Results 71 to 80 of about 236,698 (345)

An alternative to Kitcher's theory of conceptual progress and his account of the change of the gene concept [PDF]

, 2004
The present paper discusses Kitcher’s framework for studying conceptual change and progress. Kitcher’s core notion of reference potential is hard to apply to concrete cases.
Brigandt, Ingo
core   +1 more source

Dairy consumption and cardiometabolic diseases: systematic review and updated meta-analyses of prospective cohort studies [PDF]

, 2018
Purpose of Review Dairy products contain both beneficial and harmful nutrients in relation to cardiometabolic diseases. Here, we provide the latest scientific evidence regarding the relationship between dairy products and cardiometabolic diseases by ...
A Hruby, A Lamri, A Tremblay, A Tremblay, AG Pittas, B Haring, B Lamarche, BJ Fuhrman, D Aune, D Gao, D Hu, D Kromhout, D Mozaffarian, D Mozaffarian, Daniel Lisko, DD Alexander, DI Givens, Doreen Gille, E Yu, EM Brouwer-Brolsma, F Rosqvist, FP Hartwig, G Buckland, GC Chen, Global Burden of Disease Risk Factors Collaborators, Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration, GW Dalmeijer, HEK Virtanen, HK Bergholdt, HK Bergholdt, HK Choi, I Sluijs, J Bodner-Montville, J Goede de, J Praagman, J Praagman, JA Nettleton, Jing Guo, JJ Dinicolantonio, JM Geleijnse, JP Drouin-Chartier, JP Drouin-Chartier, JP Higgins, JR Benatar, K Ge, KM Turner, L Brink, L Gijsbers, L Pimpin, L Schwingshackl, LA Mierlo van, LET Vissers, LM O'Connor, LQ Qin, M Chen, M Ding, M Kratz, M Talaei, M Talaei, M Talaei, M Talaei, MA Aerde van, MC Oliveira Otto de, ME Labonte, Mendelian Randomization of Dairy Consumption Working Group, MU Jakobsen, N Moslehi, NM Grantham, P Elwood, PC Elwood, Q Liu, Q Yang, R Villegas, S Greenland, S Parvez, Shuang Tian, SR Bauer, SS Lim, SS Soedamah-Muthu, SS Soedamah-Muthu, U Ericson, V Dilis, X Tong   +82 more
core   +3 more sources

Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism

Advanced Science, EarlyView.
By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini, Sabrina Mechaussier, Carolina Campos Pina, Monica Morais, Olivier Postal, Philippe Jean, Typhaine Dupont, Amrit Singh‐Estivalet, Shéhanie Udugampolage, Cyril Scandola, Elisabeth Verpy, Baptiste Libé‐Philippot, Talya C. Inbar, Joanna Schwenkgrub, Carla Maria Barbosa Spinola, Raphaël Etournay, Aziz El‐Amraoui, Brice Bathellier, Adeline Mallet, Sedigheh Delmaghani, Fabrice Giraudet, Christine Petit, Boris Gourévitch, Paul Avan, Nicolas Michalski   +24 more
wiley   +1 more source

Extending Models Via Gradient Boosting: An Application to Mendelian Models [PDF]

arXiv, 2021
Improving existing widely-adopted prediction models is often a more efficient and robust way towards progress than training new models from scratch. Existing models may (a) incorporate complex mechanistic knowledge, (b) leverage proprietary information and, (c) have surmounted barriers to adoption.
arxiv  

Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score [PDF]

, 2019
Mendelian randomization (MR) is a method of exploiting genetic variation to unbiasedly estimate a causal effect in presence of unmeasured confounding. MR is being widely used in epidemiology and other related areas of population science.
Bowden, Jack, Hemani, Gibran, Small, Dylan S., Wang, Jingshu, Zhao, Qingyuan   +4 more
core   +1 more source

Assumptions of IV Methods for Observational Epidemiology

, 2010
Instrumental variable (IV) methods are becoming increasingly popular as they seem to offer the only viable way to overcome the problem of unobserved confounding in observational studies.
Didelez, Vanessa, Meng, Sha, Sheehan, Nuala A.   +2 more
core   +1 more source

The Mendelian Inheritance of Mutations [PDF]

Science, 1908
n ...
openaire   +4 more sources

Mechanisms of Mendelian dominance [PDF]

Clinical Genetics, 2017
Genetic dominance has long been considered as a qualitative reflection of interallelic interactions. Dominance arises from many multiple sources whose unifying theme is the existence of non‐linear relationships between the genotypic and phenotypic values.
Sandrine Caburet, Sandrine Caburet, James A. Birchler, Reiner A. Veitia, Reiner A. Veitia   +4 more
openaire   +3 more sources

The GhWL1‐GhH1‐GhGA2OX1 Transcriptional Module Regulates Cotton Leaf Morphology

Advanced Science, EarlyView.
This study identified GhWL1 as a key gene involved in regulating leaf development through analysis of a T‐DNA insertion mutant. The GhWL1‐GhH1 complex is shown to positively regulate GhGA2OX1 by directly binding to its promoter, thereby establishing the GhWL1‐GhH1‐GhGA2OX1 module as a critical pathway in leaf development.
Jingjing Zhan, Xiaoshuang Zhang, Ye Wang, Hang Zhao, Yu Chu, Peng Wang, Yanli Chen, Xi Wei, Wenqiang Qin, Menghan Liu, Jie Kong, Fuguang Li, Xiaoyang Ge   +12 more
wiley   +1 more source

A cyclical switch of gametogenic pathways in hybrids depends on the ploidy level

Communications Biology
The cellular and molecular mechanisms governing sexual reproduction are conserved across eukaryotes. Nevertheless, hybridization can disrupt these mechanisms, leading to asexual reproduction, often accompanied by polyploidy. In this study, we investigate
Dmitrij Dedukh, Anatolie Marta, Ra-Yeon Myung, Myeong-Hun Ko, Da-Song Choi, Yong-Jin Won, Karel Janko   +6 more
doaj   +1 more source