Results 131 to 140 of about 95,337 (328)

Commentary: Mendelian randomization, 18 years on [PDF]

International Journal of Epidemiology, 2004
I have no notes left regarding writing ‘Apolipoprotein E isoforms, serum cholesterol, and cancer’,1 but I think I thought it up in Hawaii. I passed through Hawaii on my way to the US from Melbourne, where I had given a talk on diet, low cholesterol, and cancer at the 7th International Atherosclerosis Symposium in October 1985.
openaire   +2 more sources

Genetic and Environmental Associations Among Pain, Sleep Disturbances, and Substance Use Intent in Early Adolescence

Journal of Adolescence, EarlyView.
ABSTRACT Purpose Pain, sleep disturbances, and substance use are common in adolescence, with research indicating that genetic and environmental factors account for variation in each of these behavioral and health outcomes. Moreover, pain, sleep disturbances, and substance use often co‐occur during adolescence. However, research has not examined whether
Kit K. Elam, Angel Trevino, Jodi Kutzner, Jinni Su, Patrick D. Quinn   +4 more
wiley   +1 more source

The Role of Viral and Bacterial Infections in the Etiology of Behçet's Disease

Journal of Clinical Laboratory Analysis, EarlyView.
Bacterial and viral pathogens may play a key role in Behçet's disease (BD) pathogenesis by triggering autoimmunity, molecular mimicry, or microbiome disruption. These infectious agents could initiate inflammatory pathways, contributing to BD's diverse clinical manifestations.
Mohsen Moghoofei, Hamid Pajavand, Razieh Shahbazi, Marzieh Rezaei, Elahe Taki   +4 more
wiley   +1 more source

Genetic Evidence Implicating Gut Microbiota and Circulating Cytokines in Sjögren's Syndrome

Journal of Clinical Laboratory Analysis, EarlyView.
Complex bidirectional causal relationships were found between gut microbiota abundance and Sjögren's syndrome (SS). Five circulating cytokines were shown to potentially affect SS, including MIG, IL‐5, IL‐1RA, IL‐2RA, and SCGF‐β, and SS was found to increase levels of two circulating cytokines, IL‐1β and IL‐5.
Yuchen Cai, Tianyi Zhou, Wenjun Shi, Xia Ding, Xueyao Cai, Li Yu   +5 more
wiley   +1 more source

The relationship between inflammatory factors and heart failure: evidence based on bidirectional Mendelian randomization analysis

Frontiers in Cardiovascular Medicine
ObjectiveInflammatory factors play a crucial role in the onset and progression of heart failure. To further explore the causal relationship between inflammatory factors and heart failure, we employed bidirectional Mendelian randomization analysis to ...
Xuanchun Huang, Lanshuo Hu, Jun Li, Shiyi Tao, Tiantian Xue   +4 more
doaj   +1 more source

Causal effects of B vitamins and homocysteine on obesity and musculoskeletal diseases: A Mendelian randomization study

, 2022
Liwan Fu, Yuquan Wang, Yue‐Qing Hu
openalex   +1 more source

Causal Effect of Relative Carbohydrate Intake on Hypertension through Psychological Well-Being and Adiposity: A Mendelian Randomization Study [PDF]

, 2023
Chaojie Ye, Lijie Kong, Yiying Wang, Chun Dou, Min Xu, Jie Zheng, Ruizhi Zheng, Yu Xu, Mian Li, Zhiyun Zhao, Jieli Lu, Yuhong Chen, Weiqing Wang, Yufang Bi, Tiange Wang, Guang Ning   +15 more
openalex   +1 more source

Assessment of relationships between epigenetic age acceleration and multiple sclerosis: a bidirectional mendelian randomization study

Epigenetics & Chromatin
Background The DNA methylation-based epigenetic clocks are increasingly recognized for their precision in predicting aging and its health implications. Although prior research has identified connections between accelerated epigenetic aging and multiple ...
Hongwei Liu, Hanqing Zhang, Zhaoxu Yin, Miaomiao Hou   +3 more
doaj   +1 more source

Evaluating the Causal Link Between Malaria Infection and Endemic Burkitt Lymphoma in Northern Uganda: A Mendelian Randomization Study [PDF]

, 2017
Ismail D. Legason, Ruth M. Pfeiffer, Krizia-Ivana Udquim, Andrew W. Bergen, Mateus H. Gouveia, Samuel Kirimunda, Isaac Otim, Eric Karlins, Patrick Kerchan, Hadijah Nabalende, Ariunaa Bayanjargal, Benjamin Emmanuel, Paul Kagwa, Ambrose Talisuna, Kishor Bhatia, Meredith Yeager, Robert J. Biggar, Leona W. Ayers, Steven J. Reynolds, James J. Goedert, Martin D. Ogwang, Joseph F. Fraumeni, Ludmila Prokunina‐Olsson, Sam M. Mbulaiteye   +23 more
openalex   +1 more source

Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: a within-family Mendelian randomization study [PDF]

, 2021
Amanda Hughes, Eleanor Sanderson, Tim Morris, Ziada Ayorech, Martin Tesli, Helga Ask, Ted Reichborn‐Kjennerud, Ole A. Andreassen, Per Magnus, Øyvind Helgeland, Stefan Johansson, Pål R. Njølstad, George Davey Smith, Alexandra Havdahl, Laura D. Howe, Neil M Davies   +15 more
openalex   +1 more source