Results 31 to 40 of about 1,141,533 (358)

Modifiable lifestyle factors and risk of stroke: a Mendelian randomization analysis [PDF]

Stroke, 2020
ABSTRACTAimsAssessing whether modifiable risk factors are causally associated with reduced stroke risk is important in planning public health measures, but determining causality can be difficult in epidemiological data. Leveraging large-scale genetic data in a technique known as Mendelian randomisation, we aimed to determine whether modifiable ...
Harshfield, Eric L, Georgakis, Marios K, Malik, Rainer, Dichgans, Martin, Markus, Hugh S   +4 more
openaire   +7 more sources

Effects of epigenetic age acceleration on kidney function: a Mendelian randomization study

Clinical Epigenetics, 2023
Background Previous studies have reported cross-sectional associations between measures of epigenetic age acceleration (EAA) and kidney function phenotypes. However, the temporal and potentially causal relationships between these variables remain unclear.
Yang Pan, Xiao Sun, Zhijie Huang, Ruiyuan Zhang, Changwei Li, Amanda H. Anderson, James P. Lash, Tanika N. Kelly   +7 more
doaj   +1 more source

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

Genetic Epidemiology, 2013
Genome‐wide association studies, which typically report regression coefficients summarizing the associations of many genetic variants with various traits, are potentially a powerful source of data for Mendelian randomization investigations.
S. Burgess, A. Butterworth, S. Thompson
semanticscholar   +1 more source

C-reactive protein and cancer risk: a pan-cancer study of prospective cohort and Mendelian randomization analysis

BMC Medicine, 2022
Although observational studies have reported associations between serum C-reactive protein (CRP) concentration and risks of lung, breast, and colorectal cancer, inconsistent or absent evidences were showed for other cancers.
Meng Zhu, Zhimin Ma, Xu Zhang, D. Hang, R. Yin, Jifeng Feng, Lin Xu, Hongbing Shen   +7 more
semanticscholar   +1 more source

Graphical analysis for phenome-wide causal discovery in genotyped population-scale biobanks

Nature Communications, 2021
Mendelian randomization is a popular method to detect causal relationships between traits, but can be confounded by instances of horizontal pleiotropy. Here, the authors present a Mendelian randomization workflow which includes causal discovery analysis ...
David Amar, Nasa Sinnott-Armstrong, Euan A. Ashley, Manuel A. Rivas   +3 more
doaj   +1 more source

Homocysteine and small vessel stroke: A mendelian randomization analysis [PDF]

Annals of Neurology, 2019
ObjectiveTrials of B vitamin therapy to lower blood total homocysteine (tHcy) levels for prevention of stroke are inconclusive. Secondary analyses of trial data and epidemiological studies suggest that tHcy levels may be particularly associated with small vessel stroke (SVS).
Susanna C. Larsson, Susanna C. Larsson, Matthew Traylor, Hugh S. Markus   +3 more
openaire   +4 more sources

Triglyceride-glucose index and the risk of heart failure: Evidence from two large cohorts and a mendelian randomization analysis

Cardiovascular Diabetology, 2022
Background The relationship between triglyceride-glucose (TyG) index, an emerging marker of insulin resistance, and the risk of incident heart failure (HF) was unclear. This study thus aimed to investigate this relationship.
Xiujun Li, J. Chan, B. Guan, S. Peng, X. Wu, J. Zhou, J. Hui, Y. H. A. Lee, D. Satti, S. Tsang, S. Wu, S. Chen, G. Tse, S. Liu   +13 more
semanticscholar   +1 more source

Mendelian Randomization Analysis in Observational Epidemiology

Journal of Lipid and Atherosclerosis, 2019
Mendelian randomization (MR) in epidemiology is the use of genetic variants as instrumental variables (IVs) in non-experimental design to make causality of a modifiable exposure on an outcome or disease. It assesses the causal effect between risk factor and a clinical outcome.
Kwan Lee, Chi-Yeon Lim
openaire   +3 more sources

Causal linkage of tobacco smoking with ageing: Mendelian randomization analysis towards telomere attrition and sarcopenia

Journal of Cachexia, Sarcopenia and Muscle, 2023
Ageing traits and frailty are important health issues in modern medicine. Evidence supporting the causal effects of tobacco smoking on various ageing traits is required.
Sehoon Park, S. Kim, S. Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Hyun Kwon, S. Han, Hajeong Lee, J. P. Lee, K. Joo, C. Lim, Y. S. Kim, D. K. Kim   +13 more
semanticscholar   +1 more source

Body Shape and Alzheimer’s Disease: A Mendelian Randomization Analysis [PDF]

Frontiers in Neuroscience, 2019
Obesity has been reported to be related to memory impairment and decline in cognitive function, possibly further leading to the development of Alzheimer's disease (AD). However, observational studies revealed both negative and positive associations between body shape (BS) and AD, thereby making it difficult to confirm causality due to residual ...
Maigeng Zhou, Yuchang Zhou, Xiubin Sun
openaire   +4 more sources