Results 241 to 250 of about 1,141,533 (358)

Assessing the protective role of allergic disease in gastrointestinal tract cancers using Mendelian randomization analysis

, 2020
Shuai Yuan, Mathew Vithayathil, Siddhartha Kar, Paul Carter, Amy M. Mason, Shao‐Hua Xie, Stephen Burgess, Susanna C. Larsson   +7 more
openalex   +1 more source

Serum Phosphate, BMI, and Body Composition of Middle-Aged and Older Adults: A Cross-Sectional Association Analysis and Bidirectional Mendelian Randomization Study

, 2021
Ariadne Bosman, Natalia Campos‐Obando, Carolina Medina‐Gómez, Trudy Voortman, André G. Uitterlinden, M. Carola Zillikens   +5 more
openalex   +1 more source

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 channels to control artery tone and capillary diameter

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye, Claire Pearson, Tibyan Babiker, Emilio Agostinelli, Rumaitha Al‐Hosni, Paolo Tammaro   +5 more
wiley   +1 more source

Association between 1400 metabolites and IgA nephropathy: A Mendelian randomization analysis. [PDF]

Medicine (Baltimore)
Wang C, Li Y, Zhong L, Sun N, Luo D, Xu Y, Qi A.   +6 more
europepmc   +1 more source

Targeting FABP4 to Inhibit AGEs‐RAGE/NF‐κB Signalling Effectively Ameliorates Nucleus Pulposus Dysfunction and Angiogenesis in Obesity‐Related Intervertebral Disc Degeneration

Cell Proliferation, EarlyView.
Obesity promotes the progression of intervertebral disc degeneration (IVDD) through the mTORC1/FABP4 axis. Targeting FABP4 effectively ameliorates nucleus pulposus dysfunction and angiogenesis in obesity‐related IVDD. ABSTRACT Intervertebral disc degeneration (IVDD) is a primary contributor to low back pain, posing significant social and economic ...
Lin Han, Fudong Li, Huiqiao Wu, Weiheng Wang, Peiwen Chen, Weicheng Xia, Yang Liu, Kaiqiang Sun, Wenbo Lin   +8 more
wiley   +1 more source

Mendelian randomization analysis of C-reactive protein on septic arthritis risk. [PDF]

Medicine (Baltimore)
Lei H, Tian P, Chen J, Chen S, Lai G, Zhou L.   +5 more
europepmc   +1 more source

Observational and Causal Association of Blood Vitamin D with Gut Microbiota: Evidence from a Prospective Cohort and Mendelian Randomization Analysis

, 2020
Ju‐Sheng Zheng, Fengzhe Xu, Yu‐Ming Chen   +2 more
openalex   +1 more source

Why, how and in whom should we measure levels of lipoprotein(a): A review of the latest evidence and clinical implications

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Lipoprotein(a) [Lp(a)] is a genetically determined, causal risk factor for atherosclerotic cardiovascular disease (ASCVD) and calcific aortic valve disease (CAVD). Despite robust evidence from epidemiological and genetic studies, Lp(a) remains underrecognised in clinical practice due to challenges in measurement, lack of guideline familiarity ...
Alexander C. Razavi, Harpreet S. Bhatia, Roger S. Blumenthal, Michael D. Shapiro, Anurag Mehta   +4 more
wiley   +1 more source

Mendelian Randomization Analysis Reveals Causal Effects of Circulating Metabolites on Hyperaldosteronism. [PDF]

Food Sci Nutr
Zhao C, Chen F, Peng L, Li Q, Pang Y, Yue C.   +5 more
europepmc   +1 more source

Phosphate, BMI and body composition in the Rotterdam Study: Mendelian randomization analysis suggests a causal effect of BMI on serum phosphate level

, 2020
Ariadne Bosman, Natalia Campos‐Obando, Trudy Voortman, Arfan M. Ikram, Bram C. J. van der Eerden, André G. Uitterlinden, M. Carola Zillikens   +6 more
openalex   +1 more source