Results 121 to 130 of about 51,589 (295)

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

From multi‐omics to precision medicine in intracranial aneurysm: Biomarker discovery and multimodal integration

Interdisciplinary Medicine, EarlyView.
This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang, Yufei Yang, Bingxu Chen, Yanmeng Zhao, Haitao Sun   +4 more
wiley   +1 more source

A genetic instrument for Mendelian randomization of fibrinogen [PDF]

, 2012
Gie Ken‐Dror, Steve E. Humphries, Meena Kumari, Mika Kivimäki, Fotios Drenos   +4 more
openalex   +1 more source

Impact of placental and peripheral blood DNA methylation on celiac disease susceptibility

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Several studies suggest that the first immunogenic insult in celiac disease (CeD) could occur during fetal development. The placenta is a key organ that could link the environment with the genome and future outcomes, including CeD.
Alba Hernangomez‐Laderas, Ariadna Cilleros‐Portet, Mikel de la Peña‐Sanz, Sergi Marí, Corina Lesseur, Itziar González‐Moro, Bárbara P. González‐García, Jia Chen, Iraia García‐Santisteban, Carmen J. Marsit, Jose Ramon Bilbao, Nora Fernandez‐Jimenez   +11 more
wiley   +1 more source

E-Values for Mendelian Randomization

Epidemiology, 2020
Tyler J. VanderWeele, Sonja A. Swanson
openaire   +4 more sources

Editorial: Mendelian Randomization: Approach and Applications [PDF]

Frontiers in Genetics, 2021
Yao-Zhong Liu, Lei Zhang, Guo-Liang Wu
openaire   +3 more sources

Causal Link and Shared Biomarkers Between Rheumatoid Arthritis and Idiopathic Pulmonary Fibrosis

Med Research, EarlyView.
ABSTRACT This study investigates the causal relationship between rheumatoid arthritis (RA) and idiopathic pulmonary fibrosis (IPF), aiming to identify shared biomarkers between the two conditions. Utilizing bidirectional Mendelian randomization (MR), we assessed causality by analyzing genome‐wide association study (GWAS) data from European cohorts ...
Xixi Pan, Chunhui Jiang, Jiani Chen, Tong Sun, Xianwei Wang, Jiaxi Chen   +5 more
wiley   +1 more source

Schizophrenia and Types of Stroke: A Mendelian Randomization Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Previous studies suggest an association between schizophrenia and stroke, but no studies have investigated stroke subtypes. We examined potential causal associations between schizophrenia and a range of atherosclerotic, embolic, and ...
Shinya Nakada, Frederick K. Ho, Carlos Celis‐Morales, Jill P. Pell   +3 more
doaj   +1 more source

Prenatal alcohol exposure and childhood atopic disease: A Mendelian randomization approach [PDF]

, 2013
Seif O. Shaheen, Clare Rutterford, Luisa Zuccolo, Susan M. Ring, George Davey Smith, John W. Holloway, A. John Henderson   +6 more
openalex   +1 more source

Genetics Influences Telomere Length in Parkinson's Disease: A Study in Monozygotic Discordant Twins

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) results from complex interactions among environmental, genetic, and aging factors. Telomeres, which ensure chromosome stability, naturally shorten with cell division, contributing to aging and cellular senescence.
Letizia Straniero, Valeria Rimoldi, Emanuele Cereda, Giulia Soldà, Daniela Calandrella, Stefano Duga, Samanta Mazzetti, Graziella Cappelletti, Ioannis U. Isaias, Gianni Pezzoli, Rosanna Asselta   +10 more
wiley   +1 more source