Results 31 to 40 of about 72,268 (331)

Homocysteine and small vessel stroke: A mendelian randomization analysis [PDF]

Annals of Neurology, 2019
ObjectiveTrials of B vitamin therapy to lower blood total homocysteine (tHcy) levels for prevention of stroke are inconclusive. Secondary analyses of trial data and epidemiological studies suggest that tHcy levels may be particularly associated with small vessel stroke (SVS).
Larsson, Susanna C., Traylor, Matthew, Markus, Hugh S.   +2 more
openaire   +3 more sources

Circulating Selenium and Prostate Cancer Risk: A Mendelian Randomization Analysis [PDF]

JNCI: Journal of the National Cancer Institute, 2017
AbstractIn the Selenium and Vitamin E Cancer Prevention Trial (SELECT), selenium supplementation (causing a median 114 μg/L increase in circulating selenium) did not lower overall prostate cancer risk, but increased risk of high-grade prostate cancer and type 2 diabetes.
Yarmolinsky, James, Bonilla, Carolina, Haycock, Philip, Langdon, Ryan, Lotta, Luca, Langenberg, Claudia, Relton, Caroline, Lewis, Sarah, Evans, David, Smith, George Davey, Martin, Richard, Batra, Jyotsna, Clements, Judith, other, and   +13 more
openaire   +4 more sources

Statistical methods for Mendelian randomization in genome-wide association studies: A review

Computational and Structural Biotechnology Journal, 2022
Genome-wide association studies have yielded thousands of associations for many common diseases and disease-related complex traits. The identified associations made it possible to identify the causal risk factors underlying diseases and investigate the ...
Frederick J. Boehm, Xiang Zhou
doaj   +1 more source

Serum resistin is causally related to mortality risk in patients with type 2 diabetes: Preliminary evidences from genetic data [PDF]

, 2017
Resistin has been firmly associated with all-cause mortality. We investigated, whether, in patients with type 2 diabetes (T2D), this association is sustained by a cause-effect relationship.
Cignarelli, Mauro, Copetti, Massimiliano, De Bonis, Concetta, De Cosmo, Salvatore, Fontana, Andrea, Lamacchia, Olga, Menzaghi, Claudia, Moreno, Lorena Ortega, Salvemini, Lucia, Trischitta, Vincenzo   +9 more
core   +1 more source

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. [PDF]

, 2018
Lipoprotein(a), Lp(a), is a modified low-density lipoprotein particle that contains apolipoprotein(a), encoded by LPA, and is a highly heritable, causal risk factor for cardiovascular diseases that varies in concentrations across ancestries. Here, we use
Alver, Maris, Bloom, Jonathan, Budoff, Matthew, Chaffin, Mark, Correa, Adolfo, Cupples, L Adrienne, Daly, Mark J, Engreitz, Jesse, Ernst, Jason, Esko, Tonu, Fu, Mao, Ganna, Andrea, Handsaker, Robert E, Johnson, W Craig, Kathiresan, Sekar, Kellis, Manolis, Manichaikul, Ani, McCarroll, Steven, Metspalu, Andres, Mitchell, Braxton D, Natarajan, Pradeep, Neale, Benjamin M, NHLBI TOPMed Lipids Working Group, Peloso, Gina M, Post, Wendy, Poterba, Timothy, Rich, Stephen S, Ripatti, Samuli, Rotter, Jerome I, Ruotsalainen, Sanni, Ryan, Kathleen A, Salomaa, Veikko, Seed, Cotton, Surakka, Ida, Tsai, Michael, Vasan, Ramachandran S, Wilson, James G, Yang, Chaojie, Zekavat, Seyedeh M   +38 more
core   +1 more source

Variability in genes regulating vitamin D metabolism is associated with vitamin D levels in type 2 diabetes [PDF]

