Results 61 to 70 of about 245,577 (122)

Evaluating the causal relationship of Levo-carnitine and risk of schizophrenia: a bidirectional two-sample mendelian randomization study

BMC Psychiatry
Background Schizophrenia is a debilitating mental disorder affecting about 1% of the global population, characterized by significant cognitive impairments and a strong hereditary component.
Haoyuan Qiu, Zicheng Zhong, Tianxing Wu, Haoran Hu, Meijuan Zhou, Zhijun Feng   +5 more
doaj   +1 more source

Does ankylosing spondylitis exert a bidirectional influence on hypertension? A two-sample Mendelian randomization study

SAGE Open Medicine
Objective: Previous observational studies reported that ankylosing spondylitis is closely related to hypertension. However, it is still controversial whether the association between ankylosing spondylitis and hypertension is causal.
Weiran Hu, Kai Zhang, Guang Yang, Haoxu Wang, Yanzheng Gao   +4 more
doaj   +1 more source

Genetic architecture of heritable leaf microbes

Microbiology Spectrum
Host-associated microbiomes are shaped by both their environment and host genetics, and often impact host performance. The scale of host genetic variation important to microbes is largely unknown yet fundamental to the community assembly of host ...
Julia A. Boyle, Megan E. Frederickson, John R. Stinchcombe   +2 more
doaj   +1 more source

Causal and mediating effects of lipid and facial aging: association study integrating GWAS, eQTL, mQTL, and pQTL data

Lipids in Health and Disease
Background Increasing evidence suggests a potential causal association between lipid levels and facial aging. The aim of this study was to investigate the relationship between levels of specific lipids and facial aging via Mendelian randomization methods.
Mingjian Zhao, Zhanchen He, Lukuan Liu, Yichen Wang, LinQi Gao, Yuxuan Shang, Mengru Zhu   +6 more
doaj   +1 more source

Promise and Peril of a Genotype‐First Approach to Mendelian Cardiovascular Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Precision medicine, which among other aspects includes an individual's genomic data in diagnosis and management, has become the standard‐of‐care for Mendelian cardiovascular disease (CVD).
Babken Asatryan, Brittney Murray, Rafik Tadros, Marina Rieder, Ravi A. Shah, Ghaith Sharaf Dabbagh, Andrew P. Landstrom, Stephan Dobner, Patricia B. Munroe, Christopher M. Haggerty, Argelia Medeiros‐Domingo, Anjali T. Owens, Iftikhar J. Kullo, Christopher Semsarian, Tobias Reichlin, Andreas S. Barth, Dan M. Roden, Cynthia A. James, James S. Ware, C. Anwar A. Chahal   +19 more
doaj   +1 more source

Causal association of plasminogen activators and their inhibitors with Alzheimer’s disease: a Mendelian randomization study

Archives of Medical Science
Introduction Alzheimer’s disease (AD) is the most common cause of dementia and contributes to a huge burden of disease worldwide. Observational studies have found that tissue plasminogen activator (t-PA) inhibits the development of AD, but little is ...
Xin Guo, Fangyu Gao, Baolong Pan, Feng Gao, Jingsi Zhang, Shanshan Wang, Qiao Niu   +6 more
doaj   +1 more source

Mendelian Randomisation: Concepts, Opportunities, Challenges, and Future Directions

Global Heart
Mendelian randomisation is an approach in genetic epidemiology that uses genetic variants as instrumental variables to investigate the causal relationship between genetically proxied exposures and health outcomes.
Sophie C. de Ruiter, Lena Tschiderer, Diederick E. Grobbee, Peter Willeit, Hester M. den Ruijter, A. Floriaan Schmidt, Sanne A. E. Peters   +6 more
doaj   +1 more source

Causal association between periodontitis and systemic diseases: a systematic review and meta-analysis of mendelian randomization studies

BMC Oral Health
Background Periodontitis has increasingly been recognized for its impact on systemic health. Mendelian Randomization (MR), an emerging causal inference method, effectively overcomes confounding biases in observational studies.
Yanghao Zhao, Churen Zhang, Xiaochi Chang, Jie Zhang, Chang Shu, Cheng Lin, Jianxia Hou   +6 more
doaj   +1 more source

Exploring causal correlations between oily fish intake and multiple sclerosis: A two-sample Mendelian randomization study. [PDF]

Asia Pac J Clin Nutr
Chang S, Shi K, Zhang M.
europepmc   +1 more source

Lost in the System: The Labyrinth of Rare Disease Diagnosis

European Medical Journal
Peter Fish
doaj   +1 more source