Results 61 to 70 of about 1,141,533 (358)

Comprehensive mendelian randomization analysis of plasma proteomics to identify new therapeutic targets for the treatment of coronary heart disease and myocardial infarction

Journal of Translational Medicine
Background Ischemic heart disease is one of the leading causes of mortality worldwide, and thus calls for development of more effective therapeutic strategies.
Ziyi Sun, Zhangjun Yun, Jian-Shui Lin, Xiaoning Sun, Qingqing Wang, Jinlong Duan, Cheng Li, Xiaoxiao Zhang, Siyu Xu, Zeqi Wang, Xingjiang Xiong, Kuiwu Yao   +11 more
semanticscholar   +1 more source

Mendelian randomization analysis of 37 clinical factors and coronary artery disease in East Asian and European populations

Genome Medicine, 2022
Coronary artery disease (CAD) remains the leading cause of mortality worldwide despite enormous efforts devoted to its prevention and treatment. While many genetic loci have been identified to associate with CAD, the intermediate causal risk factors and ...
Kai Wang, Xian Shi, Ziwei Zhu, Xingjie Hao, Liangkai Chen, Shanshan Cheng, R. Foo, Chaolong Wang   +7 more
semanticscholar   +1 more source

Adding Mendelian randomization to a meta-analysis—a burgeoning opportunity [PDF]

Tumor Biology, 2015
Current literature is teeming with tens of thousands of meta-analyses, but only a small fraction made seminal contributions to enriching our understanding of the mechanisms of carcinogenesis, possibly due to chance, bias, confounding, or reverse causality.
Wenquan Niu, Mingliang Gu
openaire   +2 more sources

Glucosamine supplementation contributes to reducing the risk of type 2 diabetes: Evidence from Mendelian randomization combined with a meta-analysis

Journal of International Medical Research
Objective Observational studies on glucosamine supplementation and type 2 diabetes risk have shown inconsistent results, necessitating the use of Mendelian randomization to clarify the true causal relationship.
Shuai Zhou, Peiwen Zhou, Tianshi Yang, Junzhuo Si, Wenyan An, Yanfang Jiang   +5 more
doaj   +1 more source

Alcohol consumption, DNA methylation and colorectal cancer risk: Results from pooled cohort studies and Mendelian randomization analysis

International Journal of Cancer, 2022
Alcohol consumption is thought to be one of the modifiable risk factors for colorectal cancer (CRC). However, the causality and mechanisms by which alcohol exerts its carcinogenic effect are unclear.
Xuan Zhou, Lijuan Wang, Jia Xiao, Jing Sun, Lili Yu, Han Zhang, Xiangrui Meng, S. Yuan, M. Timofeeva, P. Law, R. Houlston, K. Ding, M. Dunlop, E. Theodoratou, Xue Li   +14 more
semanticscholar   +1 more source

Advanced Multipurpose Spectroscopic Nanobio‐Device for Concurrent Lab‐on‐a‐Chip Label‐Free Separation and Detection of Extracellular Vesicles as Key‐Biomarkers for Point‐of‐Care Cardiovascular Disease Diagnostics

Advanced Healthcare Materials, EarlyView.
AIMSPec‐LoC is a novel lab‐on‐a‐chip platform integrating size‐based extracellular vesicle (EVs) separation with label‐free Raman spectroscopy and AI‐powered classification via SKiNET. This high‐throughput, portable system enables real‐time, multiplexed molecular fingerprinting of EVs from biofluids, offering transformative potential for early, non ...
Emma Buchan, Jonathan James Stanley Rickard, Mark Robert Thomas, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

Genetic Epidemiology, 2016
Developments in genome‐wide association studies and the increasing availability of summary genetic association data have made application of Mendelian randomization relatively straightforward.
J. Bowden, G. Davey Smith, P. Haycock, S. Burgess   +3 more
semanticscholar   +1 more source

Psoriasis and cardiovascular disease risk in European and East Asian populations: evidence from meta-analysis and Mendelian randomization analysis

BMC Medicine, 2022
Background Psoriasis has been linked to cardiovascular disease (CVD), including coronary artery disease (CAD), myocardial infarction (MI), and heart failure (HF).
Liming Zhang, Yuxiang Wang, L. Qiu, Jian Wu   +3 more
semanticscholar   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Circulating insulin-like growth factors and risks of overall, aggressive and early-onset prostate cancer: a collaborative analysis of 20 prospective studies and Mendelian randomization analysis

International Journal of Epidemiology, 2022
Background Previous studies had limited power to assess the associations of circulating insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) with clinically relevant prostate cancer as a primary endpoint, and the association of ...
E. Watts, A. Perez-Cornago, G. Fensom, K. Smith-Byrne, Urwah Noor, Colm D Andrews, M. Gunter, M. Holmes, R. M. Martin, K. Tsilidis, D. Albanes, A. Barricarte, B. Bueno-de-Mesquita, B. Cohn, M. Deschasaux-Tanguy, N. Dimou, L. Ferrucci, L. Flicker, N. Freedman, G. Giles, E. Giovannucci, C. Haiman, G. Hankey, J. Holly, Jiaqi Huang, Wen-Yi Huang, L. Hurwitz, R. Kaaks, T. Kubo, L. Marchand, R. MacInnis, Satu, E. Metter, K. Mikami, L. Mucci, A. Olsen, K. Ozasa, D. Palli, K. Penney, E. Platz, M. Pollak, M. Roobol, C. Schaefer, J. Schenk, Pa¨r Stattin, A. Tamakoshi, Elin Thysell, C. J. Tsai, M. Touvier, Stephen K Van, Den Eeden, E. Weiderpass, S. Weinstein, L. Wilkens, B. Yeap, C. B. C. P. ‡. N. E. A. The PRACTICAL Consortium, T. Key, R. Travis, Rosalind A. Eeles, Z. Kote-Jarai, F. Schumacher, S. Benlloch, Ali Amin, A. Olama, Kenneth R. Muir, Sonja I. Berndt, David V Conti, F. Wiklund, S. Chanock, Ying Wang, C. Tangen, J. Batra, Judith A. Clements, N. Pashayan, J. Schleutker, A. Wolk, C. Maier, Jeri Kim, Esther M. John, Manuel R Teixeira, S. Neuhausen, K. Ruyck, A. Razack, Lisa F. Newcomb, D. Lessel, R. Kaneva, N. Usmani, F. Claessens, Paul A. Townsend, J. Castelao, F. Menegaux, K. Khaw, L. Cannon-Albright, H. Pandha, Stephen N Thi-bodeau, David J. Hunter, P. Kraft, William J Blot, E. Riboli   +98 more
semanticscholar   +1 more source