Results 41 to 50 of about 1,141,533 (358)
Modifiable pathways for longevity: A Mendelian randomization analysis
Clinical Nutrition, 2023 A variety of factors, including diet and lifestyle, obesity, physiology, metabolism, hormone levels, psychology, and inflammation, have been associated with longevity. The specific influences of these factors, however, are poorly understood. Here, possible causal relationships between putative modifiable risk factors and longevity are investigated.A ...
Xiaolin Ni +7 more
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Can we apply the Mendelian randomization methodology without considering epigenetic effects?
Emerging Themes in Epidemiology, 2009 Introduction Instrumental variable (IV) methods have been used in econometrics for several decades now, but have only recently been introduced into the epidemiologic research frameworks.
Karmaus Wilfried +2 more
doaj +1 more source
Digital Health, 2023 Objective Inconsistent results were reported on the association of physical activity with ovarian cancer. However, given the limitations of confounders and inverse causation, the validity of the association remained unclear. Therefore, we conducted a two-
Jing Wang +3 more
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Survivor bias in Mendelian randomization analysis
Biostatistics, 2017 Mendelian randomization studies employ genotypes as experimental handles to infer the effect of genetically modified exposures (e.g. vitamin D exposure) on disease outcomes (e.g. mortality). The statistical analysis of these studies makes use of the standard instrumental variables framework.
Stijn Vansteelandt +3 more
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Annals medicus, 2022 Purpose It has been found that childhood obesity (CO) may play an important role in the onset and progression of osteoarthritis (OA). Thus we conducted this mendelian randomisation analysis (MR) to evaluate the causal association between childhood ...
Ziqin Cao +4 more
semanticscholar +1 more source
Physical Activity, Sedentary Behavior, and Type 2 Diabetes: Mendelian Randomization Analysis
Journal of the Endocrine Society, 2023 Context The causality and pathways of the associations between physical activity and inactivity and the risk of type 2 diabetes remain inconclusive.
S. Yuan +6 more
semanticscholar +1 more source
Causal effects of gut microbiome on hypertension: a Mendelian randomization study
Frontiers in Microbiology, 2023 BackgroundPrevious observational studies have shown that there is an important relationship between gut microbiota and hypertension, we performed a two-sample Mendelian randomization analysis to examine whether the gut microbiota is causally related to ...
Gang He +4 more
doaj +1 more source
Constipation and cardiovascular disease: A two-sample Mendelian randomization analysis
Frontiers in Cardiovascular Medicine, 2023 Background Although several observational studies have suggested positive associations between constipation and cardiovascular disease (CVD), a solid causal association has not been demonstrated. Therefore, a two-sample Mendelian randomization (MR) study
Qichao Dong +5 more
semanticscholar +1 more source
Epilepsia Open, EarlyView., 2022 Abstract Rodent models of epilepsy remain the cornerstone of research into the mechanisms underlying genetic epilepsy. Reproducibility of experiments using these rodent models, occurring across a diversity of laboratories and commercial vendors, remains an issue impacting the cost‐effectiveness and scientific rigor of the studies performed.
Massimo Mantegazza +7 more
wiley +1 more source
Overview of Mendelian Randomization Analysis
Journal of Rheumatic Diseases, 2020 The inference of causality from observational evidence may be problematic, as observational studies frequently include confounding factors or reverse causation for the identification of associations between exposure and outcome. Thus, in observational studies, the association between a risk factor and a disease of interest may not be causal.
openaire +3 more sources