Results 51 to 60 of about 1,141,533 (358)

Mendelian randomization analysis revealed a gut microbiota–mammary axis in breast cancer

Frontiers in Microbiology, 2023
Background Observational epidemiological studies suggested an association between the gut microbiota and breast cancer, but it remains unclear whether the gut microbiota causally influences the risk of breast cancer.
Shuwan Zhang, Wenchuan Zhang, Haiyue Ren, Rui Xue, Zitong Wang, Zhe Wang, Qingjie Lv   +6 more
semanticscholar   +1 more source

Two-sample Mendelian randomization analysis evaluates causal associations between inflammatory bowel disease and osteoporosis

Frontiers in Public Health, 2023
Introduction Over the past few years, multiple observational studies have speculated a potential association between inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD), and osteoporosis.
Z. Dai, Weimin Xu, Rui Ding, X. Peng, Xia Shen, Jinglue Song, Peng Du, Zhongchuan Wang, Yun Liu   +8 more
semanticscholar   +1 more source

The role of smoking and alcohol in mediating the effect of gastroesophageal reflux disease on lung cancer: A Mendelian randomization study

Frontiers in Genetics, 2023
Observational studies have suggested a positive association between gastroesophageal reflux disease and lung cancer, but due to the existence of confounders, it remains undetermined whether gastroesophageal reflux disease (GERD) has a causal association ...
Jing Yang, Duorui Nie, Yujing Chen, Zixing Liu, Mengzhao Li, Chun Gong, Qiong Liu   +6 more
doaj   +1 more source

Childhood obesity and hypertension in pregnancy: a two-sample Mendelian randomization analysis

Journal of Hypertension, 2023
Background: The causal relationship between childhood obesity and hypertension in pregnancy remains unclear. To examine the causal association between childhood obesity and hypertension in pregnancy, two-sample Mendelian randomization analysis was ...
Bing Hu, Xin He, Fei Li, Yan-xiang Sun, Jie Sun, Li Feng   +5 more
semanticscholar   +1 more source

A unified framework for joint-tissue transcriptome-wide association and Mendelian Randomization analysis

Nature Genetics, 2020
Here, we present a joint-tissue imputation (JTI) approach and a Mendelian randomization framework for causal inference, MR-JTI. JTI borrows information across transcriptomes of different tissues, leveraging shared genetic regulation, to improve ...
Dan Zhou, Yi Jiang, Xue Zhong, N. Cox, Chunyu Liu, E. Gamazon   +5 more
semanticscholar   +1 more source

Educational attainment, structural brain reserve and Alzheimer’s disease: a Mendelian randomization analysis

medRxiv, 2022
Higher educational attainment is observationally associated with lower risk of Alzheimer's disease. However, the biological mechanisms underpinning this association remain unclear. The protective effect of education on Alzheimer's disease may be mediated
Aida Seyedsalehi, V. Warrier, R. Bethlehem, B. Perry, S. Burgess, G. Murray   +5 more
semanticscholar   +1 more source

Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers: A mendelian randomization analysis

PLoS Medicine, 2022
Background Epidemiological studies have reported conflicting findings on the potential adverse effects of long-term antihypertensive medication use on cancer risk.
J. Yarmolinsky, V. Díez-Obrero, T. Richardson, M. Pigeyre, J. Sjaarda, G. Paré, V. Walker, E. Vincent, V. Y. Tan, M. Obón-Santacana, D. Albanes, J. Hampe, A. Gsur, H. Hampel, R. Pai, M. Jenkins, S. Gallinger, G. Casey, Wei Zheng, C. Amos, George Davey Smith, R. M. Martin, V. Moreno   +22 more
semanticscholar   +1 more source

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

Causal relationship between air pollution, lung function, gastroesophageal reflux disease, and non-alcoholic fatty liver disease: univariate and multivariate Mendelian randomization study

Frontiers in Public Health
BackgroundThe association between air pollution, lung function, gastroesophageal reflux disease, and Non-alcoholic fatty liver disease (NAFLD) remains inconclusive. Previous studies were not convincing due to confounding factors and reverse causality. We
Runmin Cao, Honghe Jiang, Yurun Zhang, Ying Guo, Weibin Zhang   +4 more
doaj   +1 more source

Complex causal association between genetically predicted 731 immunocyte phenotype and osteonecrosis: a bidirectional two-sample Mendelian randomization analysis

International Journal of Surgery
Purpose: Previous studies have explored the role of immune cells on osteonecrosis. This Mendelian randomization (MR) study further assessed 731 immunocyte phenotypes on osteonecrosis, whether a causal relationship exists, and provides some evidence of ...
Wei Li, Jing-Wen Xu, Jin-Lian Chai, Cong-Cong Guo, Guang-Zheng Li, Mei Gao, Xue-zhen Liang   +6 more
semanticscholar   +1 more source