Results 51 to 60 of about 72,268 (331)

Modifiable factors for migraine prophylaxis: A mendelian randomization analysis

Frontiers in Pharmacology, 2023
Objective: To examine the causal effect of potentially modifiable risk factors contributing to migraine pathogenesis.Methods: We performed Mendelian randomization analyses and acquired data from United Kingdom Biobank, FinnGen Biobank, and the MRC IEU OpenGWAS data infrastructure.
Hui Zheng, Yun-Zhou Shi, Jing-Tao Liang, Liang-Liang Lu, Min Chen   +4 more
openaire   +3 more sources

Causal relationship between air pollution, lung function, gastroesophageal reflux disease, and non-alcoholic fatty liver disease: univariate and multivariate Mendelian randomization study

Frontiers in Public Health
BackgroundThe association between air pollution, lung function, gastroesophageal reflux disease, and Non-alcoholic fatty liver disease (NAFLD) remains inconclusive. Previous studies were not convincing due to confounding factors and reverse causality. We
Runmin Cao, Honghe Jiang, Yurun Zhang, Ying Guo, Weibin Zhang   +4 more
doaj   +1 more source

Risk of Esophageal Adenocarcinoma Decreases With Height, Based on Consortium Analysis and Confirmed by Mendelian Randomization [PDF]

, 2014
Background & Aims Risks for some cancers increase with height. We investigated the relationship between height and risk of esophageal adenocarcinoma (EAC) and its precursor, Barrett's esophagus (BE).
Aaron P. Thrift, Alan G. Casson, Albanes, Anderson, Anna H. Wu, Baum, Brian J. Reid, Chow, Cook, Cook, Cook, Davey Smith, Davey Smith, Davey Smith, Davey Smith, David C. Whiteman, David M. Levine, Douglas A. Corley, Engeland, Geoffrey Liu, Green, Greenland, Harvey A. Risch, Hoyo, Hwang, Jacobson, Kabat, Kabat, Kubo, Lagergren, Lagergren, Laura J. Hardie, Lawlor, Leoncini, Leslie Bernstein, Levine, Liao, Lynn Onstad, Marilie D. Gammon, Nicholas J. Shaheen, Nigel C. Bird, O'Doherty, Palmer, Rubenstein, Staiger, Stein, Thomas L. Vaughan, Thrift, Thrift, Thrift, Thrift, Walter, Weimin Ye, Whiteman, Wong–Ho Chow, Yvonne Romero   +55 more
core   +2 more sources

Theoretical impact of insecticide-impregnated school uniforms on dengue incidence in Thai children. [PDF]

, 2013
BACKGROUND: Children carry the main burden of morbidity and mortality caused by dengue. Children spend a considerable amount of their day at school; hence strategies that reduce human-mosquito contact to protect against the day-biting habits of Aedes ...
Amaku, Marcos, Coutinho, Francisco Antonio Bezerra, Kittayapong, Pattamaporn, Massad, Eduardo, Wilder-Smith, Annelies   +4 more
core   +2 more sources

‘Mendelian randomization’ equals instrumental variable analysis with genetic instruments [PDF]

Statistics in Medicine, 2008
AbstractInterest in instrumental variable (IV) analyses using genetic instruments has been growing over the past 4 years. The background, strength and weaknesses of this approach, which in the epidemiology literature has been referred to as ‘Mendelian randomization’, has been recently reviewed by Lawlor et al. (Statist. Med. 2007. DOI: 10.1002/sim.3034)
George L, Wehby, Robert L, Ohsfeldt, Jeffrey C, Murray   +2 more
openaire   +2 more sources

Glucosamine supplementation contributes to reducing the risk of type 2 diabetes: Evidence from Mendelian randomization combined with a meta-analysis

Journal of International Medical Research
Objective Observational studies on glucosamine supplementation and type 2 diabetes risk have shown inconsistent results, necessitating the use of Mendelian randomization to clarify the true causal relationship.
Shuai Zhou, Peiwen Zhou, Tianshi Yang, Junzhuo Si, Wenyan An, Yanfang Jiang   +5 more
doaj   +1 more source

Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. [PDF]

, 2017
Results from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. We evaluated the causal relationship between plasma lipids and DR using a Mendelian randomization approach.
Asian Genetic Epidemiology Network Consortium, Burdon, Kathryn P, Chen, Ching J, Chen, Yii-Der Ida, Cheng, Ching-Yu, Chong, Yong He, Christiansen, Mark W, Cotch, Mary Frances, Craig, Jamie E, Fan, Qiao, Gan, Alfred, Gudnason, Vilmundur, Guo, Xiuqing, Hai, Yang, Hancock, Heather, Hanis, Craig L, Huang, Yu-Chuen, Hung, Yi-Jen, Ipp, Eli, Jensen, Richard A, Jia, Yucheng, Kaidonis, Georgia, Kim, Jihye, Klein, Barbara EK, Klein, Ronald, Kuo, Jane, Lee, Wen-Jane, Li, Xiaohui, Liao, Wen-Ling, Liew, Gerald, Mitchell, Paul, Penman, Alan, Pollack, Samuela, Price, Alkes, Psaty, Bruce M, Rotter, Jerome I, Sandow, Kevin, Smith, Albert V, Sobrin, Lucia, Stanwyck, Lynn K, Tan, Gavin, Tsai, Fuu-Jen, Wang, Jie Jin, Wong, Tien Yin   +43 more
core   +1 more source

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

Associations of Sleep and Shift Work with Osteoarthritis Risk

Arthritis Care &Research, Accepted Article.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships between circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000‐person cohort, we evaluated associations between sleep duration, sleeplessness/insomnia, and ...
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Mendelian randomization study of B-type natriuretic peptide and type 2 diabetes: evidence of causal association from population studies [PDF]

, 2011
<p>Background: Genetic and epidemiological evidence suggests an inverse association between B-type natriuretic peptide (BNP) levels in blood and risk of type 2 diabetes (T2D), but the prospective association of BNP with T2D is uncertain, and it is ...
A Meirhaeghe, AB Ropero, AG Tabak, Aline Meirhaeghe, BF Voight, C Newton-Cheh, C Sengenes, Claudia Langenberg, DC Thomas, DE Lanfear, DJ Halsall, E McFadden, H Choquet, Inês Barroso, JA Taylor, K Miyashita, Kay-Tee Khaw, KT Khaw, LR Potter, M Halbirk, N Chainani-Wu, N Day, Naveed Sattar, NC Onland-Moret, Nicholas J. Wareham, NM De Silva, Paul Welsh, R van Kimmenade, Rachel Mary Freathy, RH Ritchie, RJ Loos, Robert Luben, Roman Pfister, S Soriano, SF Mohammed, Stephen Sharp, T Lauritzen, TJ Wang, TJ Wang, TJ Wang, V Didelez, V Salomaa, Veikko Salomaa, WS Huang, Y Takeishi   +44 more
core   +8 more sources