Results 121 to 130 of about 4,310,301 (302)

The relationship between inflammatory factors and heart failure: evidence based on bidirectional Mendelian randomization analysis

Frontiers in Cardiovascular Medicine
ObjectiveInflammatory factors play a crucial role in the onset and progression of heart failure. To further explore the causal relationship between inflammatory factors and heart failure, we employed bidirectional Mendelian randomization analysis to ...
Xuanchun Huang, Lanshuo Hu, Jun Li, Shiyi Tao, Tiantian Xue   +4 more
doaj   +1 more source

Allium Vegetables Intake and Digestive System Cancer Risk: A Study Based on Mendelian Randomization, Network Pharmacology and Molecular Docking [PDF]

arXiv
Background: Allium vegetables (garlic and onion) are one of the flavorings in people's daily diets. Observational studies suggest that intake of allium vegetables may be correlated with a lower incidence of digestive system cancers. However, the existence of a causal relationship is still controversial due to confounding factors and reverse causation ...
arxiv  

Commentary: Fibrinogen and coronary heart disease—test of causality by ‘Mendelian’ randomization by Keavney et al. [PDF]

, 2006
Tom Meade, Steve E. Humphries, Bianca De Stavola   +2 more
openalex   +1 more source

Assessment of relationships between epigenetic age acceleration and multiple sclerosis: a bidirectional mendelian randomization study

Epigenetics & Chromatin
Background The DNA methylation-based epigenetic clocks are increasingly recognized for their precision in predicting aging and its health implications. Although prior research has identified connections between accelerated epigenetic aging and multiple ...
Hongwei Liu, Hanqing Zhang, Zhaoxu Yin, Miaomiao Hou   +3 more
doaj   +1 more source

Lactase Persistence and Bitter Taste Response: Instrumental Variables and Mendelian Randomization in Epidemiologic Studies of Dietary Factors and Cancer Risk [PDF]

, 2007
Carlotta Sacerdote, Simonetta Guarrera, George Davey Smith, Sara Grioni, Vittorio Krogh, Giovanna Masala, Amalia Mattiello, Domenico Palli, Salvatore Panico, ­Rosario ­Tumino, Fabrizio Veglia, Giuseppe Matullo, P. Vineis   +12 more
openalex   +1 more source

Effects of fourteen essential minerals and vitamins on acute and chronic tubulointerstitial nephritis: a multivariate Mendelian randomization study

Hereditas
Objective To investigate the causal relationship between minerals and vitamins and acute and chronic tubulointerstitial nephritis by Mendelian randomization.
Xiaotan Pan, Zhiyan Guo, Yin Zheng, Cheng Su, Jiabo Chen   +4 more
doaj   +1 more source

Genetic association of lipids and lipid-lowering drug target genes with Endometrial carcinoma: a drug target Mendelian randomization study

Frontiers in Endocrinology
BackgroundAberrant lipid metabolism is intricately linked to the development of endometrial cancer, and statin lipid-lowering medications are regarded as promising adjunctive therapies for future management of this malignancy.
Zhehan Yang, Zhehan Yang, Zhehan Yang, Junpan Chen, Minghao Wen, Jiayuan Lei, Ming Zeng, Ming Zeng, Sichen Li, Sichen Li, Yao Long, Yao Long, Zhiyi Zhou, Chunyan Wang, Chunyan Wang   +14 more
doaj   +1 more source

Capitalizing on Mendelian randomization to assess the effects of treatments [PDF]

, 2007
George Davey Smith
openalex   +1 more source

Revealing the link between gut microbiota and brain tumor risk: a new perspective from Mendelian randomization

Frontiers in Cellular and Infection Microbiology
BackgroundRecent studies have shown that gut microbiota may be related to the occurrence of brain tumors, but direct evidence is lacking. This study used the Mendelian randomization study (MR) method to explore the potential causal link between gut ...
Jianyu Yang, Jietao Lu, Yuhan Dong, Youdong Wei, Michael Christian, Junmeng Huang, Haiyan Kuang, Du Cao   +7 more
doaj   +1 more source

Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects

American Journal of Epidemiology, 2015
A conventional Mendelian randomization analysis assesses the causal effect of a risk factor on an outcome by using genetic variants that are solely associated with the risk factor of interest as instrumental variables. However, in some cases, such as the
S. Burgess, S. Thompson
semanticscholar   +1 more source