, 2018
Mortality rate is increased in type 2 diabetes (T2D). Low vitamin D levels are associated with increased mortality risk in T2D. In the general population, genetic variants affecting vitamin D metabolism (DHCR7 rs12785878, CYP2R1 rs10741657, GC rs4588 ...
Alessi, Elena, Bagella, FRANCESCO MARIA, Bailetti, Diego, Barchetta, Ilaria, Baroni Marco, Giorgio., Bertoccini, Laura, Buzzetti, Raffaella, Capoccia, Danila, Cavallo, Maria Gisella, Coccia, Federica, Conti, Francesco, Copetti, Massimiliano, Cossu, Efisio, D'Angelo, Paola, D'Onofrio, Luca, De Cosmo, Salvatore, Di Mauro, Lazzaro, Filardi, Tiziana, Gianluca, Margiotta, Giulia, Leanza, Incani, Michela, Leonetti, Frida, Maria Giovanna Scarale,, Morano, Susanna, Moretti, Chiara, Morviducci, Lelio, Napoli, Nicola, Pamela, Piscitelli, Pezzilli, Serena, Pibiri, Carlotta, Prudente, Sabrina, Pugliese, Giuseppe, Sentinelli, Federica, Silvia, Carletti, SUMMER Study in Diabetes Group (Summer,, Tavaglione, Federica, Trischitta, Vincenzo   +36 more
core   +1 more source

Genome-wide association study identifies common and low-frequency variants at the AMHgene locus that strongly predict serum AMH levels in males [PDF]

, 2016
Anti-Müllerian hormone (AMH) is an essential messenger of sexual differentiation in the foetus and is an emerging biomarker of postnatal reproductive function in females.
Day, Felix R., Lawlor, Debbie A., McMahon, George, Nelson, Scott M., Perry, John R.B., Ring, Susan M.   +5 more
core   +1 more source

Body Shape and Alzheimer’s Disease: A Mendelian Randomization Analysis [PDF]

Frontiers in Neuroscience, 2019
Obesity has been reported to be related to memory impairment and decline in cognitive function, possibly further leading to the development of Alzheimer's disease (AD). However, observational studies revealed both negative and positive associations between body shape (BS) and AD, thereby making it difficult to confirm causality due to residual ...
Yuchang Zhou, Xiubin Sun, Maigeng Zhou
openaire   +3 more sources

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

Dairy consumption and cardiometabolic diseases: systematic review and updated meta-analyses of prospective cohort studies [PDF]

, 2018
Purpose of Review Dairy products contain both beneficial and harmful nutrients in relation to cardiometabolic diseases. Here, we provide the latest scientific evidence regarding the relationship between dairy products and cardiometabolic diseases by ...
A Hruby, A Lamri, A Tremblay, A Tremblay, AG Pittas, B Haring, B Lamarche, BJ Fuhrman, D Aune, D Gao, D Hu, D Kromhout, D Mozaffarian, D Mozaffarian, Daniel Lisko, DD Alexander, DI Givens, Doreen Gille, E Yu, EM Brouwer-Brolsma, F Rosqvist, FP Hartwig, G Buckland, GC Chen, Global Burden of Disease Risk Factors Collaborators, Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration, GW Dalmeijer, HEK Virtanen, HK Bergholdt, HK Bergholdt, HK Choi, I Sluijs, J Bodner-Montville, J Goede de, J Praagman, J Praagman, JA Nettleton, Jing Guo, JJ Dinicolantonio, JM Geleijnse, JP Drouin-Chartier, JP Drouin-Chartier, JP Higgins, JR Benatar, K Ge, KM Turner, L Brink, L Gijsbers, L Pimpin, L Schwingshackl, LA Mierlo van, LET Vissers, LM O'Connor, LQ Qin, M Chen, M Ding, M Kratz, M Talaei, M Talaei, M Talaei, M Talaei, MA Aerde van, MC Oliveira Otto de, ME Labonte, Mendelian Randomization of Dairy Consumption Working Group, MU Jakobsen, N Moslehi, NM Grantham, P Elwood, PC Elwood, Q Liu, Q Yang, R Villegas, S Greenland, S Parvez, Shuang Tian, SR Bauer, SS Lim, SS Soedamah-Muthu, SS Soedamah-Muthu, U Ericson, V Dilis, X Tong   +82 more
core   +6 more sources