Results 21 to 30 of about 314,978 (365)
Mendelian and Non-Mendelian Quadratic Operators [PDF]
Applied Mathematics & Information Sciences, 2013 In this paper, we attempt to provide mathematical models of Mendelian and Non-Mendelian inheritances of the bisexual population system having Fisher's {\textbf{1:1}} principle. In our model, we always assume that distributions of the same phenotype of female and male populations are equal. We study the evolution of a Mendelian trait.
Ganikhodjaev, Nasir +2 more
openaire +2 more sources
International Journal of Epidemiology, 2015 Background: The number of Mendelian randomization analyses including large numbers of genetic variants is rapidly increasing. This is due to the proliferation of genome-wide association studies, and the desire to obtain more precise estimates of causal ...
J. Bowden, G. Davey Smith, S. Burgess
semanticscholar +1 more source
BMC Medicine, 2023 Background Persistent infection by oncogenic human papillomavirus (HPV) is necessary although not sufficient for development of cervical cancer. Behavioural, environmental, or comorbid exposures may promote or protect against malignant transformation ...
S. Bowden +13 more
semanticscholar +1 more source
An heuristic filtering tool to identify phenotype-associated genetic variants applied to human intellectual disability and canine coat colors [PDF]
, 2015 Background: Identification of one or several disease causing variant(s) from the large collection of variants present in an individual is often achieved by the sequential use of heuristic filters.
Bosmans, Tim +8 more
core +5 more sources
Interpreting findings from Mendelian randomization using the MR-Egger method
European Journal of Epidemiology, 2017 Mendelian randomization-Egger (MR-Egger) is an analysis method for Mendelian randomization using summarized genetic data. MR-Egger consists of three parts: (1) a test for directional pleiotropy, (2) a test for a causal effect, and (3) an estimate of the ...
S. Burgess, S. Thompson
semanticscholar +1 more source
Wellcome Open Research, 2023 The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data.
Ashish Patel +7 more
semanticscholar +1 more source
Monogenic Lupus: A Developing Paradigm of Disease
Frontiers in Immunology, 2018 Monogenic lupus is a form of systemic lupus erythematosus (SLE) that occurs in patients with a single gene defect. This rare variant of lupus generally presents with early onset severe disease, especially affecting the kidneys and central nervous system.
Jessie M. Alperin +3 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2022 ObjectiveThis study aimed to estimate the causal effects of Coronavirus disease 2019 susceptibility and hospitalization on cardiovascular disease death using two-sample Mendelian randomization analysis.MethodsWe used statistics from a genome-wide ...
Jia-peng Miao, Xiao-yu Gu, Rui-zheng Shi
doaj +1 more source
Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
British medical journal, 2018 Mendelian randomisation uses genetic variation as a natural experiment to investigate the causal relations between potentially modifiable risk factors and health outcomes in observational data.
N. Davies, M. Holmes, G. Davey Smith
semanticscholar +1 more source
Celer: an Efficient Program for Genotype Elimination [PDF]
Electronic Proceedings in Theoretical Computer Science, 2010 This paper presents an efficient program for checking Mendelian consistency in a pedigree. Since pedigrees may contain incomplete and/or erroneous information, geneticists need to pre-process them before performing linkage analysis.
Nicoletta De Francesco +2 more
doaj +1 more source