Results 101 to 110 of about 10,401 (200)

Longitudinal stability of asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study [PDF]

, 2016
BACKGROUND: Asthma is a biologically heterogeneous disease and development of novel therapeutics requires understanding of pathophysiologic phenotypes. There is uncertainty regarding the stability of clinical characteristics and biomarkers in asthma over
C. Porsbjerg, D. Singh, E. S. Barnathan, F. Baribaud, J. M. FitzGerald, J. N. Kline, M. J. Loza, M. Laviolette, null null, P. Berger, P. Chanez, P. E. Silkoff, P. O. Girodet, S. Kelsen, S. Khatri, V. Backer, V. S. Susulic   +16 more
core   +1 more source

Current Insights Into Individualized Diagnosis and Treatment of Allergic Rhinitis Based on Phenotype and Endotype

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 1, Page 124-135, February 2026.
ABSTRACT Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa characterized by allergen sensitization and the involvement of multiple inflammatory mediators. Currently, the treatment of AR mainly includes symptomatic relief, anti‐inflammatory therapy, and nerve desensitization. However, these treatments have limitations in fully
Yue Gu, Long‐Lan Shu, Tao Lu, Da‐Yu Guan, Bo‐Wen Zheng, Pan‐Hui Xiong, Yang Shen, Yu‐Cheng Yang   +7 more
wiley   +1 more source

Ratio of plasma IL-13/TNF- ∝ and CXCL10/CCL17 predicts mepolizumab and omalizumab response in asthma better than eosinophil count or immunoglobulin E level

Scientific Reports
To date, most studies to identify biomarkers associated with response to the anti-interleukin 5 agent, mepolizumab, and to the anti-immunoglobulin E agent, omalizumab have focused on clinically available biomarkers, such as the peripheral blood ...
Ayobami Akenroye, Tanawin Nopsopon, Jonathan J. Hacker, Tanya M. Laidlaw   +3 more
doaj   +1 more source

Unidad de Asma Difícil: investigación sobre factores etiológicos de agravamiento [PDF]

, 2019
El asma de difícil control engloba a todos aquellos pacientes con asma cuya enfermedad se caracteriza por ser agresiva y estar mal controlada, a pesar de seguir un tratamiento adecuado y ajustado a su clínica.
Santa Olaya García, Ana
core  

Peak nasal inspiratory flow assessment of polyp size and response from SYNAPSE

Journal of Allergy and Clinical Immunology: Global
Background: In the phase III SYNAPSE study, mepolizumab plus standard of care reduced total endoscopic nasal polyp score (NPS) versus that with placebo in patients with chronic rhinosinusitis with nasal polyps.
Amber U. Luong, MD, PhD, Joshua M. Levy, MD, MPH, MSc, Ludger Klimek, MD, PhD, Richard J. Harvey, MD, Jared Silver, MD, PhD, Steven G. Smith, PhD, Abby Fuller, MSc, Robert Chan, MD, Peter W. Hellings, MD, PhD   +8 more
doaj   +1 more source

Budget Impact Analysis of Mepolizumab for Eligible Patients in the Setting of a Severe Asthma Clinic Within Dubai Health Authority (DHA)

ClinicoEconomics and Outcomes Research, 2022
Bassam Mahboub,1 Ahmed Mohy,2 Islam El-Amir,2 Tamara Lukić,3 Raef Gouhar,4 Saeed Noibi5 1Pulmonary Medicine Department, Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates; 2Medical Affairs Department, GSK, Jeddah, Kingdom of ...
Mahboub B, Mohy A, El-Amir I, Lukić T, Gouhar R, Noibi S   +5 more
doaj  

Effectiveness and Safety of Omalizumab for Chronic Spontaneous Urticaria During Pregnancy: A Systematic Review

International Journal of Dermatology, EarlyView.
Ioannis‐Alexios Koumprentziotis, Michael Makris, Alexander Stratigos, Stamatios Gregoriou   +3 more
wiley   +1 more source

Real-World Experience on the Use of Mepolizumab from the Severe Asthma Registry of the German Asthma Net (MepoGAN-Study)

Journal of Asthma and Allergy, 2023
Stephanie Korn,1 Katrin Milger,2 Dirk Skowasch,3 Christian Schulz,4 Cordula Mohrlang,5 Martin Wernitz,5 Thomas Paulsson,6 Michael Hennig,5 Roland Buhl7 1IKF Pneumologie Mainz, Mainz and Thoraxklinik Heidelberg, Heidelberg, Germany; 2Department of ...
Korn S, Milger K, Skowasch D, Schulz C, Mohrlang C, Wernitz M, Paulsson T, Hennig M, Buhl R   +8 more
doaj  

Poliangeitis amb Granulomatosis eosinofílica i asma al·lèrgica; dues monedes amb una mateixa cara? [PDF]

, 2013
La síndrome de Churg-Strauss o Poliangeitis amb Granulomatosis eosinofílica (EGPA), clàssicament s'ha vinculat a un substrat asmàtic d'origen al·lèrgic. No obstant, l'evidència en aquest sentit és equívoca.
Bosch Gil, Josep Àngel, Ramentol Sintas, Marc, Solans Laqué, Roser, Universitat Autònoma de Barcelona. Departament de Medicina, Universitat Autònoma de Barcelona. Facultat de Medicina   +4 more
core  

Real-World Reductions in Oral Corticosteroid Use in the USA Following Mepolizumab Therapy for Severe Asthma

Journal of Asthma and Allergy, 2020
Jared Silver,1 Michael Bogart,1 Elizabeth Packnett,2 Juan Wu,2 Donna McMorrow,2 Beth Hahn1 1US Medical Affairs, GSK, Research Triangle Park, NC, USA; 2Life Sciences, IBM Watson Health, Bethesda, MD, USACorrespondence: Beth Hahn Email beth.a.hahn@gsk ...
Silver J, Bogart M, Packnett E, Wu J, McMorrow D, Hahn B   +5 more
doaj