in the United States.
Muhammad H. A. Saleh, Hamoun Sabri
wiley +1 more source
Commentary: Role of vitamin D in disease through the lens of Mendelian randomization—Evidence from Mendelian randomization challenges the benefits of vitamin D supplementation for disease prevention [PDF]
, 2019 Despoina Manousaki, J. Brent Richards
openalex +1 more source
Medicine Bulletin, EarlyView.ABSTRACT Background To evaluate the associations of systemic diseases with AMD incidence and explore whether polygenic risk score (PRS) for AMD influences these associations. To assess the impacts of polymorbidities and serum biomarkers on AMD risk. Methods This prospective study of 471156 AMD‐free UK Biobank participants assessed systemic diseases ...
Jun Yu +9 more
wiley +1 more source
MendelR: A One‐Stop R Toolkit for Mendelian Randomization Analysis
Med Research, EarlyView.ABSTRACT MendelR is a fully automated R package specifically developed for Mendelian randomization (MR) studies, designed to address the technical challenges of causal inference in biomedical research. As a powerful causal inference method, Mendelian randomization can effectively reduce confounding bias in observational studies.
Xiaohong Ke +4 more
wiley +1 more source
Compound Heterozygous Structural Variants in Cases with Unsolved PRKN‐Associated Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background Biallelic mutations in the PRKN gene are a common cause of early‐onset Parkinson's disease (EOPD). In addition to single nucleotide variants, structural variants contribute substantially to the mutational profile of PRKN. A significant portion of patients with EOPD remains genetically unsolved.
Agata Fant +24 more
wiley +1 more source