Results 81 to 90 of about 72,268 (331)

DNA methylation and body mass index:investigating identified methylation sites at HIF3A in a causal framework [PDF]

, 2016
Multiple differentially methylated sites and regions associated with adiposity have now been identified in large-scale cross-sectional studies. We tested for replication of associations between previously identified CpG sites at HIF3A and adiposity in ∼1,
Fraser, Abigail, Gaunt, Tom R, Lawlor, Debbie A, Lyttleton, Oliver, McArdle, Wendy L, Relton, Caroline L, Richmond, Rebecca C, Ring, Susan M, Sharp, Gemma C, Smith, George Davey, Ward, Mary E   +10 more
core   +2 more sources

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Mendelian randomization analyses explore the relationship between cathepsins and lung cancer

Communications Biology, 2023
Lung cancer, a major contributor to cancer-related fatalities worldwide, involves a complex pathogenesis. Cathepsins, lysosomal cysteine proteases, play roles in various physiological and pathological processes, including tumorigenesis.
Jialin Li, Mingbo Tang, Xinliang Gao, Suyan Tian, Wei Liu   +4 more
doaj   +1 more source

Moderate alcohol use and cardiovascular disease from mendelian randomization [PDF]

, 2013
Background Observational studies show moderate alcohol use negatively associated with ischemic heart disease (IHD) and cardiovascular disease (CVD). However, healthier attributes among moderate users compared to never users may confound the apparent ...
Au Yeung, SLR, Cheng, KK, Cowling, BJ, Jiang, C, Lam, TH, Leung, GM, Liu, B, Schooling, CM, Zhang, W   +8 more
core   +1 more source

Associations Between Sleep Traits and Colorectal Cancer: A Mendelian Randomization Analysis [PDF]

, 2023
Xiangyue Meng, Enshuo Fan, Dan Lv, Yongjing Yang, Shixin Liu   +4 more
openalex   +1 more source

Multi‐View Biomedical Foundation Models for Molecule‐Target and Property Prediction

Advanced Science, EarlyView.
Molecular foundation models can provide accurate predictions for a large set of downstream tasks. We develop MMELON, an approach that integrates pre‐trained graph, image, and text foundation models and validate our multi‐view model on over 120 tasks, including GPCR binding.
Parthasarathy Suryanarayanan, Yunguang Qiu, Shreyans Sethi, Diwakar Mahajan, Hongyang Li, Yuxin Yang, Elif Eyigoz, Aldo Guzmán‐Sáenz, Daniel E. Platt, Timothy H. Rumbell, Kenney Ng, Sanjoy Dey, Myson Burch, Bum Chul Kwon, Pablo Meyer, Feixiong Cheng, Jianying Hu, Joseph A. Morrone   +17 more
wiley   +1 more source

Body mass index and psychiatric disorders:a Mendelian randomization study [PDF]

, 2016
Obesity is a highly prevalent risk factor for cardiometabolic diseases. Observational studies suggest that obesity is associated with psychiatric traits, but causal inference from such studies has several limitations.
Bowden, Jack, Davey Smith, George, Hartwig, Fernando Pires, Horta, Bernardo Lessa, Loret de Mola, Christian, Tovo-Rodrigues, Luciana   +5 more
core   +2 more sources

Study on molecular mechanisms related to hepatic fibrosis by Mendelian randomization combined with transcriptome analysis [PDF]

, 2023
LIANGJIANG HUANG, GUOCHU HUANG, Meng Wang, Dewen Mao, Minggang Wang, Jinghui Zheng, RONGZHEN ZHANG, Fuli Long, Yao Fan, Chun Yao   +9 more
openalex   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Power and sample size calculations for Mendelian randomization studies using one genetic instrument [PDF]

, 2013
postprin
Cowling, BJ, Freeman, G, Schooling, CM
core   +1 more source