Results 121 to 130 of about 60,478 (247)

A century of theories of balancing selection

open access: yesBiological Reviews, EarlyView.
ABSTRACT Traits that affect organismal fitness are often highly genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that nature – after all – ‘selects’ the best genotypes at the expense of those that fall short.
Filip Ruzicka   +10 more
wiley   +1 more source

Periodontitis and atherosclerotic cardiovascular disease: A critical appraisal

open access: yesPeriodontology 2000, EarlyView., 2023
Abstract In spite of intensive research efforts driving spectacular advances in terms of prevention and treatments, cardiovascular diseases (CVDs) remain a leading health burden, accounting for 32% of all deaths (World Health Organization. “Cardiovascular Diseases (CVDs).” WHO, February 1, 2017, https://www.who.int/news‐room/fact‐sheets/detail ...
Maria Clotilde Carra   +3 more
wiley   +1 more source

Spatial Location of SPP1+TAMs and Mutually Exclusive Subsets Based on Single‐Cell and Transcriptome Data

open access: yesCancer Science, EarlyView.
This study indicates that SPP1, as an important regulator of tumor progression, is upregulated in various tumors and has been associated with a poor prognosis. SPP1+M2 has a unique spatial location at the forefront of tumor invasion and metastasis, thereby promoting tumor progression. MARCO+M2, which forms a mutually exclusive relationship with SPP1+M2,
Xuan Luo   +15 more
wiley   +1 more source

Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity

open access: yesPeriodontology 2000, EarlyView., 2023
Abstract Noncommunicable diseases (NCDs) are multifactorial, long‐term, chronic conditions that represent a burden to health‐care systems worldwide as they can only be controlled rather than cured; hence, they require long‐term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is ...
Crystal Marruganti   +2 more
wiley   +1 more source

Effect Modification by Cofactors in the Impact of Body Mass Index Change on the Risk of Lung Cancer

open access: yesCancer Science, EarlyView.
Persistent overweight or obesity, and BMI gain from normal to overweight or obesity, were consistently associated with reduced lung cancer risk, with stronger associations among men and ever smokers. Persistent underweight and BMI loss were associated with increased lung cancer risk, particularly in men. The protective effect of obesity and BMI gain is
Su Youn Nam, Junwoo Jo, Sun Ha Choi
wiley   +1 more source

Disentangling the relationship between glucose, insulin and brain health: A UK Biobank study

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Background Glycaemic traits are associated with poorer brain health and dementia risk. Recent advances in genetic instruments for specific glycaemic markers enable an in‐depth investigation of the likely nature of associations and underlying mechanisms between diabetes‐related mechanisms and brain health and dementia.
Andrew C. Mason   +7 more
wiley   +1 more source

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