Results 131 to 140 of about 51,589 (295)

Therapeutic targets for muscle weakness in older adults: proteome-wide Mendelian randomization and colocalization analyses

The Journal of Nutrition, Health and Aging
Background: Recent research highlights the importance of muscular strength as a key factor in physical fitness, a strong indicator of overall mortality risk, and a vital target for preventing chronic diseases.
Shuai-Kang Wang, Qi-Jun Wang, Xuan Zhao, Peng Wang, Xiang-Yu Li, Wei Wang, Shi-Bao Lu   +6 more
doaj  

Proteome‐Wide Mendelian Randomization Identifies Therapeutic Targets for Abdominal Aortic Aneurysm

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The proteome is a key source of therapeutic targets. We conducted a comprehensive Mendelian randomization analysis across the proteome to identify potential protein markers and therapeutic targets for abdominal aortic aneurysm (AAA).
Ka Zhang, Yuan Liu, Aiqin Mao, Changzhu Li, Li Geng, Hao Kan   +5 more
doaj   +1 more source

The causal effect of red blood cell folate on genome-wide methylation in cord blood: a Mendelian randomization approach [PDF]

, 2013
Alexandra M. Binder, Karin B. Michels
openalex   +1 more source

Genetic and environmental contributions to the associations between midlife personality and late‐life metabolic health

Obesity, EarlyView.
Abstract Objective Personality traits such as conscientiousness and emotional stability are consistently linked with better metabolic health, but there is limited evidence on the etiology of these associations and their robustness across the life‐span. Methods Therefore, we estimated phenotypic, genetic, and unique environmental associations of traits ...
Colin D. Freilich, Jacob J. Kunkel, Keely A. Dugan, Elise J. Vomacka, Adolfo G. Cuevas, Kristian Markon, Matt McGue, Glenn I. Roisman, Robert F. Krueger   +8 more
wiley   +1 more source

Gut microbiota in combination with blood metabolites reveals characteristics of the disease cluster of coronary artery disease and cognitive impairment: a Mendelian randomization study

Frontiers in Immunology
BackgroundThe coexistence of coronary artery disease (CAD) and cognitive impairment has become a common clinical phenomenon. However, there is currently limited research on the etiology of this disease cluster, discovery of biomarkers, and identification
Shihan Xu, Shihan Xu, Shihan Xu, Yanfei Liu, Yanfei Liu, Yanfei Liu, Qing Wang, Qing Wang, Qing Wang, Fenglan Liu, Yanfang Xian, Fengqin Xu, Fengqin Xu, Fengqin Xu, Fengqin Xu, Yue Liu, Yue Liu   +16 more
doaj   +1 more source

Grip strength: are some adiposity phenotypes more detrimental than others? A Mendelian randomization study

Obesity, EarlyView.
Abstract Objective Our objective was to investigate causal associations of adiposity in different locations and metabolically favorable and unfavorable adiposity (MetFA and MetUFA, respectively) with grip strength. Methods Observational cross‐sectional and Mendelian randomization (MR) (sex combined and stratified) analysis within UK Biobank (N ≤ 340 ...
Amy E. Taylor, John Vincent, Dylan M. Williams, Rachel Cooper, Snehal M. Pinto Pereira   +4 more
wiley   +1 more source

Gut microbiota influences colorectal cancer through immune cell interactions: a Mendelian randomization study

Discover Oncology
Background Colorectal cancer (CRC) is the most prevalent malignant tumor of the digestive system globally, posing a significant threat to human health and quality of life.
Linyi Zheng, Yuqiang Li, Cenap Güngör, Heming Ge   +3 more
doaj   +1 more source

Exploring the causal links between cigarette smoking, alcohol consumption, and aneurysmal subarachnoid hemorrhage: a two-sample Mendelian randomization analysis

Frontiers in Nutrition
BackgroundAneurysmal subarachnoid hemorrhage (aSAH) represents a critical health concern characterized by elevated mortality and morbidity rates. Although both genetic predisposition and lifestyle choices influence aSAH susceptibility, understanding the ...
Heng Lin, Yanqing Yin, Jie Li, Siwei Liu, Xiaoao Long, Zhuangbin Liao   +5 more
doaj   +1 more source

Evolutionary rescue in a mixed beech–fir forest: insights from a quantitative‐genetics approach in a process‐based model

Oikos, EarlyView.
Questions have been raised about the ability of long‐lived organisms, such as trees, to adapt to rapid climate change, and to what extent forest management actions influence the evolutionary responses of tree species. Given the life history of trees and the time scales involved, these questions are often addressed through modeling approaches. Yet, most
Louis Devresse, Freya Way, Tanguy Postic, François de Coligny, Xavier Morin   +4 more
wiley   +1 more source

Low Nonfasting Triglycerides and Reduced All-Cause Mortality: A Mendelian Randomization Study [PDF]

, 2014
Mette Thomsen, Anette Varbo, Anne Tybjærg‐Hansen, Børge G. Nordestgaard   +3 more
openalex   +1 more source