Evolution of dominance in gene expression pattern associated with phenotypic robustness
BMC Ecology and Evolution, 2021 Background Mendelian inheritance is a fundamental law of genetics. When we consider two genomes in a diploid cell, a heterozygote’s phenotype is dominated by a particular homozygote according to the law of dominance.
Kenji Okubo, Kunihiko Kaneko
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Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts [PDF]
, 2013 Objectives: To assess the associations between both uric acid levels and hyperuricaemia, with ischaemic heart disease and blood pressure, and to explore the potentially confounding role of body mass index. Design: Mendelian randomisation analysis, using
Benn, Marianne +6 more
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Causal analysis between gastro-oesophageal reflux disease and obstructive sleep apnoea
ERJ Open Research, 2023 Background Based on evidence from existing observational research, clarifying the causal relationship between gastro-oesophageal reflux disease (GORD) and obstructive sleep apnoea (OSA) is challenging.
Gui Chen +8 more
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Wellcome Open Research, 2020 The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data. In this manuscript, we describe functions that have been added to the package or
Jim R. Broadbent +5 more
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Allelic segregation and independent assortment in T. brucei crosses: proof that the genetic system is Mendelian and involves meiosis [PDF]
, 2005 The genetic system on Trypanosoma brucei has been analysed by generating large numbers of independent progeny clones from two crosses, one between two cloned isolates of Trypanosoma brucei brucei and one between cloned isolates of T. b.
Alison Tweedie +44 more
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Interaction Between Mendelian and Non-Mendelian Genes. Regulation of the Transmission of Non-Mendelian Genes by a Mendelian Gene In Chlamydomonas reinhardtii [PDF]
Proceedings of the National Academy of Sciences, 1974 The non-Mendelian genetic element of a given mating type of Chlamydomonas reinhardtii was first doubly marked by succesive mutageneses and then transferred into a number of offspring cells of the opposite mating type.
Orchid M. Y. Chu-Der, Kwen-Sheng Chiang
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Mendelian Randomization: Concepts and Scope [PDF]
Cold Spring Harbor Perspectives in Medicine, 2021 Mendelian randomization (MR) is a method of studying the causal effects of modifiable exposures (i.e., potential risk factors) on health, social, and economic outcomes using genetic variants associated with the specific exposures of interest. MR provides a more robust understanding of the influence of these exposures on outcomes because germline ...
George Davey Smith +2 more
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Statistical methods for Mendelian models with multiple genes and cancers [PDF]
arXiv, 2021 Risk evaluation to identify individuals who are at greater risk of cancer as a result of heritable pathogenic variants is a valuable component of individualized clinical management. Using principles of Mendelian genetics, Bayesian probability theory, and variant-specific knowledge, Mendelian models derive the probability of carrying a pathogenic ...
arxiv
Survey of variation in human transcription factors reveals prevalent DNA binding changes [PDF]
, 2016 Published in final edited form as: Science. 2016 Mar 25; 351(6280): 1450–1454. Published online 2016 Mar 24. doi: 10.1126/science.aad2257Sequencing of exomes and genomes has revealed abundant genetic variation affecting the coding sequences of human ...
Barrera, Luis A. +21 more
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